Cardiac Regeneration using Growth Factors: Advances and Challenges
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16553 |
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Rebouças, Juliana de SouzaMagalhães, Nereide Stela SantosFormiga, Fabio Rocha2016-12-15T17:43:44Z2016-12-15T17:43:44Z2016REBOUÇAS, J. S.; MAGALHÃES, N. S. S.; FORMIGA, F. R. Cardiac Regeneration using Growth Factors: Advances and Challenges. Arquivos Brasileiros de Cardiologia, v. 107, n. 3, p. 271-275, 2016.0066-782Xhttps://www.arca.fiocruz.br/handle/icict/1655310.5935/abc.20160097CNPqUniversidade Federal de Pernambuco. UFPE. Laboratório de Imunopatologia Keizo-Asami. Recife, PE, BrasilUniversidade Federal de Pernambuco. UFPE. Laboratório de Imunopatologia Keizo-Asami. Recife, PE, BrasilUniversidade de Pernambuco. UPE. Recife, PE, Brasil / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMyocardial infarction is the most significant manifestation of ischemic heart disease and is associated with high morbidity and mortality. Novel strategies targeting at regenerating the injured myocardium have been investigated, including gene therapy, cell therapy, and the use of growth factors. Growth factor therapy has aroused interest in cardiovascular medicine because of the regeneration mechanisms induced by these biomolecules, including angiogenesis, extracellular matrix remodeling, cardiomyocyte proliferation, stem-cell recruitment, and others. Together, these mechanisms promote myocardial repair and improvement of the cardiac function. This review aims to address the strategic role of growth factor therapy in cardiac regeneration, considering its innovative and multifactorial character in myocardial repair after ischemic injury. Different issues will be discussed, with emphasis on the regeneration mechanisms as a potential therapeutic resource mediated by growth factors, and the challenges to make these proteins therapeutically viable in the field of cardiology and regenerative medicine. Resumo O infarto do miocárdio representa a manifestação mais significativa da cardiopatia isquêmica e está associado a elevada morbimortalidade. Novas estratégias vêm sendo investigadas com o intuito de regenerar o miocárdio lesionado, incluindo a terapia gênica, a terapia celular e a utilização de fatores de crescimento. A terapia com fatores de crescimento despertou interesse em medicina cardiovascular, devido aos mecanismos de regeneração induzidos por essas biomoléculas, incluindo angiogênese, remodelamento da matriz extracelular, proliferação de cardiomiócitos e recrutamento de células-tronco, dentre outros. Em conjunto, tais mecanismos promovem a reparação do miocárdio e a melhora da função cardíaca. Esta revisão pretende abordar o papel estratégico da terapia, com fatores de crescimento, para a regeneração cardíaca, considerando seu caráter inovador e multifatorial sobre o reparo do miocárdio após dano isquêmico. Diferentes questões serão discutidas, destacando-se os mecanismos de regeneração como recurso terapêutico potencial mediado por fatores de crescimento e os desafios para tornar essas proteínas terapeuticamente viáveis no âmbito da cardiologia e da medicina regenerativa.engSociedade Brasileira de CardiologiaInfarto do miocárdioIsquemia do miocárdioRemodelação VascularPeptídeos e Proteínas de Sinalização IntercelularTerapia baseada em células e tecidosMyocardial InfarctionMyocardial IschemiaVascular RemodelingIntercellular Signaling Peptides and ProteinsCell-and Tissue Based TherapyCardiac Regeneration using Growth Factors: Advances and Challengesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
title |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
spellingShingle |
Cardiac Regeneration using Growth Factors: Advances and Challenges Rebouças, Juliana de Souza Infarto do miocárdio Isquemia do miocárdio Remodelação Vascular Peptídeos e Proteínas de Sinalização Intercelular Terapia baseada em células e tecidos Myocardial Infarction Myocardial Ischemia Vascular Remodeling Intercellular Signaling Peptides and Proteins Cell-and Tissue Based Therapy |
title_short |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
title_full |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
title_fullStr |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
title_full_unstemmed |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
title_sort |
Cardiac Regeneration using Growth Factors: Advances and Challenges |
author |
Rebouças, Juliana de Souza |
author_facet |
Rebouças, Juliana de Souza Magalhães, Nereide Stela Santos Formiga, Fabio Rocha |
author_role |
author |
author2 |
Magalhães, Nereide Stela Santos Formiga, Fabio Rocha |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Rebouças, Juliana de Souza Magalhães, Nereide Stela Santos Formiga, Fabio Rocha |
dc.subject.other.pt_BR.fl_str_mv |
Infarto do miocárdio Isquemia do miocárdio Remodelação Vascular Peptídeos e Proteínas de Sinalização Intercelular Terapia baseada em células e tecidos |
topic |
Infarto do miocárdio Isquemia do miocárdio Remodelação Vascular Peptídeos e Proteínas de Sinalização Intercelular Terapia baseada em células e tecidos Myocardial Infarction Myocardial Ischemia Vascular Remodeling Intercellular Signaling Peptides and Proteins Cell-and Tissue Based Therapy |
dc.subject.en.pt_BR.fl_str_mv |
Myocardial Infarction Myocardial Ischemia Vascular Remodeling Intercellular Signaling Peptides and Proteins Cell-and Tissue Based Therapy |
description |
CNPq |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-12-15T17:43:44Z |
dc.date.available.fl_str_mv |
2016-12-15T17:43:44Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
REBOUÇAS, J. S.; MAGALHÃES, N. S. S.; FORMIGA, F. R. Cardiac Regeneration using Growth Factors: Advances and Challenges. Arquivos Brasileiros de Cardiologia, v. 107, n. 3, p. 271-275, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/16553 |
dc.identifier.issn.pt_BR.fl_str_mv |
0066-782X |
dc.identifier.doi.none.fl_str_mv |
10.5935/abc.20160097 |
identifier_str_mv |
REBOUÇAS, J. S.; MAGALHÃES, N. S. S.; FORMIGA, F. R. Cardiac Regeneration using Growth Factors: Advances and Challenges. Arquivos Brasileiros de Cardiologia, v. 107, n. 3, p. 271-275, 2016. 0066-782X 10.5935/abc.20160097 |
url |
https://www.arca.fiocruz.br/handle/icict/16553 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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