Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Redivo, Elijane de Fatima
Data de Publicação: 2020
Outros Autores: Alecrim, Maria das Graças Costa, Andrade, Anny Beatriz Costa Antony de, Martinez-Espinosa, Flor Ernestina, Castilho, Marcia da Costa, Brock, Mariana, Magno, Evela da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45451
Resumo: This work was supported by Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT–HVD); Foundation for Research Support of the State of Amazonas (FAPEAM); the Ministry of Health of Brazil (PPSUS; and DECIT-TED 51/2019); and Leônidas and Maria Deane Institute (ILMD/ Fiocruz Amazônia) in partnership with the Nacional Council for Scientific and Technological Development (CNPq)
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spelling Redivo, Elijane de FatimaAlecrim, Maria das Graças CostaAndrade, Anny Beatriz Costa Antony deMartinez-Espinosa, Flor ErnestinaCastilho, Marcia da CostaBrock, MarianaMagno, Evela da Silva2020-12-28T18:32:32Z2020-12-28T18:32:32Z2020REDIVO, Elijane de Fátima et al. Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon. Viruses, Basel, v. 12, n. 12, p. 1-16, 28 Nov. 2020.1999-4915https://www.arca.fiocruz.br/handle/icict/4545110.3390/v12121362This work was supported by Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT–HVD); Foundation for Research Support of the State of Amazonas (FAPEAM); the Ministry of Health of Brazil (PPSUS; and DECIT-TED 51/2019); and Leônidas and Maria Deane Institute (ILMD/ Fiocruz Amazônia) in partnership with the Nacional Council for Scientific and Technological Development (CNPq)Universidade do Estado Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Universidade do Estado Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Programa de Pós-Graduação em Condições de Vida e Situações de Saúde na Amazônia - PPGVIDA. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Programa de Pós-Graduação em Condições de Vida e Situações de Saúde na Amazônia - PPGVIDA. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Virologia. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Departamento de Medicina. Escola de Ciências da Saúde. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Epidemiologia e Saúde Pública. Manaus, AM, Brasil.The epidemic transmission of Zika virus (ZIKV) in Brazil has been identified as a cause of microcephaly and other neurological malformations in the babies of ZIKV-infected women. The frequency of adverse outcomes of Zika virus infection (ZIKVi) in pregnancy di ers depending on the characteristics of exposure to infection, the time of recruitment of research participants, and the outcomes to be observed. This study provides a descriptive analysis—from the onset of symptoms to delivery—of a cohort registered as having maternal ZIKVi in pregnancy, from November 2015 to December 2016. Suspected cases were registered at a referral center for infectious and tropical diseases in Manaus, in the Amazonian region of Brazil. Of 834 women notified, 762 women with confirmed pregnancies were enrolled. Reverse-transcriptase polymerase chain reaction (RT-PCR) confirmed ZIKVi in 42.3% of the cohort. In 35.2% of the cohort, ZIKV was the sole infection identified. Severe adverse pregnancy outcomes (miscarriage, stillbirth, or microcephaly) were observed in both RT-PCR ZIKV-positive (5.0%) and ZIKV-negative (1.8%) cases (RR 3.1; 95% IC 1.4–7.3; p < 0.05), especially during the first trimester of pregnancy (RR 6.2, 95% IC 2.3–16.5; p < 0.001). Although other infectious rash diseases were observed in the pregnant women in the study, having confirmed maternal ZIKVi was the most important risk factor for serious adverse pregnancy events.engMDPIZika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleZIKV infectionMicrocephalyExanthematic