Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage

Ribeiro, Simone C. N.; Gomes, Lia Lima; Amaral, Eduardo P.; Andrade, Marcelle R. M.; Almeida, Fabricio M.; Rezende, Andreza L.; Lanes, Verônica R.; Carvalho, Eulógio C. Q.; Suffys, Philip Noel; Mokrousov, Igor; Lasunskaia, Elena B.

Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage

Detalhes bibliográficos
Autor(a) principal:	Ribeiro, Simone C. N.
Data de Publicação:	2014
Outros Autores:	Gomes, Lia Lima, Amaral, Eduardo P., Andrade, Marcelle R. M., Almeida, Fabricio M., Rezende, Andreza L., Lanes, Verônica R., Carvalho, Eulógio C. Q., Suffys, Philip Noel, Mokrousov, Igor, Lasunskaia, Elena B.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/10208
Resumo:	Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.

Metadados do item

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spelling	Ribeiro, Simone C. N.Gomes, Lia LimaAmaral, Eduardo P.Andrade, Marcelle R. M.Almeida, Fabricio M.Rezende, Andreza L.Lanes, Verônica R.Carvalho, Eulógio C. Q.Suffys, Philip NoelMokrousov, IgorLasunskaia, Elena B.2015-05-04T17:07:30Z2015-05-04T17:07:30Z2014RIBEIRO, Simone C. M. et al.Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage. Journal of Clinical Microbiology, v.52, n.7, p.2615-2624, 2014.1098-660Xhttps://www.arca.fiocruz.br/handle/icict/1020810.1128/JCM.00498-14engAmerican Society for MicrobiologyTuberculoseVirulênciaMycobacterium tuberculosisVirulenceTuberculosisTuberculosisVirulenciaCiências BiológicasMycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineageinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, BrasilUniversidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.St. Petersburg Pasteur Institute. Laboratory of Molecular Microbiology. St. Petersburg. Russian Federation.Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.Strains of the Beijing genotype family of Mycobacterium tuberculosis are a cause of particular concern because of their increasing dissemination in the world and their association with drug resistance. Phylogenetically, this family includes distinct ancient and modern sublineages. The modern strains, contrary to the ancestral counterparts, demonstrated increasing prevalence in many world regions that suggest an enhanced bacterial pathogenicity. We therefore evaluated virulence of modern versus ancient Beijing strains with similar epidemiological and genotype characteristics. For this, we selected six strains that had very similar 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing profiles and belonged to the region of difference 181 (RD181) subgroup but differed using markers (mutT2 and mutT4 genes and NTF locus) that discriminate between modern and ancient Beijing sublineages. The strains were isolated from native patients in Brazil and Mozambique, countries with a low prevalence of Beijing strains. The virulence levels of these strains were determined in models of pulmonary infection in mice and in vitro macrophage infection and compared with that of a strain from Russia, part of the epidemic and hypervirulent Beijing clone B0/W148, and of the laboratory strain H37Rv. The results showed that two of the three modern Beijing strains were highly pathogenic, exhibiting levels of virulence comparable with that of the epidemic Russian strain. In contrast, all isolates of the ancient sublineage displayed intermediate or low virulence. The data obtained demonstrate that the strains of the modern Beijing sublineage are more likely to exhibit highly virulent phenotypes than ancient strains and suggest that genetic alterations characteristic of the modern Beijing sublineage favor selection of highly virulent bacteria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10208/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALlia_gomesetal_IOC_2014.pdfapplication/pdf2345129https://www.arca.fiocruz.br/bitstream/icict/10208/2/lia_gomesetal_IOC_2014.pdf1b32aaff28a0f9a34cdb2bdae8526c41MD52TEXTlia_gomesetal_IOC_2014.pdf.txtlia_gomesetal_IOC_2014.pdf.txtExtracted texttext/plain54585https://www.arca.fiocruz.br/bitstream/icict/10208/3/lia_gomesetal_IOC_2014.pdf.txt1cb761d840a3ff9c404e3df94c9abf63MD53icict/102082022-06-24 13:10:43.928oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
title	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
spellingShingle	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage Ribeiro, Simone C. N. Tuberculose Virulência Mycobacterium tuberculosis Virulence Tuberculosis Tuberculosis Virulencia Ciências Biológicas
title_short	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
title_full	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
title_fullStr	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
title_full_unstemmed	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
title_sort	Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
author	Ribeiro, Simone C. N.
author_facet	Ribeiro, Simone C. N. Gomes, Lia Lima Amaral, Eduardo P. Andrade, Marcelle R. M. Almeida, Fabricio M. Rezende, Andreza L. Lanes, Verônica R. Carvalho, Eulógio C. Q. Suffys, Philip Noel Mokrousov, Igor Lasunskaia, Elena B.
author_role	author
author2	Gomes, Lia Lima Amaral, Eduardo P. Andrade, Marcelle R. M. Almeida, Fabricio M. Rezende, Andreza L. Lanes, Verônica R. Carvalho, Eulógio C. Q. Suffys, Philip Noel Mokrousov, Igor Lasunskaia, Elena B.
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Ribeiro, Simone C. N. Gomes, Lia Lima Amaral, Eduardo P. Andrade, Marcelle R. M. Almeida, Fabricio M. Rezende, Andreza L. Lanes, Verônica R. Carvalho, Eulógio C. Q. Suffys, Philip Noel Mokrousov, Igor Lasunskaia, Elena B.
dc.subject.other.pt_BR.fl_str_mv	Tuberculose Virulência
topic	Tuberculose Virulência Mycobacterium tuberculosis Virulence Tuberculosis Tuberculosis Virulencia Ciências Biológicas
dc.subject.en.pt_BR.fl_str_mv	Mycobacterium tuberculosis Virulence Tuberculosis
dc.subject.es.pt_BR.fl_str_mv	Tuberculosis Virulencia
dc.subject.decs.pt_BR.fl_str_mv	Ciências Biológicas
description	Universidade Estadual do Norte Fluminense.Laboratório de Morfologia Animal e Patologia. Laboratório de Biologia do Reconhecimento. Campos, RJ, Brasil.
publishDate	2014
dc.date.issued.fl_str_mv	2014
dc.date.accessioned.fl_str_mv	2015-05-04T17:07:30Z
dc.date.available.fl_str_mv	2015-05-04T17:07:30Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	RIBEIRO, Simone C. M. et al.Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage. Journal of Clinical Microbiology, v.52, n.7, p.2615-2624, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/10208
dc.identifier.issn.pt_BR.fl_str_mv	1098-660X
dc.identifier.doi.pt_BR.fl_str_mv	10.1128/JCM.00498-14
identifier_str_mv	RIBEIRO, Simone C. M. et al.Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage. Journal of Clinical Microbiology, v.52, n.7, p.2615-2624, 2014. 1098-660X 10.1128/JCM.00498-14
url	https://www.arca.fiocruz.br/handle/icict/10208
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	American Society for Microbiology
publisher.none.fl_str_mv	American Society for Microbiology
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/10208/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/10208/2/lia_gomesetal_IOC_2014.pdf https://www.arca.fiocruz.br/bitstream/icict/10208/3/lia_gomesetal_IOC_2014.pdf.txt
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Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage

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