Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10080 |
Resumo: | Hospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
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Lyra, Andre CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daFortes, Marcos FragaSilva, André Goyanna PinheiroMota, Augusto César de AndradeOliveira, Sheilla Andrade deBraga, Eduardo LorensCarvalho, Wilson Andrade deGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme Costa2015-04-17T17:50:23Z2015-04-17T17:50:23Z2007LYRA, A. C. et al. Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World Journal of Gastroenterology, v. 13, n. 7, p. 1067-1073, 2007.1007-9327https://www.arca.fiocruz.br/handle/icict/10080engBaishideng Publishing Group Co. LimitedFeasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhaes. Recife, PE, BrasilHospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, BrasilBGStats Consulting. Graz, AustriaHospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilAIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained of mild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 +/- 0.9) and 4 mo (2.10 +/- 1.0) after cell transplantation that baseline levels (2.78 +/- 1.2). Albumin levels 4 mo after BMC infusion (3.73 +/- 0.5) were higher than baseline levels (3.47 +/- 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.Bone marrowCell transplantationLiver failureStem cellCirrhosisTransplante de Medula Óssea/efeitos adversosTransplante de Medula Óssea/métodosHepatopatias/terapiaAdultoIdosoBilirrubina/sangueDoença CrônicaEstudos de ViabilidadeFemininoHumanosInfusões Intra-ArteriaisHepatopatias/metabolismoMasculinoMeia-IdadeAlbumina Sérica/metabolismoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10080/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALLyra A C Feasibility and safety....pdfLyra A C Feasibility and safety....pdfapplication/pdf721437https://www.arca.fiocruz.br/bitstream/icict/10080/2/Lyra%20A%20C%20Feasibility%20%20and%20safety....pdf75ac96704d2533501891f5209c8b6837MD52TEXTLyra A C Feasibility and safety....pdf.txtLyra A C Feasibility and safety....pdf.txtExtracted texttext/plain29191https://www.arca.fiocruz.br/bitstream/icict/10080/3/Lyra%20A%20C%20Feasibility%20%20and%20safety....pdf.txt9817cbe85e96ad617a21dabab694d6d7MD53icict/100802023-03-15 14:33:22.328oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| title |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| spellingShingle |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. Lyra, Andre Castro Bone marrow Cell transplantation Liver failure Stem cell Cirrhosis Transplante de Medula Óssea/efeitos adversos Transplante de Medula Óssea/métodos Hepatopatias/terapia Adulto Idoso Bilirrubina/sangue Doença Crônica Estudos de Viabilidade Feminino Humanos Infusões Intra-Arteriais Hepatopatias/metabolismo Masculino Meia-Idade Albumina Sérica/metabolismo |
| title_short |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| title_full |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| title_fullStr |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| title_full_unstemmed |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| title_sort |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. |
| author |
Lyra, Andre Castro |
| author_facet |
Lyra, Andre Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Mota, Augusto César de Andrade Oliveira, Sheilla Andrade de Braga, Eduardo Lorens Carvalho, Wilson Andrade de Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
| author_role |
author |
| author2 |
Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Mota, Augusto César de Andrade Oliveira, Sheilla Andrade de Braga, Eduardo Lorens Carvalho, Wilson Andrade de Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lyra, Andre Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Mota, Augusto César de Andrade Oliveira, Sheilla Andrade de Braga, Eduardo Lorens Carvalho, Wilson Andrade de Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
| dc.subject.en.pt_BR.fl_str_mv |
Bone marrow Cell transplantation Liver failure Stem cell Cirrhosis |
| topic |
Bone marrow Cell transplantation Liver failure Stem cell Cirrhosis Transplante de Medula Óssea/efeitos adversos Transplante de Medula Óssea/métodos Hepatopatias/terapia Adulto Idoso Bilirrubina/sangue Doença Crônica Estudos de Viabilidade Feminino Humanos Infusões Intra-Arteriais Hepatopatias/metabolismo Masculino Meia-Idade Albumina Sérica/metabolismo |
| dc.subject.decs.pt_BR.fl_str_mv |
Transplante de Medula Óssea/efeitos adversos Transplante de Medula Óssea/métodos Hepatopatias/terapia Adulto Idoso Bilirrubina/sangue Doença Crônica Estudos de Viabilidade Feminino Humanos Infusões Intra-Arteriais Hepatopatias/metabolismo Masculino Meia-Idade Albumina Sérica/metabolismo |
| description |
Hospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
| publishDate |
2007 |
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2007 |
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2015-04-17T17:50:23Z |
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2015-04-17T17:50:23Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
LYRA, A. C. et al. Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World Journal of Gastroenterology, v. 13, n. 7, p. 1067-1073, 2007. |
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https://www.arca.fiocruz.br/handle/icict/10080 |
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1007-9327 |
| identifier_str_mv |
LYRA, A. C. et al. Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World Journal of Gastroenterology, v. 13, n. 7, p. 1067-1073, 2007. 1007-9327 |
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https://www.arca.fiocruz.br/handle/icict/10080 |
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Baishideng Publishing Group Co. Limited |
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Baishideng Publishing Group Co. Limited |
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