disease in pregnancyTORCH Syndromeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/45451/1/license.txt43cf57123dace9a28c9f6b2c996fa81bMD51ORIGINALArticle REDIVO; MENEZES; CASTILHO; BROCK; MAGNO; FERNANDES, ANDRADE; ALECRIM; MARTINEZ-ESPINOSA.pdfArticle REDIVO; MENEZES; CASTILHO; BROCK; MAGNO; FERNANDES, ANDRADE; ALECRIM; MARTINEZ-ESPINOSA.pdfapplication/pdf950872https://www.arca.fiocruz.br/bitstream/icict/45451/2/Article%20REDIVO%3b%20MENEZES%3b%20CASTILHO%3b%20BROCK%3b%20MAGNO%3b%20FERNANDES%2c%20ANDRADE%3b%20ALECRIM%3b%20MARTINEZ-ESPINOSA.pdf0d96d311ee1aee149aa6f0df542ecf2dMD52TEXTArticle REDIVO; MENEZES; CASTILHO; BROCK; MAGNO; FERNANDES, ANDRADE; ALECRIM; MARTINEZ-ESPINOSA.pdf.txtArticle REDIVO; MENEZES; CASTILHO; BROCK; MAGNO; FERNANDES, ANDRADE; ALECRIM; MARTINEZ-ESPINOSA.pdf.txtExtracted texttext/plain46335https://www.arca.fiocruz.br/bitstream/icict/45451/3/Article%20REDIVO%3b%20MENEZES%3b%20CASTILHO%3b%20BROCK%3b%20MAGNO%3b%20FERNANDES%2c%20ANDRADE%3b%20ALECRIM%3b%20MARTINEZ-ESPINOSA.pdf.txt7f3cd17f3e318890f0eeab4fc0a337b4MD53icict/454512020-12-29 12:26:35.108oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-12-29T15:26:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
title Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
spellingShingle Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
Redivo, Elijane de Fatima
ZIKV infection
Microcephaly
Exanthematic disease in pregnancy
TORCH Syndrome
title_short Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
title_full Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
title_fullStr Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
title_full_unstemmed Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
title_sort Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
author Redivo, Elijane de Fatima
author_facet Redivo, Elijane de Fatima
Alecrim, Maria das Graças Costa
Andrade, Anny Beatriz Costa Antony de
Martinez-Espinosa, Flor Ernestina
Castilho, Marcia da Costa
Brock, Mariana
Magno, Evela da Silva
author_role author
author2 Alecrim, Maria das Graças Costa
Andrade, Anny Beatriz Costa Antony de
Martinez-Espinosa, Flor Ernestina
Castilho, Marcia da Costa
Brock, Mariana
Magno, Evela da Silva
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Redivo, Elijane de Fatima
Alecrim, Maria das Graças Costa
Andrade, Anny Beatriz Costa Antony de
Martinez-Espinosa, Flor Ernestina
Castilho, Marcia da Costa
Brock, Mariana
Magno, Evela da Silva
dc.subject.en.pt_BR.fl_str_mv ZIKV infection
Microcephaly
Exanthematic disease in pregnancy
TORCH Syndrome
topic ZIKV infection
Microcephaly
Exanthematic disease in pregnancy
TORCH Syndrome
description This work was supported by Tropical Medicine Foundation Dr Heitor Vieira Dourado (FMT–HVD); Foundation for Research Support of the State of Amazonas (FAPEAM); the Ministry of Health of Brazil (PPSUS; and DECIT-TED 51/2019); and Leônidas and Maria Deane Institute (ILMD/ Fiocruz Amazônia) in partnership with the Nacional Council for Scientific and Technological Development (CNPq)
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-12-28T18:32:32Z
dc.date.available.fl_str_mv 2020-12-28T18:32:32Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv REDIVO, Elijane de Fátima et al. Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon. Viruses, Basel, v. 12, n. 12, p. 1-16, 28 Nov. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45451
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/v12121362
identifier_str_mv REDIVO, Elijane de Fátima et al. Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon. Viruses, Basel, v. 12, n. 12, p. 1-16, 28 Nov. 2020.
1999-4915
10.3390/v12121362
url https://www.arca.fiocruz.br/handle/icict/45451
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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