Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41197 |
Resumo: | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Hungria, Emerith MayraBührer-Sékula, SamiraOliveira, Regiane Morillas deAderaldo, Lúcio CartaxoPontes, Maria Araci de AndradeCruz, RossileneGonçalves, Heitor de SáPenna, Maria Lucia FernandesPenna, Gerson OliveiraStefani, Mariane Martins de Araújo2020-05-12T14:30:34Z2020-05-12T14:30:34Z2017HUNGRI, Emerith Mayra et al. Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR). Plos Neglected Tropical Diseases, [San Francisco], v. 11, n. 2, p. 1-17, feb. 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/4119710.1371/journal.pntd.0005396Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Malcolm Duthie, Greg Ireton, Jeff Guderian, Raodoh Mohamath and Ayesha Misquith (IDRI, USA) e Tsuyoshi Fujiwara (Nara University, Japan) ajudaram no fornecimento de materiais para a pesquisa.FAPEG e CNPqUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Niterói, RJ, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Background: Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil/U-MDT/CT-BR is suitable to evaluate its prognostic value for the development of reactions. Methodology: IgM and IgG antibody responses to PGL-I, LID-1, ND-O-LID were evaluated by ELISA in 452 reaction-free leprosy patients at diagnosis, enrolled and monitored for the development of leprosy reactions during a total person-time of 780,930 person-days, i.e. 2139.5 person-years, with a maximum of 6.66 years follow-up time. Principal findings: Among these patients, 36% (160/452) developed reactions during follow-up: 26% (119/452) RR and 10% (41/452) had ENL. At baseline higher anti-PGL-I, anti-LID-1 and anti-ND-O-LID seropositivity rates were seen in patients who developed ENL and RR compared to reaction-free patients (p<0.0001). Seroreactivity in reactional and reaction-free patients was stratified by bacilloscopic index/BI categories. Among BI negative patients, higher anti-PGL-I levels were seen in RR compared to reaction-free patients (p = 0.014). In patients with 0<BI<3, (36 RR, 36 reaction-free), higher antibody levels to PGL-I (p = 0.014) and to LID-1 (p = 0.035) were seen in RR while difference in anti-ND-O-LID positivity was borderline (p = 0.052). Patients with BI≥3 that developed ENL had higher levels of anti-LID-1 antibodies (p = 0.028) compared to reaction-free patients. Anti-PGL-I serology had a limited predictive value for RR according to receiver operating curve/ROC analyses (area-under-the-curve/AUC = 0.7). Anti LID-1 serology at baseline showed the best performance to predict ENL (AUC 0.85). Conclusions: Overall, detection of anti-PGL-I, anti-LID-1 and anti-ND-O-LID antibodies at diagnosis, showed low sensitivity and specificity for RR prediction, indicating low applicability of serological tests for RR prognosis. On the other hand, anti-LID-1 serology at diagnosis has shown prognostic value for ENL development in BI positive patients.engPublic Library of ScienceAntibodies, BacterialBrazilEnzyme-Linked Immunosorbent AssayImmunoglobulin GImmunoglobulin MLeprosyMycobacterium lepraePredictive Value of TestsPrognosisSensitivity and SpecificitySerologic TestsLeprosyMycobacterium lepraeSerologyDiagnosis of health situationHanseníaseMycobacterium lepraeImunoglobulina GImunoglobulina MTestes SorológicosDiagnóstico da Situação de SaúdeLeprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
title |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
spellingShingle |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) Hungria, Emerith Mayra Antibodies, Bacterial Brazil Enzyme-Linked Immunosorbent Assay Immunoglobulin G Immunoglobulin M Leprosy Mycobacterium leprae Predictive Value of Tests Prognosis Sensitivity and Specificity Serologic Tests Leprosy Mycobacterium leprae Serology Diagnosis of health situation Hanseníase Mycobacterium leprae Imunoglobulina G Imunoglobulina M Testes Sorológicos Diagnóstico da Situação de Saúde |
title_short |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
title_full |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
title_fullStr |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
title_full_unstemmed |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
title_sort |
Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR) |
author |
Hungria, Emerith Mayra |
