Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis
| Autor(a) principal: | |
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| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30396 |
Resumo: | 2020-01-01 |
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Resende, Lucilene AparecidaRoatt, Bruno MendesSoares, Rodrigo Dian de Oliveira AguiarViana, Kelvinson FernandesMendonça, Ludmila ZanandreisLanna, Mariana FerreiraLemos, Denise SilveiraOliveira, Rodrigo Corrêa deMartins Filho, Olindo AssisFujiwara, Ricardo ToshioCarneiro, Cláudia MartinsReis, Alexandre BarbosaGiunchetti, Rodolfo Cordeiro2018-12-05T15:11:17Z2018-12-05T15:11:17Z2013RESENDE, Lucilene Aparecida et al. Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis. Veterinary Parasitology, v. 198, n. 3-4, p. 371-381, 2013.0304-4017https://www.arca.fiocruz.br/handle/icict/3039610.1016/j.vetpar.2013.09.011engElsevier Scientific Pub. CoLeishmaniose visceral caninacitocinasImunoproteçãoLeishmania chagasivacinaCanine visceral leishmaniasisCytokinesImmunoprotectionLeishmania chagasiVaccineCytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.In the studies presented here, dogs were vaccinated against Leishmania (Leishmania) chagasi challenge infection using a preparation of Leishmania braziliensis promastigote proteins and saponin as adjuvant (LBSap). Vaccination with LBSap induced a prominent type 1 immune response that was characterized by increased levels of interleukin (IL-) 12 and interferon gamma (IFN-γ) production by peripheral blood mononuclear cells (PBMC) upon stimulation with soluble vaccine antigen. Importantly, results showed that this type of responsiveness was sustained after challenge infection; at day 90 and 885 after L. chagasi challenge infection, PBMCs from LBSap vaccinated dogs produced more IL-12, IFN-γ and concomitant nitric oxide (NO) when stimulated with Leishmania antigens as compared to PBMCs from respective control groups (saponin, LB- treated, or non-treated control dogs). Moreover, transforming growth factor (TGF)-β decreased in the supernatant of SLcA-stimulated PBMCs in the LBSap group at 90 days. Bone marrow parasitological analysis revealed decreased frequency of parasitism in the presence of vaccine antigen. It is concluded that vaccination of dogs with LBSap vaccine induced a long-lasting type 1 immune response against L. chagasi challenge infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30396/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCytokine and nitric oxide.pdfCytokine and nitric oxide.pdfapplication/pdf6481466https://www.arca.fiocruz.br/bitstream/icict/30396/2/Cytokine%20and%20nitric%20oxide.pdf748ffb94e03b837b0da42c592ff97db5MD52TEXTCytokine and nitric oxide.pdf.txtCytokine and nitric oxide.pdf.txtExtracted texttext/plain3241https://www.arca.fiocruz.br/bitstream/icict/30396/3/Cytokine%20and%20nitric%20oxide.pdf.txt85b52ccb8fdc2590cd63814ca42c7c5cMD53icict/303962021-03-24 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| dc.title.pt_BR.fl_str_mv |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| title |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| spellingShingle |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis Resende, Lucilene Aparecida Leishmaniose visceral canina citocinas Imunoproteção Leishmania chagasi vacina Canine visceral leishmaniasis Cytokines Immunoprotection Leishmania chagasi Vaccine |
| title_short |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| title_full |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| title_fullStr |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| title_full_unstemmed |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| title_sort |
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis |
| author |
Resende, Lucilene Aparecida |
| author_facet |
Resende, Lucilene Aparecida Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Viana, Kelvinson Fernandes Mendonça, Ludmila Zanandreis Lanna, Mariana Ferreira Lemos, Denise Silveira Oliveira, Rodrigo Corrêa de Martins Filho, Olindo Assis Fujiwara, Ricardo Toshio Carneiro, Cláudia Martins Reis, Alexandre Barbosa Giunchetti, Rodolfo Cordeiro |
| author_role |
author |
| author2 |
Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Viana, Kelvinson Fernandes Mendonça, Ludmila Zanandreis Lanna, Mariana Ferreira Lemos, Denise Silveira Oliveira, Rodrigo Corrêa de Martins Filho, Olindo Assis Fujiwara, Ricardo Toshio Carneiro, Cláudia Martins Reis, Alexandre Barbosa Giunchetti, Rodolfo Cordeiro |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Resende, Lucilene Aparecida Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Viana, Kelvinson Fernandes Mendonça, Ludmila Zanandreis Lanna, Mariana Ferreira Lemos, Denise Silveira Oliveira, Rodrigo Corrêa de Martins Filho, Olindo Assis Fujiwara, Ricardo Toshio Carneiro, Cláudia Martins Reis, Alexandre Barbosa Giunchetti, Rodolfo Cordeiro |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose visceral canina citocinas Imunoproteção Leishmania chagasi vacina |
| topic |
Leishmaniose visceral canina citocinas Imunoproteção Leishmania chagasi vacina Canine visceral leishmaniasis Cytokines Immunoprotection Leishmania chagasi Vaccine |
| dc.subject.en.pt_BR.fl_str_mv |
Canine visceral leishmaniasis Cytokines Immunoprotection Leishmania chagasi Vaccine |
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2020-01-01 |
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2013 |
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2013 |
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2018-12-05T15:11:17Z |
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2018-12-05T15:11:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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RESENDE, Lucilene Aparecida et al. Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis. Veterinary Parasitology, v. 198, n. 3-4, p. 371-381, 2013. |
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https://www.arca.fiocruz.br/handle/icict/30396 |
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0304-4017 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.vetpar.2013.09.011 |
| identifier_str_mv |
RESENDE, Lucilene Aparecida et al. Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis. Veterinary Parasitology, v. 198, n. 3-4, p. 371-381, 2013. 0304-4017 10.1016/j.vetpar.2013.09.011 |
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https://www.arca.fiocruz.br/handle/icict/30396 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier Scientific Pub. Co |
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Elsevier Scientific Pub. Co |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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