Multibacillary leprosy by population groups in Brazil: Lessons from an observational study

Detalhes bibliográficos
Autor(a) principal: Nobre, Mauricio Lisboa
Data de Publicação: 2017
Outros Autores: Illarramendi Rojas, Ximena, Dupnik, Kathryn Margaret, Hacker, Mariana de Andrea, Nery, José Augusto da Costa, Jerônimo, Selma Maria Bezerra, Sarno, Euzenir Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pntd.0005364
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23827
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil / Secretaria Estadual de Saúde. Hospital Giselda Trigueiro. Natal, RN, Brasil / Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil.
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spelling Nobre, Mauricio LisboaIllarramendi Rojas, XimenaDupnik, Kathryn MargaretHacker, Mariana de AndreaNery, José Augusto da CostaJerônimo, Selma Maria BezerraSarno, Euzenir Nunes2017-12-28T14:37:13Z2017-12-28T14:37:13Z2017NOBRE, Mauricio Lisboa et al. Multibacillary leprosy by population groups in Brazil: Lessons from an observational study. PLoS Neglected Tropical Disease, v. 11, n. 2, p. e0005364, 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/2382710.1371/journal.pntd.0005364engPlosHanseníase multibacilarEstudo observacionalMultibacillary leprosy by population groups in Brazil: Lessons from an observational studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil / Secretaria Estadual de Saúde. Hospital Giselda Trigueiro. Natal, RN, Brasil / Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Weill Cornell Medical College. Division of Infectious Diseases and Center for Global Health. New York, NY, United States of America.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil / Universidade Federal do Rio Grande do Norte. Centro de Biociências. Departamento de Bioquímica. Natal, RN, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT). Natal, RN, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Leprosy remains an important public health problem in Brazil where 28,761 new cases were diagnosed in 2015, the second highest number of new cases detected globally. The disease is caused by Mycobacterium leprae, a pathogen spread by patients with multibacillary (MB) leprosy. This study was designed to identify population groups most at risk for MB disease in Brazil, contributing to new ideas for early diagnosis and leprosy control. Methods: A national databank of cases reported in Brazil (2001–2013) was used to evaluate epidemiological characteristics of MB leprosy. Additionally, the databank of a leprosy reference center was used to determine factors associated with higher bacillary loads. Results: A total of 541,090 cases were analyzed. New case detection rates (NCDRs) increased with age, especially for men with MB leprosy, reaching 44.8 new cases/100,000 population in 65–69 year olds. Males and subjects older than 59 years had twice the odds of MB leprosy than females and younger cases (OR = 2.36, CI95% = 2.33–2.38; OR = 1.99, CI95% = 1.96–2.02, respectively). Bacillary load was higher in male and in patients aged 20–39 and 40–59 years compared to females and other age groups. From 2003 to 2013, there was a progressive reduction in annual NCDRs and an increase in the percentage of MB cases and of elderly patients in Brazil. These data suggest reduction of leprosy transmission in the country. Conclusion: Public health policies for leprosy control in endemic areas in Brazil should include activities especially addressed to men and to the elderly in order to further reduce M. leprae transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/23827/1/license.txt425ef259bcb460998407fbfed7c102d0MD51ORIGINALIllarramendi_etal_2017a.pdfIllarramendi_etal_2017a.pdfapplication/pdf1050016https://www.arca.fiocruz.br/bitstream/icict/23827/2/Illarramendi_etal_2017a.pdf2d9a53da1e2d6d67e52d944816eb60d9MD52TEXTIllarramendi_etal_2017a.pdf.txtIllarramendi_etal_2017a.pdf.txtExtracted texttext/plain44363https://www.arca.fiocruz.br/bitstream/icict/23827/3/Illarramendi_etal_2017a.pdf.txt96afb334c6db8ab11e8fbf6a274525d8MD53icict/238272023-09-04 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dc.title.pt_BR.fl_str_mv Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
title Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
spellingShingle Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
Nobre, Mauricio Lisboa
Hanseníase multibacilar
Estudo observacional
title_short Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
title_full Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
title_fullStr Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
title_full_unstemmed Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
title_sort Multibacillary leprosy by population groups in Brazil: Lessons from an observational study
author Nobre, Mauricio Lisboa
author_facet Nobre, Mauricio Lisboa
Illarramendi Rojas, Ximena
Dupnik, Kathryn Margaret
Hacker, Mariana de Andrea
Nery, José Augusto da Costa
Jerônimo, Selma Maria Bezerra
Sarno, Euzenir Nunes
author_role author
author2 Illarramendi Rojas, Ximena
Dupnik, Kathryn Margaret
Hacker, Mariana de Andrea
Nery, José Augusto da Costa
Jerônimo, Selma Maria Bezerra
Sarno, Euzenir Nunes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nobre, Mauricio Lisboa
Illarramendi Rojas, Ximena
Dupnik, Kathryn Margaret
Hacker, Mariana de Andrea
Nery, José Augusto da Costa
Jerônimo, Selma Maria Bezerra
Sarno, Euzenir Nunes
dc.subject.other.pt_BR.fl_str_mv Hanseníase multibacilar
Estudo observacional
topic Hanseníase multibacilar
Estudo observacional
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil / Secretaria Estadual de Saúde. Hospital Giselda Trigueiro. Natal, RN, Brasil / Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-12-28T14:37:13Z
dc.date.available.fl_str_mv 2017-12-28T14:37:13Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NOBRE, Mauricio Lisboa et al. Multibacillary leprosy by population groups in Brazil: Lessons from an observational study. PLoS Neglected Tropical Disease, v. 11, n. 2, p. e0005364, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23827
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005364
identifier_str_mv NOBRE, Mauricio Lisboa et al. Multibacillary leprosy by population groups in Brazil: Lessons from an observational study. PLoS Neglected Tropical Disease, v. 11, n. 2, p. e0005364, 2017.
1935-2727
10.1371/journal.pntd.0005364
url https://www.arca.fiocruz.br/handle/icict/23827
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Plos
publisher.none.fl_str_mv Plos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23827/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/23827/2/Illarramendi_etal_2017a.pdf
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