Pharmacological Basis for Traditional Use of the Lippia thymoides
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23370 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Silva, Fabrício SouzaMenezes, Pedro Modesto Nascimentode Sá, Pedro Guilherme SouzaOliveira, André Luís de SantanaSouza, Eric Alencar AraújoBamberg, Vinicius Martinsde Oliveira, Henrique Ribeirode Oliveira, Sheilla AndradeAraújo, Roni Evêncio EUetanabaro, Ana Paula TrovattiSilva, Tânia Regina Dos SantosAlmeida, Jackson Roberto Guedes da SilvaLucchese, Angélica Maria2017-11-27T14:40:31Z2017-11-27T14:40:31Z2015SILVA, F. S. et al. Pharmacological Basis for Traditional Use of the Lippia thymoides. Evidence-Based Complementary and Alternative Medicine: eCAM, v. 2015, p. 463248, 2015.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/2337010.1155/2015/463248porLippiaÓleos voláteisFerimentos e LesõesFebreLippiaOils, VolatileFeverMiceWounds and InjuriesLippiaÓleos voláteisFerimentos e LesõesFebreCamundongosPharmacological Basis for Traditional Use of the Lippia thymoidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilThe aim of this study was to evaluate crude extracts and fractions from leaves and stems of Lippia thymoides and to validate their use in folk medicine. In vitro antioxidant and antimicrobial activities and in vivo wound healing in rats, baker yeast-induced fever in young rats, and acute oral toxicity in mice assays were realized. The crude extracts and their dichloromethane and ethyl acetate fractions had potent radical-scavenging activity against the DPPH but were not effective in the β-carotene bleaching method. The dichloromethane fraction from the leaves extract showed the broadest spectrum of activity against S. aureus, B. cereus, and C. parapsilosis. The animals treated with crude extracts showed no difference in wound healing when compared with the negative control group. The crude extract from leaves (1200 mg/kg) has equal efficacy in reducing temperature in rats with hyperpyrexia compared to dipyrone (240 mg/kg) and is better than paracetamol (150 mg/kg). In acute toxicity test, crude extract of leaves from Lippia thymoides exhibited no mortality and behavioral changes and no adverse effects in male and female mice. This work validates the popular use of Lippia thymoides for treating the wound and fever, providing a source for biologically active substances.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23370/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL25892998 2015 sil-pha.oa.pdf25892998 2015 sil-pha.oa.pdfapplication/pdf923236https://www.arca.fiocruz.br/bitstream/icict/23370/2/25892998%202015%20sil-pha.oa.pdfefa491ede009552b43fec1338e6363edMD52TEXT25892998 2015 sil-pha.oa.pdf.txt25892998 2015 sil-pha.oa.pdf.txtExtracted texttext/plain49305https://www.arca.fiocruz.br/bitstream/icict/23370/3/25892998%202015%20sil-pha.oa.pdf.txtaa7804871059ecf59ba11dbb0edd34a7MD53icict/233702018-08-15 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| dc.title.pt_BR.fl_str_mv |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| title |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| spellingShingle |
Pharmacological Basis for Traditional Use of the Lippia thymoides Silva, Fabrício Souza Lippia Óleos voláteis Ferimentos e Lesões Febre Lippia Oils, Volatile Fever Mice Wounds and Injuries Lippia Óleos voláteis Ferimentos e Lesões Febre Camundongos |
| title_short |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| title_full |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| title_fullStr |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| title_full_unstemmed |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| title_sort |
Pharmacological Basis for Traditional Use of the Lippia thymoides |
| author |
Silva, Fabrício Souza |
| author_facet |
Silva, Fabrício Souza Menezes, Pedro Modesto Nascimento de Sá, Pedro Guilherme Souza Oliveira, André Luís de Santana Souza, Eric Alencar Araújo Bamberg, Vinicius Martins de Oliveira, Henrique Ribeiro de Oliveira, Sheilla Andrade Araújo, Roni Evêncio E Uetanabaro, Ana Paula Trovatti Silva, Tânia Regina Dos Santos Almeida, Jackson Roberto Guedes da Silva Lucchese, Angélica Maria |
| author_role |
author |
| author2 |
Menezes, Pedro Modesto Nascimento de Sá, Pedro Guilherme Souza Oliveira, André Luís de Santana Souza, Eric Alencar Araújo Bamberg, Vinicius Martins de Oliveira, Henrique Ribeiro de Oliveira, Sheilla Andrade Araújo, Roni Evêncio E Uetanabaro, Ana Paula Trovatti Silva, Tânia Regina Dos Santos Almeida, Jackson Roberto Guedes da Silva Lucchese, Angélica Maria |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Fabrício Souza Menezes, Pedro Modesto Nascimento de Sá, Pedro Guilherme Souza Oliveira, André Luís de Santana Souza, Eric Alencar Araújo Bamberg, Vinicius Martins de Oliveira, Henrique Ribeiro de Oliveira, Sheilla Andrade Araújo, Roni Evêncio E Uetanabaro, Ana Paula Trovatti Silva, Tânia Regina Dos Santos Almeida, Jackson Roberto Guedes da Silva Lucchese, Angélica Maria |
| dc.subject.other.pt_BR.fl_str_mv |
Lippia Óleos voláteis Ferimentos e Lesões Febre |
| topic |
Lippia Óleos voláteis Ferimentos e Lesões Febre Lippia Oils, Volatile Fever Mice Wounds and Injuries Lippia Óleos voláteis Ferimentos e Lesões Febre Camundongos |
| dc.subject.en.pt_BR.fl_str_mv |
Lippia Oils, Volatile Fever Mice Wounds and Injuries |
| dc.subject.decs.pt_BR.fl_str_mv |
Lippia Óleos voláteis Ferimentos e Lesões Febre Camundongos |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2015 |
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2015 |
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2017-11-27T14:40:31Z |
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2017-11-27T14:40:31Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVA, F. S. et al. Pharmacological Basis for Traditional Use of the Lippia thymoides. Evidence-Based Complementary and Alternative Medicine: eCAM, v. 2015, p. 463248, 2015. |
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https://www.arca.fiocruz.br/handle/icict/23370 |
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1741-427X |
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10.1155/2015/463248 |
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SILVA, F. S. et al. Pharmacological Basis for Traditional Use of the Lippia thymoides. Evidence-Based Complementary and Alternative Medicine: eCAM, v. 2015, p. 463248, 2015. 1741-427X 10.1155/2015/463248 |
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