Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56394 |
Resumo: | Instituto Gonçalo Muniz (IGM)-FIOCRUZ-Bahia). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Tropical Medicine Research Center. National Institutes of Health (NIH). Instituto Nacional de Saúde das Minorias e Disparidades de Saúde. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Pesquisa e Desenvolvimento (CNPq). Dodson da UTEP. BUILDing Scholars Program na UTEP. Frank B. Cotton Trust, UTEP Graduate School. The Allien and Paul C. Davidson Scholarship. UTEP Graduate School do Office of Scholarships. Programa NIH Research Training Initiative for Student Enhancement (RISE). Graduate School, UTEP. UTEP Graduate School. |
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Viana, Sayonara M.Montoya, Alba L.Carvalho, Augusto M.Mendonça, Brunele S. dePortillo, SusanaOlivas, Janet J.Karimi, Nasim H.Estevao, Igor L.Rodriguez, Uriel OrtegaCarvalho, Edgar M.Dutra, Walderez O.Maldonaldo, Rosa A.Michael, KatjaOliveira, Camila I. deAlmeida, Igor C.2023-01-09T13:48:45Z2023-01-09T13:48:45Z2022VIANA, Sayonara M. et al. Serodiagnosis and therapeutic monitoring of New-World tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins. Emerging Microbes & Infections, v. 11, n. 1, p. 1-14, 2022.2222-1751https://www.arca.fiocruz.br/handle/icict/5639410.1080/22221751.2022.2114852Instituto Gonçalo Muniz (IGM)-FIOCRUZ-Bahia). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Tropical Medicine Research Center. National Institutes of Health (NIH). Instituto Nacional de Saúde das Minorias e Disparidades de Saúde. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Pesquisa e Desenvolvimento (CNPq). Dodson da UTEP. BUILDing Scholars Program na UTEP. Frank B. Cotton Trust, UTEP Graduate School. The Allien and Paul C. Davidson Scholarship. UTEP Graduate School do Office of Scholarships. Programa NIH Research Training Initiative for Student Enhancement (RISE). Graduate School, UTEP. UTEP Graduate School.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Department of Chemistry and Biochemistry, Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Department of Chemistry and Biochemistry, Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil.Department of Biological Sciences. Border Biomedical Research Center. The University of Texas at El Paso. El Paso, Texas, U.S.A.American tegumentary leishmaniasis (TL) caused by Leishmania braziliensis is characterized by a spectrum of clinical presentations, ranging from localized cutaneous ulcers (CL), mucosal (ML), or disseminated (DL) disease, to a subclinical (SC) asymptomatic form. Current diagnosis based on parasite culture and/or microscopy lacks sensitivity and specificity. Previous studies showed that patients with CL and ML have very high levels of Leishmania-specific anti-α-Gal antibodies. However, the native parasite α-Gal glycotope(s) is(are) still elusive, thus they have not yet been explored for a more accurate TL diagnosis. Using a chemiluminescent immunoassay, we evaluated the seroreactivity of TL patients across its clinical spectrum, and of endemic (EC) and nonendemic healthy controls (NEC) against three synthetic neoglycoproteins (NGP29b, NGP30b, and NGP28b), respectively comprising the L. major-derived type-2 glycoinositolphospholipid (GIPL)-1 (Galfβ1,3Manα), GIPL-2 (Galα1,3Galfβ1,3Manα), and GIPL-3 (Galα1,6Galα1,3Galfβ) glycotopes. Contrary to NGP29b and NGP30b, NGP28b exhibited high sensitivity and specificity to a CL serum pool. More importantly, NGP28b reacted strongly and specifically with individual sera from distinct clinical forms of TL, especially with SC sera, with 94% sensitivity and 97% specificity, by post-two-graph receiver-operating characteristic curve analysis. Contrary to NGP29b, NGP28b showed low cross-reactivity with Chagas disease and control (NEC/EC) sera. Additionally, seroreactivity of CL patients against NGP28b was significantly decreased after successful chemotherapy, indicating that L. braziliensis-specific anti-α-Gal antibodies may serve as an early biomarker of cure in CL. Our data also points towards the applicability of L. major type-2 GIPL-3-derived Galα1,6Galα1,3Galfβ glycotope for the serological diagnosis of American TL, particularly of the subclinical form.engTaylor and Francis GroupLeishmania braziliensisLeishmaniose tegumentarBiomarcadores de diagnóstico e prognósticoNeoglicoproteínas α-GalAnticorpos anti-α-GalLeishmania braziliensisTegumentary leishmaniasisDiagnostic and prognostic biomarkersα-Gal neoglycoproteinsAnti-α-Gal antibodiesLeishmania braziliensisTegumentary leishmaniasisBiomarcadoresDiagnósticoPrognósticoGlicoproteínasAnticorposSerodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56394/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALViana, S. M. Serodiagnosis and therapeutic.pdfViana, S. M. 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| dc.title.en_US.fl_str_mv |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| title |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| spellingShingle |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins Viana, Sayonara M. Leishmania braziliensis Leishmaniose tegumentar Biomarcadores de diagnóstico e prognóstico Neoglicoproteínas α-Gal Anticorpos anti-α-Gal Leishmania braziliensis Tegumentary leishmaniasis Diagnostic and prognostic biomarkers α-Gal neoglycoproteins Anti-α-Gal antibodies Leishmania braziliensis Tegumentary leishmaniasis Biomarcadores Diagnóstico Prognóstico Glicoproteínas Anticorpos |
