IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/213 http://dx.doi.org/10.1371/journal.pone.0008245 |
Resumo: | We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same population |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central IndiaAntigens, Protozoan/immunologyAutoantibodies/bloodBrain/immunologyCytokines/bloodImmunoglobulin G/immunologyImmunoglobulin M/immunologyWe investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same populationPublic Library of ScienceARCABansal, D.Herbert, F.Lim, P.Deshpande, P.Becavin, C.Guiyedi, V.de Maria, I.Rousselle, J.C.Namane, A.Jain, R.Cazenave, P.A.Mishra, G.C.Ferlini, C.Fesel, C.Benecke, A.Pied, S.2011-05-18T16:18:44Z2009-122009-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/213http://dx.doi.org/10.1371/journal.pone.0008245eng1932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:21:33Zoai:arca.igc.gulbenkian.pt:10400.7/213Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:21:33Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
title |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
spellingShingle |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India Bansal, D. Antigens, Protozoan/immunology Autoantibodies/blood Brain/immunology Cytokines/blood Immunoglobulin G/immunology Immunoglobulin M/immunology |
title_short |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
title_full |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
title_fullStr |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
title_full_unstemmed |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
title_sort |
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India |
author |
Bansal, D. |
author_facet |
Bansal, D. Herbert, F. Lim, P. Deshpande, P. Becavin, C. Guiyedi, V. de Maria, I. Rousselle, J.C. Namane, A. Jain, R. Cazenave, P.A. Mishra, G.C. Ferlini, C. Fesel, C. Benecke, A. Pied, S. |
author_role |
author |
author2 |
Herbert, F. Lim, P. Deshpande, P. Becavin, C. Guiyedi, V. de Maria, I. Rousselle, J.C. Namane, A. Jain, R. Cazenave, P.A. Mishra, G.C. Ferlini, C. Fesel, C. Benecke, A. Pied, S. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Bansal, D. Herbert, F. Lim, P. Deshpande, P. Becavin, C. Guiyedi, V. de Maria, I. Rousselle, J.C. Namane, A. Jain, R. Cazenave, P.A. Mishra, G.C. Ferlini, C. Fesel, C. Benecke, A. Pied, S. |
dc.subject.por.fl_str_mv |
Antigens, Protozoan/immunology Autoantibodies/blood Brain/immunology Cytokines/blood Immunoglobulin G/immunology Immunoglobulin M/immunology |
topic |
Antigens, Protozoan/immunology Autoantibodies/blood Brain/immunology Cytokines/blood Immunoglobulin G/immunology Immunoglobulin M/immunology |
description |
We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same population |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12 2009-12-01T00:00:00Z 2011-05-18T16:18:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/213 http://dx.doi.org/10.1371/journal.pone.0008245 |
url |
http://hdl.handle.net/10400.7/213 http://dx.doi.org/10.1371/journal.pone.0008245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1932-6203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817549562323140608 |