IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India

Detalhes bibliográficos
Autor(a) principal: Bansal, D.
Data de Publicação: 2009
Outros Autores: Herbert, F., Lim, P., Deshpande, P., Becavin, C., Guiyedi, V., de Maria, I., Rousselle, J.C., Namane, A., Jain, R., Cazenave, P.A., Mishra, G.C., Ferlini, C., Fesel, C., Benecke, A., Pied, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/213
http://dx.doi.org/10.1371/journal.pone.0008245
Resumo: We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same population
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spelling IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central IndiaAntigens, Protozoan/immunologyAutoantibodies/bloodBrain/immunologyCytokines/bloodImmunoglobulin G/immunologyImmunoglobulin M/immunologyWe investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same populationPublic Library of ScienceARCABansal, D.Herbert, F.Lim, P.Deshpande, P.Becavin, C.Guiyedi, V.de Maria, I.Rousselle, J.C.Namane, A.Jain, R.Cazenave, P.A.Mishra, G.C.Ferlini, C.Fesel, C.Benecke, A.Pied, S.2011-05-18T16:18:44Z2009-122009-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/213http://dx.doi.org/10.1371/journal.pone.0008245eng1932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:21:33Zoai:arca.igc.gulbenkian.pt:10400.7/213Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:21:33Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
title IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
spellingShingle IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
Bansal, D.
Antigens, Protozoan/immunology
Autoantibodies/blood
Brain/immunology
Cytokines/blood
Immunoglobulin G/immunology
Immunoglobulin M/immunology
title_short IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
title_full IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
title_fullStr IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
title_full_unstemmed IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
title_sort IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
author Bansal, D.
author_facet Bansal, D.
Herbert, F.
Lim, P.
Deshpande, P.
Becavin, C.
Guiyedi, V.
de Maria, I.
Rousselle, J.C.
Namane, A.
Jain, R.
Cazenave, P.A.
Mishra, G.C.
Ferlini, C.
Fesel, C.
Benecke, A.
Pied, S.
author_role author
author2 Herbert, F.
Lim, P.
Deshpande, P.
Becavin, C.
Guiyedi, V.
de Maria, I.
Rousselle, J.C.
Namane, A.
Jain, R.
Cazenave, P.A.
Mishra, G.C.
Ferlini, C.
Fesel, C.
Benecke, A.
Pied, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Bansal, D.
Herbert, F.
Lim, P.
Deshpande, P.
Becavin, C.
Guiyedi, V.
de Maria, I.
Rousselle, J.C.
Namane, A.
Jain, R.
Cazenave, P.A.
Mishra, G.C.
Ferlini, C.
Fesel, C.
Benecke, A.
Pied, S.
dc.subject.por.fl_str_mv Antigens, Protozoan/immunology
Autoantibodies/blood
Brain/immunology
Cytokines/blood
Immunoglobulin G/immunology
Immunoglobulin M/immunology
topic Antigens, Protozoan/immunology
Autoantibodies/blood
Brain/immunology
Cytokines/blood
Immunoglobulin G/immunology
Immunoglobulin M/immunology
description We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same population
publishDate 2009
dc.date.none.fl_str_mv 2009-12
2009-12-01T00:00:00Z
2011-05-18T16:18:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/213
http://dx.doi.org/10.1371/journal.pone.0008245
url http://hdl.handle.net/10400.7/213
http://dx.doi.org/10.1371/journal.pone.0008245
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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