Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29080 |
Resumo: | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. |
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Barros, L. A.Silva, M. CostaBiolchini, C. L.Neves, R. H.Silva, J. R. Machado2018-09-26T16:45:06Z2018-09-26T16:45:06Z2009BARROS, L. A. et al. Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet. Brazilian Journal of Medical and Biological Research, v. 42, p. 812-815, Sept. 2009.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/2908010.1590/s0100-879x20090009000071414-431XengAssociação Brasileira de Divulgação CientíficaSchistosoma mansoniPraziquantelDieta com Restrição de ProteínasEstereologiaSchistosoma mansoniLow-protein dietStereologyPraziquantelEffect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein dietinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, BrasilA study was undertaken to investigate the effect of administering praziquantel (PZQ), focusing on the liver stereological findings of malnourished mice infected with Schistosoma mansoni. Thirty female Swiss Webster mice (age: 21 days; weight: 8-14 g) were fed either a low-protein diet (8%) or standard chow (22% protein) for 15 days. Five mice in each group were infected with 50 cercariae each of the BH strain (Brazil). PZQ therapy (80 mg/kg body weight, per day) was started on the 50th day of infection and consisted of daily administration for 5 days. Volume density (hepatocytes, sinusoids and hepatic fibrosis) was determined by stereology using a light microscope. Body weight gain and total serum albumin levels were always lower in undernourished mice. Our stereological study demonstrated that treatment increased both volume density of hepatocytes in mice fed standard chow (47.56%, treated group and 12.06%, control) and low-protein chow (30.98%, treated group and 21.44%, control), and hepatic sinusoids [standard chow (12.52%, treated group and 9.06%, control), low-protein chow (14.42%, treated group and 8.46%, control)], while hepatic fibrosis was reduced [standard chow (39.92%, treated group and 78.88%, control) and low-protein chow (54.60%, treated group and 70.10%, control)]. On the other hand, mice fed low-protein chow decreased density volume of hepatocytes and hepatic fibrosis. In conclusion, our findings indicate that treatment with PZQ ameliorates hepatic schistosomiasis pathology even in mice fed a low-protein diet.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29080/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRH_neves_etal_IOC_2009.pdf.pdfRH_neves_etal_IOC_2009.pdf.pdfapplication/pdf387513https://www.arca.fiocruz.br/bitstream/icict/29080/2/RH_neves_etal_IOC_2009.pdf.pdfa4f2f7f0efc3b91d4176108d50aa5fe4MD52TEXTRH_neves_etal_IOC_2009.pdf.pdf.txtRH_neves_etal_IOC_2009.pdf.pdf.txtExtracted texttext/plain19843https://www.arca.fiocruz.br/bitstream/icict/29080/3/RH_neves_etal_IOC_2009.pdf.pdf.txtcd58ab5487f4a4632aa851f48147d5b1MD53icict/290802023-07-05 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dc.title.pt_BR.fl_str_mv |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
title |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
spellingShingle |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet Barros, L. A. Schistosoma mansoni Praziquantel Dieta com Restrição de Proteínas Estereologia Schistosoma mansoni Low-protein diet Stereology Praziquantel |
title_short |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
title_full |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
title_fullStr |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
title_full_unstemmed |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
title_sort |
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet |
author |
Barros, L. A. |
author_facet |
Barros, L. A. Silva, M. Costa Biolchini, C. L. Neves, R. H. Silva, J. R. Machado |
author_role |
author |
author2 |
Silva, M. Costa Biolchini, C. L. Neves, R. H. Silva, J. R. Machado |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barros, L. A. Silva, M. Costa Biolchini, C. L. Neves, R. H. Silva, J. R. Machado |
dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Praziquantel Dieta com Restrição de Proteínas Estereologia |
topic |
Schistosoma mansoni Praziquantel Dieta com Restrição de Proteínas Estereologia Schistosoma mansoni Low-protein diet Stereology Praziquantel |
dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Low-protein diet Stereology Praziquantel |
description |
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2018-09-26T16:45:06Z |
dc.date.available.fl_str_mv |
2018-09-26T16:45:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARROS, L. A. et al. Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet. Brazilian Journal of Medical and Biological Research, v. 42, p. 812-815, Sept. 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/29080 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.doi.none.fl_str_mv |
10.1590/s0100-879x2009000900007 |
dc.identifier.eissn.none.fl_str_mv |
1414-431X |
identifier_str_mv |
BARROS, L. A. et al. Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet. Brazilian Journal of Medical and Biological Research, v. 42, p. 812-815, Sept. 2009. 0100-879X 10.1590/s0100-879x2009000900007 1414-431X |
url |
https://www.arca.fiocruz.br/handle/icict/29080 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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