Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15991 |
Resumo: | p. 1067-1073 |
| id |
UFBA-2_d347d948f7125ea017191b6882de59bd |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/15991 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Lyra, André CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daFortes, Marcos FragaSilva, André Goyanna PinheiroMota, Augusto César de AndradeOliveira, Sheilla A.Braga, Eduardo LorensCarvalho, Wilson Andrade deGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme Costa2014-09-09T16:05:03Z2014-09-09T16:05:03Z20071007-9327http://repositorio.ufba.br/ri/handle/ri/15991v. 13, n. 7p. 1067-1073Aim: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. Methods: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. Results: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained of mild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. Conclusion: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. © 2007 The WJG Press. All rights reserved.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-11T13:40:25Z No. of bitstreams: 1 Andre Lyra.pdf: 427085 bytes, checksum: a87be2bae6ef02116a97eae504b96768 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:05:03Z (GMT) No. of bitstreams: 1 Andre Lyra.pdf: 427085 bytes, checksum: a87be2bae6ef02116a97eae504b96768 (MD5)Made available in DSpace on 2014-09-09T16:05:03Z (GMT). No. of bitstreams: 1 Andre Lyra.pdf: 427085 bytes, checksum: a87be2bae6ef02116a97eae504b96768 (MD5) Previous issue date: 2007http://www.wjgnet.com/1007-9327/13/1067.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABone marrowCell transplantationCirrhosisLiver failureStem cellFeasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver diseaseWorld Journal of Gastroenterologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALAndre Lyra.pdfAndre Lyra.pdfapplication/pdf427085https://repositorio.ufba.br/bitstream/ri/15991/1/Andre%20Lyra.pdfa87be2bae6ef02116a97eae504b96768MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15991/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTAndre Lyra.pdf.txtAndre Lyra.pdf.txtExtracted texttext/plain29221https://repositorio.ufba.br/bitstream/ri/15991/3/Andre%20Lyra.pdf.txt6ceebe22aff84cfd8ede6e91cee0e66bMD53ri/159912022-03-10 13:54:20.904oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-10T16:54:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| dc.title.alternative.pt_BR.fl_str_mv |
World Journal of Gastroenterology |
| title |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| spellingShingle |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease Lyra, André Castro Bone marrow Cell transplantation Cirrhosis Liver failure Stem cell |
| title_short |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| title_full |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| title_fullStr |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| title_full_unstemmed |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| title_sort |
Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease |
| author |
Lyra, André Castro |
| author_facet |
Lyra, André Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Mota, Augusto César de Andrade Oliveira, Sheilla A. Braga, Eduardo Lorens Carvalho, Wilson Andrade de Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
| author_role |
author |
| author2 |
Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Mota, Augusto César de Andrade Oliveira, Sheilla A. Braga, Eduardo Lorens Carvalho, Wilson Andrade de Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lyra, André Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Mota, Augusto César de Andrade Oliveira, Sheilla A. Braga, Eduardo Lorens Carvalho, Wilson Andrade de Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
| dc.subject.por.fl_str_mv |
Bone marrow Cell transplantation Cirrhosis Liver failure Stem cell |
| topic |
Bone marrow Cell transplantation Cirrhosis Liver failure Stem cell |
| description |
p. 1067-1073 |
| publishDate |
2007 |
| dc.date.issued.fl_str_mv |
2007 |
| dc.date.accessioned.fl_str_mv |
2014-09-09T16:05:03Z |
| dc.date.available.fl_str_mv |
2014-09-09T16:05:03Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/15991 |
| dc.identifier.issn.none.fl_str_mv |
1007-9327 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 13, n. 7 |
| identifier_str_mv |
1007-9327 v. 13, n. 7 |
| url |
http://repositorio.ufba.br/ri/handle/ri/15991 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.source.pt_BR.fl_str_mv |
http://www.wjgnet.com/1007-9327/13/1067.pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/15991/1/Andre%20Lyra.pdf https://repositorio.ufba.br/bitstream/ri/15991/2/license.txt https://repositorio.ufba.br/bitstream/ri/15991/3/Andre%20Lyra.pdf.txt |
| bitstream.checksum.fl_str_mv |
a87be2bae6ef02116a97eae504b96768 0d4b811ef71182510d2015daa7c8a900 6ceebe22aff84cfd8ede6e91cee0e66b |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1801502532625760256 |