From Genome to Drugs: New Approaches in Antimicrobial Discovery

Detalhes bibliográficos
Autor(a) principal: Serral, Federico
Data de Publicação: 2021
Outros Autores: Castello, Florencia A., Sosa, Ezequiel J., Pardo, Agustín M., Palumbo, Miranda Clara, Modenutti, Carlos, Palomino, María Mercedes, Lazarowski, Alberto, Auzmendi, Jerónimo, Ramos, Pablo Ivan P., Nicolás, Marisa F., Turjanski, Adrián G., Martí, Marcelo A., Porto, Darío Fernández do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48638
Resumo: CNPq (process no. 306894/ 2019-0) and granted by CAPES (process no. 88887.368759/
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spelling Serral, FedericoCastello, Florencia A.Sosa, Ezequiel J.Pardo, Agustín M.Palumbo, Miranda ClaraModenutti, CarlosPalomino, María MercedesLazarowski, AlbertoAuzmendi, JerónimoRamos, Pablo Ivan P.Nicolás, Marisa F.Turjanski, Adrián G.Martí, Marcelo A.Porto, Darío Fernández do2021-08-17T11:03:26Z2021-08-17T11:03:26Z2021SERRAL, Federico et al. From Genome to Drugs: New Approaches in Antimicrobial Discovery. Frontiers in Pharmacology, 2021.1663-9812https://www.arca.fiocruz.br/handle/icict/4863810.3389/fphar.2021.647060CNPq (process no. 306894/ 2019-0) and granted by CAPES (process no. 88887.368759/Universidad de Buenos Aires. Instituto de Cálculo. Facultad de Ciencias Exactas y Naturales. Buenos Aires, Argentina.Universidad de Buenos Aires. Instituto de Cálculo. Facultad de Ciencias Exactas y Naturales. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica. Buenos Aires, Argentina.Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones en Fisiopatología y Bioquímica Clínica. Departamento de Bioquímica Clínica. Buenos Aires, Argentina.Consejo Nacional de Investigaciones Científicas y Técnicas. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones en Fisiopatología y Bioquímica Clínica. Departamento de Bioquímica Clínica. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Laboratório Nacional de Computação Científica. Petrópolis, Brasil.Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica. Buenos Aires, Argentina.Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica. Buenos Aires, Argentina.Universidad de Buenos Aires. Instituto de Cálculo. Facultad de Ciencias Exactas y Naturales. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Buenos Aires, Argentina.Decades of successful use of antibiotics is currently challenged by the emergence of increasingly resistant bacterial strains. Novel drugs are urgently required but, in a scenario where private investment in the development of new antimicrobials is declining, efforts to combat drug-resistant infections become a worldwide public health problem. Reasons behind unsuccessful new antimicrobial development projects range from inadequate selection of the molecular targets to a lack of innovation. In this context, increasingly available omics data for multiple pathogens has created new drug discovery and development opportunities to fight infectious diseases. Identification of an appropriate molecular target is currently accepted as a critical step of the drug discovery process. Here, we review how diverse layers of multi-omics data in conjunction with structural/ functional analysis and systems biology can be used to prioritize the best candidate proteins. Once the target is selected, virtual screening can be used as a robust methodology to explore molecular scaffolds that could act as inhibitors, guiding the development of new drug lead compounds. This review focuses on how the advent of omics and the development and application of bioinformatics strategies conduct a “bigdata era” that improves target selection and lead compound identification in a costeffective and shortened timeline.engFrontiers MediaDescoberta de drogasAntibacterianosDoenças transmissíveisInvestimentos em SaúdeBiologia computacionaldrug discovery,Drug targetMetabolic reconstructionStructural modelingTarget prioritizationVirtual screeningFrom Genome to Drugs: New Approaches in Antimicrobial Discoveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48638/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSerral, Federico From genome....pdfSerral, Federico From 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dc.title.pt_BR.fl_str_mv From Genome to Drugs: New Approaches in Antimicrobial Discovery
title From Genome to Drugs: New Approaches in Antimicrobial Discovery
spellingShingle From Genome to Drugs: New Approaches in Antimicrobial Discovery
Serral, Federico
Descoberta de drogas
Antibacterianos
Doenças transmissíveis
Investimentos em Saúde
Biologia computacional
drug discovery,
Drug target
Metabolic reconstruction
Structural modeling
Target prioritization
Virtual screening
title_short From Genome to Drugs: New Approaches in Antimicrobial Discovery
title_full From Genome to Drugs: New Approaches in Antimicrobial Discovery
title_fullStr From Genome to Drugs: New Approaches in Antimicrobial Discovery
title_full_unstemmed From Genome to Drugs: New Approaches in Antimicrobial Discovery
title_sort From Genome to Drugs: New Approaches in Antimicrobial Discovery
author Serral, Federico
author_facet Serral, Federico
Castello, Florencia A.
Sosa, Ezequiel J.
Pardo, Agustín M.
Palumbo, Miranda Clara
Modenutti, Carlos
Palomino, María Mercedes
Lazarowski, Alberto
Auzmendi, Jerónimo
Ramos, Pablo Ivan P.
Nicolás, Marisa F.
Turjanski, Adrián G.
Martí, Marcelo A.
Porto, Darío Fernández do
author_role author
author2 Castello, Florencia A.
Sosa, Ezequiel J.
Pardo, Agustín M.
Palumbo, Miranda Clara
Modenutti, Carlos
Palomino, María Mercedes
Lazarowski, Alberto
Auzmendi, Jerónimo
Ramos, Pablo Ivan P.
Nicolás, Marisa F.
Turjanski, Adrián G.
Martí, Marcelo A.
Porto, Darío Fernández do
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Serral, Federico
Castello, Florencia A.
Sosa, Ezequiel J.
Pardo, Agustín M.
Palumbo, Miranda Clara
Modenutti, Carlos
Palomino, María Mercedes
Lazarowski, Alberto
Auzmendi, Jerónimo
Ramos, Pablo Ivan P.
Nicolás, Marisa F.
Turjanski, Adrián G.
Martí, Marcelo A.
Porto, Darío Fernández do
dc.subject.other.pt_BR.fl_str_mv Descoberta de drogas
Antibacterianos
Doenças transmissíveis
Investimentos em Saúde
Biologia computacional
topic Descoberta de drogas
Antibacterianos
Doenças transmissíveis
Investimentos em Saúde
Biologia computacional
drug discovery,
Drug target
Metabolic reconstruction
Structural modeling
Target prioritization
Virtual screening
dc.subject.en.pt_BR.fl_str_mv drug discovery,
Drug target
Metabolic reconstruction
Structural modeling
Target prioritization
Virtual screening
description CNPq (process no. 306894/ 2019-0) and granted by CAPES (process no. 88887.368759/
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-17T11:03:26Z
dc.date.available.fl_str_mv 2021-08-17T11:03:26Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SERRAL, Federico et al. From Genome to Drugs: New Approaches in Antimicrobial Discovery. Frontiers in Pharmacology, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48638
dc.identifier.issn.pt_BR.fl_str_mv 1663-9812
dc.identifier.eissn.none.fl_str_mv 10.3389/fphar.2021.647060
identifier_str_mv SERRAL, Federico et al. From Genome to Drugs: New Approaches in Antimicrobial Discovery. Frontiers in Pharmacology, 2021.
1663-9812
10.3389/fphar.2021.647060
url https://www.arca.fiocruz.br/handle/icict/48638
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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