Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58449 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Juiz de Fora. Instituto de Ciências da Vida. Departamento de Medicina. Governador Valadares, MG, Brazil. |
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Nunes, Gabriela SilveiraDurso, Danielle FernandesOliveira Junior, Luiz Roberto Alves deCunha, Eloisa Helena MedeirosMaioli, Tatiani UceliVieira, Angélica ThomazSpeziali, ElaineOliveira, Rodrigo CorrêaMartins Filho, Olindo AssisCarvalho, Andrea TeixeiraFranceschi, ClaudioRampelli, SimoneTurroni, SilviaBrigidi, PatriziaFaria, Ana Maria Caetano2023-05-16T19:17:19Z2023-05-16T19:17:19Z2020SILVEIRA-NUNES, Gabriela et al. Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population. Front Pharmacol., v. 11, 258, 2020. doi: 10.3389/fphar.2020.00258.1663-9812https://www.arca.fiocruz.br/handle/icict/5844910.3389/fphar.2020.00258engFrontiers MediaHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Juiz de Fora. Instituto de Ciências da Vida. Departamento de Medicina. Governador Valadares, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.Núcleo da Saúde. Universidade Vale do Rio Doce, Governador Valadares, MG, Brazil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Nutrição. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.IRCCS Istituto delle Scienze Neurologiche di Bologna. Bologna, Italy/Department of Applied Mathematics. Institute of Information Technology, Mathematics and Mechanics. Lobachevsky State University of Nizhny Novgorod. Nizhny Novgorod, Russia.Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy.Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy.Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.Hypertension is a major global health challenge, as it represents the main risk factor for stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by high and sustained levels of blood pressure, likely resulting from a complex interplay of endogenous and environmental factors. The gut microbiota has been strongly supposed to be involved but its role in hypertension is still poorly understood. In an attempt to fill this gap, here we characterized the microbial composition of fecal samples from 48 hypertensive and 32 normotensive Brazilian individuals by next-generation sequencing of the 16S rRNA gene. In addition, the cytokine production of peripheral blood samples was investigated to build an immunological profile of these individuals. We identified a dysbiosis of the intestinal microbiota in hypertensive subjects, featured by reduced biodiversity and distinct bacterial signatures compared with the normotensive counterpart. Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of Lactobacillus and Akkermansia while decreased relative abundances of well-known butyrate-producing commensals, including Roseburia and Faecalibacterium within the Lachnospiraceae and Ruminococcaceae families. We also observed an inflamed immune profile in hypertensive individuals with an increase in TNF/IFN-gamma ratio, and in TNF and IL-6 production when compared to normotensive ones. Our work provides the first evidence of association of hypertension with altered gut microbiota and inflammation in a Brazilian population. While lending support to the existence of potential microbial signatures of hypertension, likely to be robust to age and geography, our findings point to largely neglected bacteria as potential contributors to intestinal homeostasis loss and emphasize the high vulnerability of hypertensive individuals to inflammation-related disorders.dysbiosisgut microbiotahypertensionimmune profileinflammationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population - 4457.pdfHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population - 4457.pdfapplication/pdf1107570https://www.arca.fiocruz.br/bitstream/icict/58449/2/Hypertension%20Is%20Associated%20With%20Intestinal%20Microbiota%20Dysbiosis%20and%20Inflammation%20in%20a%20Brazilian%20Population%20-%204457.pdf3607d4e1ddc0b7d9d934e61437e75b73MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58449/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584492023-05-16 16:17:19.956oai:www.arca.fiocruz.br:icict/58449Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-16T19:17:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| spellingShingle |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population Nunes, Gabriela Silveira dysbiosis gut microbiota hypertension immune profile inflammation |
| title_short |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_full |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_fullStr |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_full_unstemmed |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_sort |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| author |
Nunes, Gabriela Silveira |
| author_facet |
Nunes, Gabriela Silveira Durso, Danielle Fernandes Oliveira Junior, Luiz Roberto Alves de Cunha, Eloisa Helena Medeiros Maioli, Tatiani Uceli Vieira, Angélica Thomaz Speziali, Elaine Oliveira, Rodrigo Corrêa Martins Filho, Olindo Assis Carvalho, Andrea Teixeira Franceschi, Claudio Rampelli, Simone Turroni, Silvia Brigidi, Patrizia Faria, Ana Maria Caetano |
| author_role |
author |
| author2 |
Durso, Danielle Fernandes Oliveira Junior, Luiz Roberto Alves de Cunha, Eloisa Helena Medeiros Maioli, Tatiani Uceli Vieira, Angélica Thomaz Speziali, Elaine Oliveira, Rodrigo Corrêa Martins Filho, Olindo Assis Carvalho, Andrea Teixeira Franceschi, Claudio Rampelli, Simone Turroni, Silvia Brigidi, Patrizia Faria, Ana Maria Caetano |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nunes, Gabriela Silveira Durso, Danielle Fernandes Oliveira Junior, Luiz Roberto Alves de Cunha, Eloisa Helena Medeiros Maioli, Tatiani Uceli Vieira, Angélica Thomaz Speziali, Elaine Oliveira, Rodrigo Corrêa Martins Filho, Olindo Assis Carvalho, Andrea Teixeira Franceschi, Claudio Rampelli, Simone Turroni, Silvia Brigidi, Patrizia Faria, Ana Maria Caetano |
| dc.subject.en.en_US.fl_str_mv |
dysbiosis gut microbiota hypertension immune profile inflammation |
| topic |
dysbiosis gut microbiota hypertension immune profile inflammation |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Juiz de Fora. Instituto de Ciências da Vida. Departamento de Medicina. Governador Valadares, MG, Brazil. |
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2020 |
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2020 |
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2023-05-16T19:17:19Z |
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2023-05-16T19:17:19Z |
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info:eu-repo/semantics/article |
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SILVEIRA-NUNES, Gabriela et al. Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population. Front Pharmacol., v. 11, 258, 2020. doi: 10.3389/fphar.2020.00258. |
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10.3389/fphar.2020.00258 |
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SILVEIRA-NUNES, Gabriela et al. Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population. Front Pharmacol., v. 11, 258, 2020. doi: 10.3389/fphar.2020.00258. 1663-9812 10.3389/fphar.2020.00258 |
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