| title_short |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| title_full |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| title_fullStr |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| title_full_unstemmed |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| title_sort |
Serodiagnosis and therapeutic monitoring of new-world tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins |
| author |
Viana, Sayonara M. |
| author_facet |
Viana, Sayonara M. Montoya, Alba L. Carvalho, Augusto M. Mendonça, Brunele S. de Portillo, Susana Olivas, Janet J. Karimi, Nasim H. Estevao, Igor L. Rodriguez, Uriel Ortega Carvalho, Edgar M. Dutra, Walderez O. Maldonaldo, Rosa A. Michael, Katja Oliveira, Camila I. de Almeida, Igor C. |
| author_role |
author |
| author2 |
Montoya, Alba L. Carvalho, Augusto M. Mendonça, Brunele S. de Portillo, Susana Olivas, Janet J. Karimi, Nasim H. Estevao, Igor L. Rodriguez, Uriel Ortega Carvalho, Edgar M. Dutra, Walderez O. Maldonaldo, Rosa A. Michael, Katja Oliveira, Camila I. de Almeida, Igor C. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Viana, Sayonara M. Montoya, Alba L. Carvalho, Augusto M. Mendonça, Brunele S. de Portillo, Susana Olivas, Janet J. Karimi, Nasim H. Estevao, Igor L. Rodriguez, Uriel Ortega Carvalho, Edgar M. Dutra, Walderez O. Maldonaldo, Rosa A. Michael, Katja Oliveira, Camila I. de Almeida, Igor C. |
| dc.subject.other.en_US.fl_str_mv |
Leishmania braziliensis Leishmaniose tegumentar Biomarcadores de diagnóstico e prognóstico Neoglicoproteínas α-Gal Anticorpos anti-α-Gal |
| topic |
Leishmania braziliensis Leishmaniose tegumentar Biomarcadores de diagnóstico e prognóstico Neoglicoproteínas α-Gal Anticorpos anti-α-Gal Leishmania braziliensis Tegumentary leishmaniasis Diagnostic and prognostic biomarkers α-Gal neoglycoproteins Anti-α-Gal antibodies Leishmania braziliensis Tegumentary leishmaniasis Biomarcadores Diagnóstico Prognóstico Glicoproteínas Anticorpos |
| dc.subject.en.en_US.fl_str_mv |
Leishmania braziliensis Tegumentary leishmaniasis Diagnostic and prognostic biomarkers α-Gal neoglycoproteins Anti-α-Gal antibodies |
| dc.subject.decs.en_US.fl_str_mv |
Leishmania braziliensis Tegumentary leishmaniasis Biomarcadores Diagnóstico Prognóstico Glicoproteínas Anticorpos |
| description |
Instituto Gonçalo Muniz (IGM)-FIOCRUZ-Bahia). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Tropical Medicine Research Center. National Institutes of Health (NIH). Instituto Nacional de Saúde das Minorias e Disparidades de Saúde. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Pesquisa e Desenvolvimento (CNPq). Dodson da UTEP. BUILDing Scholars Program na UTEP. Frank B. Cotton Trust, UTEP Graduate School. The Allien and Paul C. Davidson Scholarship. UTEP Graduate School do Office of Scholarships. Programa NIH Research Training Initiative for Student Enhancement (RISE). Graduate School, UTEP. UTEP Graduate School. |
| publishDate |
2022 |
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2022 |
| dc.date.accessioned.fl_str_mv |
2023-01-09T13:48:45Z |
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2023-01-09T13:48:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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| dc.identifier.citation.fl_str_mv |
VIANA, Sayonara M. et al. Serodiagnosis and therapeutic monitoring of New-World tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins. Emerging Microbes & Infections, v. 11, n. 1, p. 1-14, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56394 |
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2222-1751 |
| dc.identifier.doi.none.fl_str_mv |
10.1080/22221751.2022.2114852 |
| identifier_str_mv |
VIANA, Sayonara M. et al. Serodiagnosis and therapeutic monitoring of New-World tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins. Emerging Microbes & Infections, v. 11, n. 1, p. 1-14, 2022. 2222-1751 10.1080/22221751.2022.2114852 |
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https://www.arca.fiocruz.br/handle/icict/56394 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Taylor and Francis Group |
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Taylor and Francis Group |
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