Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11209 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Rodrigues, Ana Carolina B. CBomfim, Larissa MendesNeves, Sara PMenezes, Leociley Rocha AlencarDias, Rosane BorgesSoares, Milena Botelho PereiraPrata, Ana Paula NRocha, Clarissa Araújo GurgelCosta, Emmanoel VilaçaBezerra, Daniel Pereira2015-07-10T13:39:36Z2015-07-10T13:39:36Z2015RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 20150032-0943https://www.arca.fiocruz.br/handle/icict/1120910.1055/s-0035-1563130engGeorg Thieme VerlagAntitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Sergipe. Department of Chemistry. São Cristovão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFederal University of Sergipe. Department of Biology. São Cristovão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Propedêutica. Salvador, BA, BrasilFederal University of Amazonas. Department of Chemistry. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilDuguetia gardneriana, popularly known in the Brazilian northeast as “jaquinha”, is a species belonging to the family Annonaceae. The aim of this work was to assess the chemical composition and antitumor properties of the essential oil from the leaves of D. gardneriana in experimental models. The chemical composition of the essential oil was analyzed via gas chromatography-flame ionization detector and gas chromatography-mass spectrometry. In vitro cytotoxic activity was determined in cultured tumor cells, and in vivo antitumor activity was assessed in B16-F10-bearing mice. The identified compounds were β-bisabolene (80.99%), elemicin (8.04%), germacrene D (4.15%), and cyperene (2.82%). The essential oil exhibited a cytotoxic effect, with IC50 values of 16.89, 19.16, 13.08, and 19.33 μg/mL being obtained for B16-F10, HepG2, HL-60, and K562 cell lines, respectively. On the other hand, β-bisabolene was inactive in all of the tested tumor cell lines (showing IC50 values greater than 25 μg/ mL). The in vivo analysis revealed tumor growth inhibition rates of 5.37–37.52% at doses of 40 and 80mg/kg/day, respectively. Herein, the essential oil from the leaves of D. gardneriana presented β-bisabolene as the major constituent and showed cytotoxic and antitumor potential.Duguetia GardnerianaAnnonaceaeEssential oilCytotoxicAntitumorinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11209/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALRodrigues ACBC Antitumor....pdfRodrigues ACBC Antitumor....pdfapplication/pdf142853https://www.arca.fiocruz.br/bitstream/icict/11209/2/Rodrigues%20ACBC%20Antitumor....pdfdb7ecf9b40d453b0b76d913201aa845dMD52TEXTRodrigues ACBC Antitumor....pdf.txtRodrigues ACBC Antitumor....pdf.txtExtracted texttext/plain32744https://www.arca.fiocruz.br/bitstream/icict/11209/3/Rodrigues%20ACBC%20Antitumor....pdf.txta7ad84edf7080ebe5eedf1bdb6e3b185MD53icict/112092023-03-15 14:33:25.007oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| title |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| spellingShingle |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Rodrigues, Ana Carolina B. C Duguetia Gardneriana Annonaceae Essential oil Cytotoxic Antitumor |
| title_short |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| title_full |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| title_fullStr |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| title_full_unstemmed |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| title_sort |
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. |
| author |
Rodrigues, Ana Carolina B. C |
| author_facet |
Rodrigues, Ana Carolina B. C Bomfim, Larissa Mendes Neves, Sara P Menezes, Leociley Rocha Alencar Dias, Rosane Borges Soares, Milena Botelho Pereira Prata, Ana Paula N Rocha, Clarissa Araújo Gurgel Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author_role |
author |
| author2 |
Bomfim, Larissa Mendes Neves, Sara P Menezes, Leociley Rocha Alencar Dias, Rosane Borges Soares, Milena Botelho Pereira Prata, Ana Paula N Rocha, Clarissa Araújo Gurgel Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rodrigues, Ana Carolina B. C Bomfim, Larissa Mendes Neves, Sara P Menezes, Leociley Rocha Alencar Dias, Rosane Borges Soares, Milena Botelho Pereira Prata, Ana Paula N Rocha, Clarissa Araújo Gurgel Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| dc.subject.en.pt_BR.fl_str_mv |
Duguetia Gardneriana Annonaceae Essential oil Cytotoxic Antitumor |
| topic |
Duguetia Gardneriana Annonaceae Essential oil Cytotoxic Antitumor |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2015 |
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2015-07-10T13:39:36Z |
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2015-07-10T13:39:36Z |
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2015 |
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RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 2015 |
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https://www.arca.fiocruz.br/handle/icict/11209 |
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0032-0943 |
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10.1055/s-0035-1563130 |
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RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 2015 0032-0943 10.1055/s-0035-1563130 |
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Georg Thieme Verlag |
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Georg Thieme Verlag |
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