Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes

Detalhes bibliográficos
Autor(a) principal: Freitas, Carla Rangel Leite
Data de Publicação: 1999
Outros Autores: Barbosa Junior, Aryon de Almeida, Fernandes, André L. M, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5648
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Freitas, Carla Rangel LeiteBarbosa Junior, Aryon de AlmeidaFernandes, André L. MAndrade, Zilton de Araújo2012-10-04T21:35:19Z2012-10-04T21:35:19Z1999FREITAS, C.R. et al. Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes. Memórias do Instituto Oswaldo Cruz, v. 94, n. 6, p. 815-22, nov.-dec. 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/5648engPathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, BrasilHistological, ultrastructural, morphometric and immunohistochemical data obtained from the study of spleens removed by splenectomy from 34 patients with advanced hepatosplenic schistosomiasis revealed that the main alterations were congestive dilatation of the venous sinuses and diffuse thickening of the splenic cords. Splenic cord thickening was due to an increase of its matrix components, especially type IV collagen and laminin, with the conspicuous absence of interstitial collagens, either of type I or type III. Deposition of interstitial collagens (types I and III) occurred in scattered, small focal areas of the red pulp, but in the outside of the walls of the venous sinuses, in lymph follicles, marginal zone, in the vicinity of fibrous trabeculae and in sidero-sclerotic nodules. However, fibrosis was not a prominent change in schistosomal splenomegaly and thus the designation "fibro-congestive splenomegaly" seems inadequate. Lymph follicles exhibited variable degrees of atrophy, hyperplasia and fibrous replacement, sometimes all of them seen in different follicles of the same spleen and even in the same examined section. Changes in white pulp did not seem to greatly contribute to increasing spleen size and weight, when compared to the much more significant red pulp enlargement.SplenomegalyHepatosplenic schistosomiaisExtra-cellular matrixHistopathologyMorphometryMatriz Extracelular/patologiaHepatopatias Parasitárias/patologiaEsquistossomose/patologiaEsplenopatias/patologiaEsplenopatias/parasitologiaAdolescenteAdultoFemininoHumanosMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFreitas CR Pathology of the spleen....pdfFreitas CR Pathology of the spleen....pdfapplication/pdf856459https://www.arca.fiocruz.br/bitstream/icict/5648/1/Freitas%20CR%20Pathology%20of%20the%20spleen....pdf944918e05927a54548fe854701738245MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5648/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTFreitas CR Pathology of the spleen....pdf.txtFreitas CR Pathology of the spleen....pdf.txtExtracted texttext/plain21742https://www.arca.fiocruz.br/bitstream/icict/5648/5/Freitas%20CR%20Pathology%20of%20the%20spleen....pdf.txta5e94187448589627907ddbbfc5d951fMD55THUMBNAILFreitas CR Pathology of the spleen....pdf.jpgFreitas CR Pathology of the spleen....pdf.jpgGenerated Thumbnailimage/jpeg2325https://www.arca.fiocruz.br/bitstream/icict/5648/4/Freitas%20CR%20Pathology%20of%20the%20spleen....pdf.jpg2b921b538cf24b65b685a8b590c1195dMD54icict/56482023-03-15 14:33:22.306oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
title Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
spellingShingle Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
Freitas, Carla Rangel Leite
Splenomegaly
Hepatosplenic schistosomiais
Extra-cellular matrix
Histopathology
Morphometry
Matriz Extracelular/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose/patologia
Esplenopatias/patologia
Esplenopatias/parasitologia
Adolescente
Adulto
Feminino
Humanos
Masculino
Meia-Idade
title_short Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
title_full Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
title_fullStr Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
title_full_unstemmed Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
title_sort Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
author Freitas, Carla Rangel Leite
author_facet Freitas, Carla Rangel Leite
Barbosa Junior, Aryon de Almeida
Fernandes, André L. M
Andrade, Zilton de Araújo
author_role author
author2 Barbosa Junior, Aryon de Almeida
Fernandes, André L. M
Andrade, Zilton de Araújo
author2_role author
author
author
dc.contributor.author.fl_str_mv Freitas, Carla Rangel Leite
Barbosa Junior, Aryon de Almeida
Fernandes, André L. M
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Splenomegaly
Hepatosplenic schistosomiais
Extra-cellular matrix
Histopathology
Morphometry
topic Splenomegaly
Hepatosplenic schistosomiais
Extra-cellular matrix
Histopathology
Morphometry
Matriz Extracelular/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose/patologia
Esplenopatias/patologia
Esplenopatias/parasitologia
Adolescente
Adulto
Feminino
Humanos
Masculino
Meia-Idade
dc.subject.decs.pt_BR.fl_str_mv Matriz Extracelular/patologia
Hepatopatias Parasitárias/patologia
Esquistossomose/patologia
Esplenopatias/patologia
Esplenopatias/parasitologia
Adolescente
Adulto
Feminino
Humanos
Masculino
Meia-Idade
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2012-10-04T21:35:19Z
dc.date.available.fl_str_mv 2012-10-04T21:35:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, C.R. et al. Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes. Memórias do Instituto Oswaldo Cruz, v. 94, n. 6, p. 815-22, nov.-dec. 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5648
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv FREITAS, C.R. et al. Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes. Memórias do Instituto Oswaldo Cruz, v. 94, n. 6, p. 815-22, nov.-dec. 1999.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5648
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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