2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23623 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Meira, Cássio SantanaGuimarães, Elisalva TeixeiraMoreira, Diogo Rodrigo de MagalhãesLeite, Ana Cristina LimaPereira, Valeria Rego AlvesMelo, C. M. LNeves, Juliana Kelle de Andrade LemoineSoares, Milena Botelho Pereira2017-12-12T16:42:16Z2017-12-12T16:42:16Z2012MEIRA, C. S. et al. 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012https://www.arca.fiocruz.br/handle/icict/23623engSociedade Brasileira de Medicina TropicalTrypanosoma cruziDoença de ChagasQuimioterapiaMacrófagosInfecçãoAnimaisCamundongosTrypanosoma cruziChagas diseaseChemotherapyMacrophagesInfectionAnimalsMice2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, BrazilFederal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, BrasilChagas disease, caused by the flagellate protozoan Trypanosoma cruzi, affects about 18 million people in the Americas. Current chemotherapy of Chagas disease is based on benznidazole, which is toxic and has limited efficacy. Therefore, new chemotherapeutic agents need to be developed. In this work, we describe the identification of eight Trypanosoma cruzi inhibitors through a combination of thiazoles and hydrazones chemistry.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23623/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALChagas112 Meira CS SBMT 2012.pdfChagas112 Meira CS SBMT 2012.pdfapplication/pdf86590https://www.arca.fiocruz.br/bitstream/icict/23623/2/Chagas112%20Meira%20CS%20SBMT%202012.pdfd6796b66b09c793aed8da620281a47ecMD52TEXTChagas112 Meira CS SBMT 2012.pdf.txtChagas112 Meira CS SBMT 2012.pdf.txtExtracted texttext/plain2924https://www.arca.fiocruz.br/bitstream/icict/23623/3/Chagas112%20Meira%20CS%20SBMT%202012.pdf.txtfdc6f7cc8ff86e3b06b7e171a1e7401aMD53icict/236232019-06-26 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| dc.title.pt_BR.fl_str_mv |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| title |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| spellingShingle |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages Meira, Cássio Santana Trypanosoma cruzi Doença de Chagas Quimioterapia Macrófagos Infecção Animais Camundongos Trypanosoma cruzi Chagas disease Chemotherapy Macrophages Infection Animals Mice |
| title_short |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| title_full |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| title_fullStr |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| title_full_unstemmed |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| title_sort |
2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages |
| author |
Meira, Cássio Santana |
| author_facet |
Meira, Cássio Santana Guimarães, Elisalva Teixeira Moreira, Diogo Rodrigo de Magalhães Leite, Ana Cristina Lima Pereira, Valeria Rego Alves Melo, C. M. L Neves, Juliana Kelle de Andrade Lemoine Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Guimarães, Elisalva Teixeira Moreira, Diogo Rodrigo de Magalhães Leite, Ana Cristina Lima Pereira, Valeria Rego Alves Melo, C. M. L Neves, Juliana Kelle de Andrade Lemoine Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Meira, Cássio Santana Guimarães, Elisalva Teixeira Moreira, Diogo Rodrigo de Magalhães Leite, Ana Cristina Lima Pereira, Valeria Rego Alves Melo, C. M. L Neves, Juliana Kelle de Andrade Lemoine Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas Quimioterapia Macrófagos Infecção Animais Camundongos |
| topic |
Trypanosoma cruzi Doença de Chagas Quimioterapia Macrófagos Infecção Animais Camundongos Trypanosoma cruzi Chagas disease Chemotherapy Macrophages Infection Animals Mice |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas disease Chemotherapy Macrophages Infection Animals Mice |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2012 |
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2012 |
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2017-12-12T16:42:16Z |
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2017-12-12T16:42:16Z |
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info:eu-repo/semantics/publishedVersion |
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MEIRA, C. S. et al. 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012 |
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https://www.arca.fiocruz.br/handle/icict/23623 |
| identifier_str_mv |
MEIRA, C. S. et al. 2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012 |
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Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical |
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