Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9727 |
Resumo: | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, United States of America |
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Andrade, Bruno de BezerrilSingh, AmritNarendran, GopalanSchechter, Melissa E.Nayak, KaustuvSubramanian, SudhaAnbalagan, SelvarajJensen, Stig M. R.Porter, Brian O.Antonelli, Lis Ribeiro do ValleWilkinson, Katalin A.Wilkinson, Robert J.Meintjes, GraemePlas, Helen van derFollmann, DeanBarber, Daniel L.Swaminathan, SoumyaSher, AlanSereti, Irini2015-03-17T17:17:24Z2015-03-17T17:17:24Z2014ANDRADE, Bruno de Bezerril et al. Associated Immune Reconstitution Inflammatory Syndrome. PLoS Pathog, v. 10, n. 10, p. e1004433, 20141553-7366https://www.arca.fiocruz.br/handle/icict/972710.1371/journal.ppat.1004433engPublic Library of ScienceMycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of AmericaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of AmericaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of AmericaLaboratório de Imunopatologia, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, BrazilUniversity of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South AfricaUniversity of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South Africa/Imperial College London. Department of Medicine. London, United Kingdom/MRC National Institute for Medical Research. London, United KingdomUniversity of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South Africa/Imperial College London. Department of Medicine. London, United KingdomUniversity of Cape Town. Institute of Infectious Disease and Molecular Medicine, and Department of Medicine. Clinical Infectious Diseases Research Initiative. Cape Town, South AfricaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Biostatistics Research Branch. Bethesda, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases. Bethesda, MD, United States of AmericaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases.Laboratory of Immunoregulation. Clinical and Molecular Retrovirology Section. Bethesda, MD, United States of AmericaParadoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response occurring in a subset of TB-HIV co-infected patients initiating anti-retroviral therapy (ART). Here, we examined monocyte activation by prospectively quantitating pro-inflammatory plasma markers and monocyte subsets in TB-HIV co-infected patients from a South Indian cohort at baseline and following ART initiation at the time of IRIS, or at equivalent time points in non-IRIS controls. Pro-inflammatory biomarkers of innate and myeloid cell activation were increased in plasma of IRIS patients pre-ART and at the time of IRIS; this association was confirmed in a second cohort in South Africa. Increased expression of these markers correlated with elevated antigen load as measured by higher sputum culture grade and shorter duration of anti-TB therapy. Phenotypic analysis revealed the frequency of CD14++CD16− monocytes was an independent predictor of TB-IRIS, and was closely associated with plasma levels of CRP, TNF, IL-6 and tissue factor during IRIS. In addition, production of inflammatory cytokines by monocytes was higher in IRIS patients compared to controls pre-ART. These data point to a major role of mycobacterial antigen load and myeloid cell hyperactivation in the pathogenesis of TB-IRIS, and implicate monocytes and monocyte-derived cytokines as potential targets for TB-IRIS prevention or treatment.diseasestuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9727/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINAL2014_157.pdf2014_157.pdfapplication/pdf8039547https://www.arca.fiocruz.br/bitstream/icict/9727/2/2014_157.pdf61886898f8eac99f8b159f84a0aed9a8MD52TEXT2014_157.pdf.txt2014_157.pdf.txtExtracted texttext/plain73328https://www.arca.fiocruz.br/bitstream/icict/9727/3/2014_157.pdf.txt9b2e458b7f0cc658c80fbe17a002d83dMD53icict/97272021-10-21 12:36:12.399oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-10-21T15:36:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| title |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| spellingShingle |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Andrade, Bruno de Bezerril diseases tuberculosis |
| title_short |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| title_full |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| title_fullStr |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| title_full_unstemmed |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| title_sort |
Mycobacterial Antigen Driven Activation of CD14++CD162 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome |
| author |
Andrade, Bruno de Bezerril |
| author_facet |
Andrade, Bruno de Bezerril Singh, Amrit Narendran, Gopalan Schechter, Melissa E. Nayak, Kaustuv Subramanian, Sudha Anbalagan, Selvaraj Jensen, Stig M. R. Porter, Brian O. Antonelli, Lis Ribeiro do Valle Wilkinson, Katalin A. Wilkinson, Robert J. Meintjes, Graeme Plas, Helen van der Follmann, Dean Barber, Daniel L. Swaminathan, Soumya Sher, Alan Sereti, Irini |
| author_role |
author |
| author2 |
Singh, Amrit Narendran, Gopalan Schechter, Melissa E. Nayak, Kaustuv Subramanian, Sudha Anbalagan, Selvaraj Jensen, Stig M. R. Porter, Brian O. Antonelli, Lis Ribeiro do Valle Wilkinson, Katalin A. Wilkinson, Robert J. Meintjes, Graeme Plas, Helen van der Follmann, Dean Barber, Daniel L. Swaminathan, Soumya Sher, Alan Sereti, Irini |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Bruno de Bezerril Singh, Amrit Narendran, Gopalan Schechter, Melissa E. Nayak, Kaustuv Subramanian, Sudha Anbalagan, Selvaraj Jensen, Stig M. R. Porter, Brian O. Antonelli, Lis Ribeiro do Valle Wilkinson, Katalin A. Wilkinson, Robert J. Meintjes, Graeme Plas, Helen van der Follmann, Dean Barber, Daniel L. Swaminathan, Soumya Sher, Alan Sereti, Irini |
| dc.subject.en.pt_BR.fl_str_mv |
diseases tuberculosis |
| topic |
diseases tuberculosis |
| description |
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, United States of America |
| publishDate |
2014 |
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2014 |
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2015-03-17T17:17:24Z |
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2015-03-17T17:17:24Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ANDRADE, Bruno de Bezerril et al. Associated Immune Reconstitution Inflammatory Syndrome. PLoS Pathog, v. 10, n. 10, p. e1004433, 2014 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/9727 |
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1553-7366 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.ppat.1004433 |
| identifier_str_mv |
ANDRADE, Bruno de Bezerril et al. Associated Immune Reconstitution Inflammatory Syndrome. PLoS Pathog, v. 10, n. 10, p. e1004433, 2014 1553-7366 10.1371/journal.ppat.1004433 |
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