Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3389/fphar.2020.00258 http://hdl.handle.net/1843/66223 https://orcid.org/0000-0002-7538-3208 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-03-20T20:12:57Z2024-03-20T20:12:57Z2020-03-111125814https://doi.org/10.3389/fphar.2020.002581663-9812http://hdl.handle.net/1843/66223https://orcid.org/0000-0002-7538-3208CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorHypertension is a major global health challenge, as it represents the main risk factor for stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by high and sustained levels of blood pressure, likely resulting from a complex interplay of endogenous and environmental factors. The gut microbiota has been strongly supposed to be involved but its role in hypertension is still poorly understood. In an attempt to fill this gap, here we characterized the microbial composition of fecal samples from 48 hypertensive and 32 normotensive Brazilian individuals by next-generation sequencing of the 16S rRNA gene. In addition, the cytokine production of peripheral blood samples was investigated to build an immunological profile of these individuals. We identified a dysbiosis of the intestinal microbiota in hypertensive subjects, featured by reduced biodiversity and distinct bacterial signatures compared with the normotensive counterpart. Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of Lactobacillus and Akkermansia while decreased relative abundances of well-known butyrate-producing commensals, including Roseburia and Faecalibacterium within the Lachnospiraceae and Ruminococcaceae families. We also observed an inflamed immune profile in hypertensive individuals with an increase in TNF/IFN-γ ratio, and in TNF and IL-6 production when compared to normotensive ones. Our work provides the first evidence of association of hypertension with altered gut microbiota and inflammation in a Brazilian population. While lending support to the existence of potential microbial signatures of hypertension, likely to be robust to age and geography, our findings point to largely neglected bacteria as potential contributors to intestinal homeostasis loss and emphasize the high vulnerability of hypertensive individuals to inflammation-related disorders.engUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE NUTRIÇÃOENFERMAGEM - ESCOLA DE ENFERMAGEMICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAFrontiers in PharmacologyMicrobiotaInflamaçãoHipertensãoImunidadeGut microbiotaDysbiosisHypertensionInflammationImmune profileHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00258/fullGabriela Silveira-NunesAndrea Teixeira-CarvalhoClaudio FranceschiSimone RampelliSilvia TurroniPatrizia BrigidiAna Maria Caetano FariaDanielle Fernandes DursoLuiz Roberto Alves de Oliveira Jr.Eloisa Helena Medeiros CunhaTatiani Uceli MaioliAngelica Thomaz VieiraElaine SpezialiRodrigo Corrêa-oliveiraOlindo Assis Martins-filhoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/66223/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population.pdfHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population.pdfapplication/pdf3621789https://repositorio.ufmg.br/bitstream/1843/66223/2/Hypertension%20Is%20Associated%20With%20Intestinal%20Microbiota%20Dysbiosis%20and%20Inflammation%20in%20a%20Brazilian%20Population.pdf72d7b2da5eddbc5c5d74a57aba9b5635MD521843/662232024-03-20 17:12:58.32oai:repositorio.ufmg.br:1843/66223TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-20T20:12:58Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| spellingShingle |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population Gabriela Silveira-Nunes Gut microbiota Dysbiosis Hypertension Inflammation Immune profile Microbiota Inflamação Hipertensão Imunidade |
| title_short |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_full |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_fullStr |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_full_unstemmed |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| title_sort |
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population |
| author |
Gabriela Silveira-Nunes |
| author_facet |
Gabriela Silveira-Nunes Andrea Teixeira-Carvalho Claudio Franceschi Simone Rampelli Silvia Turroni Patrizia Brigidi Ana Maria Caetano Faria Danielle Fernandes Durso Luiz Roberto Alves de Oliveira Jr. Eloisa Helena Medeiros Cunha Tatiani Uceli Maioli Angelica Thomaz Vieira Elaine Speziali Rodrigo Corrêa-oliveira Olindo Assis Martins-filho |
| author_role |
author |
| author2 |
Andrea Teixeira-Carvalho Claudio Franceschi Simone Rampelli Silvia Turroni Patrizia Brigidi Ana Maria Caetano Faria Danielle Fernandes Durso Luiz Roberto Alves de Oliveira Jr. Eloisa Helena Medeiros Cunha Tatiani Uceli Maioli Angelica Thomaz Vieira Elaine Speziali Rodrigo Corrêa-oliveira Olindo Assis Martins-filho |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gabriela Silveira-Nunes Andrea Teixeira-Carvalho Claudio Franceschi Simone Rampelli Silvia Turroni Patrizia Brigidi Ana Maria Caetano Faria Danielle Fernandes Durso Luiz Roberto Alves de Oliveira Jr. Eloisa Helena Medeiros Cunha Tatiani Uceli Maioli Angelica Thomaz Vieira Elaine Speziali Rodrigo Corrêa-oliveira Olindo Assis Martins-filho |
| dc.subject.por.fl_str_mv |
Gut microbiota Dysbiosis Hypertension Inflammation Immune profile |
| topic |
Gut microbiota Dysbiosis Hypertension Inflammation Immune profile Microbiota Inflamação Hipertensão Imunidade |
| dc.subject.other.pt_BR.fl_str_mv |
Microbiota Inflamação Hipertensão Imunidade |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020-03-11 |
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2024-03-20T20:12:57Z |
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2024-03-20T20:12:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/66223 |
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https://doi.org/10.3389/fphar.2020.00258 |
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1663-9812 |
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https://orcid.org/0000-0002-7538-3208 |
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https://doi.org/10.3389/fphar.2020.00258 http://hdl.handle.net/1843/66223 https://orcid.org/0000-0002-7538-3208 |
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1663-9812 |
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eng |
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eng |
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Frontiers in Pharmacology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ENF - DEPARTAMENTO DE NUTRIÇÃO ENFERMAGEM - ESCOLA DE ENFERMAGEM ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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