author_facet |
Hungria, Emerith Mayra Bührer-Sékula, Samira Oliveira, Regiane Morillas de Aderaldo, Lúcio Cartaxo Pontes, Maria Araci de Andrade Cruz, Rossilene Gonçalves, Heitor de Sá Penna, Maria Lucia Fernandes Penna, Gerson Oliveira Stefani, Mariane Martins de Araújo |
author_role |
author |
author2 |
Bührer-Sékula, Samira Oliveira, Regiane Morillas de Aderaldo, Lúcio Cartaxo Pontes, Maria Araci de Andrade Cruz, Rossilene Gonçalves, Heitor de Sá Penna, Maria Lucia Fernandes Penna, Gerson Oliveira Stefani, Mariane Martins de Araújo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hungria, Emerith Mayra Bührer-Sékula, Samira Oliveira, Regiane Morillas de Aderaldo, Lúcio Cartaxo Pontes, Maria Araci de Andrade Cruz, Rossilene Gonçalves, Heitor de Sá Penna, Maria Lucia Fernandes Penna, Gerson Oliveira Stefani, Mariane Martins de Araújo |
dc.subject.mesh.pt_BR.fl_str_mv |
Antibodies, Bacterial Brazil Enzyme-Linked Immunosorbent Assay Immunoglobulin G Immunoglobulin M Leprosy Mycobacterium leprae Predictive Value of Tests Prognosis Sensitivity and Specificity Serologic Tests |
topic |
Antibodies, Bacterial Brazil Enzyme-Linked Immunosorbent Assay Immunoglobulin G Immunoglobulin M Leprosy Mycobacterium leprae Predictive Value of Tests Prognosis Sensitivity and Specificity Serologic Tests Leprosy Mycobacterium leprae Serology Diagnosis of health situation Hanseníase Mycobacterium leprae Imunoglobulina G Imunoglobulina M Testes Sorológicos Diagnóstico da Situação de Saúde |
dc.subject.en.pt_BR.fl_str_mv |
Leprosy Mycobacterium leprae Serology Diagnosis of health situation |
dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Mycobacterium leprae Imunoglobulina G Imunoglobulina M Testes Sorológicos Diagnóstico da Situação de Saúde |
description |
Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-05-12T14:30:34Z |
dc.date.available.fl_str_mv |
2020-05-12T14:30:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
HUNGRI, Emerith Mayra et al. Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR). Plos Neglected Tropical Diseases, [San Francisco], v. 11, n. 2, p. 1-17, feb. 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/41197 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0005396 |
identifier_str_mv |
HUNGRI, Emerith Mayra et al. Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR). Plos Neglected Tropical Diseases, [San Francisco], v. 11, n. 2, p. 1-17, feb. 2017. 1935-2727 10.1371/journal.pntd.0005396 |
url |
https://www.arca.fiocruz.br/handle/icict/41197 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/41197/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/41197/2/ve_Emerith_Hungria_etal.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/3/ve_Emerith_Hungria_etal%201.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/4/ve_Emerith_Hungria_etal%202.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/5/ve_Emerith_Hungria_etal%203.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/6/ve_Emerith_Hungria_etal%204.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/7/ve_Emerith_Hungria_etal%205.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/8/ve_Emerith_Hungria_etal%206.pdf https://www.arca.fiocruz.br/bitstream/icict/41197/9/ve_Emerith_Hungria_etal.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/41197/10/ve_Emerith_Hungria_etal%201.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/41197/11/ve_Emerith_Hungria_etal%202.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/41197/12/ve_Emerith_Hungria_etal%203.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/41197/13/ve_Emerith_Hungria_etal%204.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/41197/14/ve_Emerith_Hungria_etal%205.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/41197/15/ve_Emerith_Hungria_etal%206.pdf.txt |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 1baf94e7224532edee524b91e90f494c b95cb522b72322c861be7aa98d20ed81 19915f12f511737181c14fec063791f6 d29446f8fe095d41995e137dcf5da58c 17b4194d1c6ab9400ac7e8a0b84bdc7a a75255bbefbc24080542e42a24d1bf30 3a00ad0fcc2ce056671a3bd8cc721358 16a4cb914e4ca889f18b8fe3cb653181 f15d62e650ec25b89d95f169ad408019 dac417b6c45b77f1deb582b9db9381a5 7138d520ccbc6e037dd3dfcdcbcec680 68b329da9893e34099c7d8ad5cb9c940 68b329da9893e34099c7d8ad5cb9c940 68b329da9893e34099c7d8ad5cb9c940 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813009058725101568 |