Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)

Detalhes bibliográficos
Autor(a) principal: Hungria, Emerith Mayra
Data de Publicação: 2017
Outros Autores: Bührer-Sékula, Samira, Oliveira, Regiane Morillas de, Aderaldo, Lúcio Cartaxo, Pontes, Maria Araci de Andrade, Cruz, Rossilene, Gonçalves, Heitor de Sá, Penna, Maria Lucia Fernandes, Penna, Gerson Oliveira, Stefani, Mariane Martins de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41197
Resumo: Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
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spelling Hungria, Emerith MayraBührer-Sékula, SamiraOliveira, Regiane Morillas deAderaldo, Lúcio CartaxoPontes, Maria Araci de AndradeCruz, RossileneGonçalves, Heitor de SáPenna, Maria Lucia FernandesPenna, Gerson OliveiraStefani, Mariane Martins de Araújo2020-05-12T14:30:34Z2020-05-12T14:30:34Z2017HUNGRI, Emerith Mayra et al. Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR). Plos Neglected Tropical Diseases, [San Francisco], v. 11, n. 2, p. 1-17, feb. 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/4119710.1371/journal.pntd.0005396Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Malcolm Duthie, Greg Ireton, Jeff Guderian, Raodoh Mohamath and Ayesha Misquith (IDRI, USA) e Tsuyoshi Fujiwara (Nara University, Japan) ajudaram no fornecimento de materiais para a pesquisa.FAPEG e CNPqUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Niterói, RJ, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Background: Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil/U-MDT/CT-BR is suitable to evaluate its prognostic value for the development of reactions. Methodology: IgM and IgG antibody responses to PGL-I, LID-1, ND-O-LID were evaluated by ELISA in 452 reaction-free leprosy patients at diagnosis, enrolled and monitored for the development of leprosy reactions during a total person-time of 780,930 person-days, i.e. 2139.5 person-years, with a maximum of 6.66 years follow-up time. Principal findings: Among these patients, 36% (160/452) developed reactions during follow-up: 26% (119/452) RR and 10% (41/452) had ENL. At baseline higher anti-PGL-I, anti-LID-1 and anti-ND-O-LID seropositivity rates were seen in patients who developed ENL and RR compared to reaction-free patients (p<0.0001). Seroreactivity in reactional and reaction-free patients was stratified by bacilloscopic index/BI categories. Among BI negative patients, higher anti-PGL-I levels were seen in RR compared to reaction-free patients (p = 0.014). In patients with 0<BI<3, (36 RR, 36 reaction-free), higher antibody levels to PGL-I (p = 0.014) and to LID-1 (p = 0.035) were seen in RR while difference in anti-ND-O-LID positivity was borderline (p = 0.052). Patients with BI≥3 that developed ENL had higher levels of anti-LID-1 antibodies (p = 0.028) compared to reaction-free patients. Anti-PGL-I serology had a limited predictive value for RR according to receiver operating curve/ROC analyses (area-under-the-curve/AUC = 0.7). Anti LID-1 serology at baseline showed the best performance to predict ENL (AUC 0.85). Conclusions: Overall, detection of anti-PGL-I, anti-LID-1 and anti-ND-O-LID antibodies at diagnosis, showed low sensitivity and specificity for RR prediction, indicating low applicability of serological tests for RR prognosis. On the other hand, anti-LID-1 serology at diagnosis has shown prognostic value for ENL development in BI positive patients.engPublic Library of ScienceAntibodies, BacterialBrazilEnzyme-Linked Immunosorbent AssayImmunoglobulin GImmunoglobulin MLeprosyMycobacterium lepraePredictive Value of TestsPrognosisSensitivity and SpecificitySerologic TestsLeprosyMycobacterium lepraeSerologyDiagnosis of health situationHanseníaseMycobacterium lepraeImunoglobulina GImunoglobulina MTestes SorológicosDiagnóstico da Situação de SaúdeLeprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
title Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
spellingShingle Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
Hungria, Emerith Mayra
Antibodies, Bacterial
Brazil
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G
Immunoglobulin M
Leprosy
Mycobacterium leprae
Predictive Value of Tests
Prognosis
Sensitivity and Specificity
Serologic Tests
Leprosy
Mycobacterium leprae
Serology
Diagnosis of health situation
Hanseníase
Mycobacterium leprae
Imunoglobulina G
Imunoglobulina M
Testes Sorológicos
Diagnóstico da Situação de Saúde
title_short Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
title_full Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
title_fullStr Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
title_full_unstemmed Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
title_sort Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)
author Hungria, Emerith Mayra
author_facet Hungria, Emerith Mayra
Bührer-Sékula, Samira
Oliveira, Regiane Morillas de
Aderaldo, Lúcio Cartaxo
Pontes, Maria Araci de Andrade
Cruz, Rossilene
Gonçalves, Heitor de Sá
Penna, Maria Lucia Fernandes
Penna, Gerson Oliveira
Stefani, Mariane Martins de Araújo
author_role author
author2 Bührer-Sékula, Samira
Oliveira, Regiane Morillas de
Aderaldo, Lúcio Cartaxo
Pontes, Maria Araci de Andrade
Cruz, Rossilene
Gonçalves, Heitor de Sá
Penna, Maria Lucia Fernandes
Penna, Gerson Oliveira
Stefani, Mariane Martins de Araújo
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hungria, Emerith Mayra
Bührer-Sékula, Samira
Oliveira, Regiane Morillas de
Aderaldo, Lúcio Cartaxo
Pontes, Maria Araci de Andrade
Cruz, Rossilene
Gonçalves, Heitor de Sá
Penna, Maria Lucia Fernandes
Penna, Gerson Oliveira
Stefani, Mariane Martins de Araújo
dc.subject.mesh.pt_BR.fl_str_mv Antibodies, Bacterial
Brazil
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G
Immunoglobulin M
Leprosy
Mycobacterium leprae
Predictive Value of Tests
Prognosis
Sensitivity and Specificity
Serologic Tests
topic Antibodies, Bacterial
Brazil
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G
Immunoglobulin M
Leprosy
Mycobacterium leprae
Predictive Value of Tests
Prognosis
Sensitivity and Specificity
Serologic Tests
Leprosy
Mycobacterium leprae
Serology
Diagnosis of health situation
Hanseníase
Mycobacterium leprae
Imunoglobulina G
Imunoglobulina M
Testes Sorológicos
Diagnóstico da Situação de Saúde
dc.subject.en.pt_BR.fl_str_mv Leprosy
Mycobacterium leprae
Serology
Diagnosis of health situation
dc.subject.decs.pt_BR.fl_str_mv Hanseníase
Mycobacterium leprae
Imunoglobulina G
Imunoglobulina M
Testes Sorológicos
Diagnóstico da Situação de Saúde
description Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-05-12T14:30:34Z
dc.date.available.fl_str_mv 2020-05-12T14:30:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HUNGRI, Emerith Mayra et al. Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR). Plos Neglected Tropical Diseases, [San Francisco], v. 11, n. 2, p. 1-17, feb. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41197
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005396
identifier_str_mv HUNGRI, Emerith Mayra et al. Leprosy reactions: the predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR). Plos Neglected Tropical Diseases, [San Francisco], v. 11, n. 2, p. 1-17, feb. 2017.
1935-2727
10.1371/journal.pntd.0005396
url https://www.arca.fiocruz.br/handle/icict/41197
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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institution FIOCRUZ
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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