Cryptomeria japonica (L. F.) D. Don as source of shikimic acid

Detalhes bibliográficos
Autor(a) principal: Cerdeira, Antonio Luiz
Data de Publicação: 2020
Outros Autores: Queiroz, Sonia Claudia Nascimento, Matallo, Marcus Barifouse
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48165
Resumo: Embrapa Meio Ambiente. Jaguariúna, SP, Brasil.
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spelling Cerdeira, Antonio LuizQueiroz, Sonia Claudia NascimentoMatallo, Marcus Barifouse2021-07-12T18:21:08Z2021-07-12T18:21:08Z2020CERDEIRA, Antonio L. et al. Cryptomeria japonica (L. F.) D. Don as source of shikimic acid. Revista Fitos, Rio de Janeiro, v. 14, n. 4, p. 462-468, 2020.1808-9569https://www.arca.fiocruz.br/handle/icict/4816510.32712/2446-4775.2020.821porFundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e SaúdeCryptomeria japonica (L. F.) D. Don as source of shikimic acidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEmbrapa Meio Ambiente. Jaguariúna, SP, Brasil.Embrapa Meio Ambiente. Jaguariúna, SP, Brasil.Embrapa Meio Ambiente. Jaguariúna, SP, Brasil.Oseltamivir phosphate (OSP), marketed under the brand name of Tamiflu®, is a potent inhibitor of viral neuraminidase, a glycoside hydrolase enzyme essential for viral replication. OSP is also important to control influenza virus (H1N1) and is produced mainly from shikimic acid (SA) extracted from plants. The main source of SA is from seeds of I. verum. Alternatives to meet the worldwide demand are necessary. One of this is Cryptomeria japonica. Inthis study, we found a content of 56.36 mg.kg-1 of SA in dried biomass for C. japonica, while for I.verum, the traditional source, was 96.57 mg.kg-1. Due to the fact of C. japonica is a tree, exploited for commercial production, it can be a renewable and reliable source SA for OSP production.InfluenzaTamifluOseltamivir PhosphateNeuraminidaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/48165/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALantonio_luiz_et_all.pdfapplication/pdf265555https://www.arca.fiocruz.br/bitstream/icict/48165/2/antonio_luiz_et_all.pdf7937913f8732b3c8836410d26b54930dMD52TEXTantonio_luiz_et_all.pdf.txtantonio_luiz_et_all.pdf.txtExtracted texttext/plain17727https://www.arca.fiocruz.br/bitstream/icict/48165/3/antonio_luiz_et_all.pdf.txt9c64b060701d78f818484ac5e7b2dca6MD53icict/481652021-07-28 09:08:23.935oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-07-28T12:08:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
title Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
spellingShingle Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
Cerdeira, Antonio Luiz
Influenza
Tamiflu
Oseltamivir Phosphate
Neuraminidase
title_short Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
title_full Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
title_fullStr Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
title_full_unstemmed Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
title_sort Cryptomeria japonica (L. F.) D. Don as source of shikimic acid
author Cerdeira, Antonio Luiz
author_facet Cerdeira, Antonio Luiz
Queiroz, Sonia Claudia Nascimento
Matallo, Marcus Barifouse
author_role author
author2 Queiroz, Sonia Claudia Nascimento
Matallo, Marcus Barifouse
author2_role author
author
dc.contributor.author.fl_str_mv Cerdeira, Antonio Luiz
Queiroz, Sonia Claudia Nascimento
Matallo, Marcus Barifouse
dc.subject.en.pt_BR.fl_str_mv Influenza
Tamiflu
Oseltamivir Phosphate
Neuraminidase
topic Influenza
Tamiflu
Oseltamivir Phosphate
Neuraminidase
description Embrapa Meio Ambiente. Jaguariúna, SP, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-07-12T18:21:08Z
dc.date.available.fl_str_mv 2021-07-12T18:21:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CERDEIRA, Antonio L. et al. Cryptomeria japonica (L. F.) D. Don as source of shikimic acid. Revista Fitos, Rio de Janeiro, v. 14, n. 4, p. 462-468, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48165
dc.identifier.issn.pt_BR.fl_str_mv 1808-9569
dc.identifier.doi.pt_BR.fl_str_mv 10.32712/2446-4775.2020.821
identifier_str_mv CERDEIRA, Antonio L. et al. Cryptomeria japonica (L. F.) D. Don as source of shikimic acid. Revista Fitos, Rio de Janeiro, v. 14, n. 4, p. 462-468, 2020.
1808-9569
10.32712/2446-4775.2020.821
url https://www.arca.fiocruz.br/handle/icict/48165
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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