TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Frade, Amanda Farage
Data de Publicação: 2011
Outros Autores: Oliveira, Lea Campos de, Costa, Dorcas Lamounier, Costa, Carlos Henrique Nery, Aquino, Dorlene Maria Cardoso de, Van Weyenbergh, Johan Jozef Rosa Maria, Barral Netto, Manoel, Barral, Aldina Maria Prado, Kalil, Jorge, Goldberg, Anna Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7356
Resumo: Heart Institute (InCor) HC- FMUSP. Laboratory of Immunology. São Paulo, SP, Brasil
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spelling Frade, Amanda FarageOliveira, Lea Campos deCosta, Dorcas LamounierCosta, Carlos Henrique NeryAquino, Dorlene Maria Cardoso deVan Weyenbergh, Johan Jozef Rosa MariaBarral Netto, ManoelBarral, Aldina Maria PradoKalil, JorgeGoldberg, Anna Carla2014-02-26T17:26:57Z2014-02-26T17:26:57Z2011FRADE, A. F. et al. TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis. Infection, Genetics and Evolution, v. 11, p. 912–916, 2011.1567-7257https://www.arca.fiocruz.br/handle/icict/735610.1016/j.meegid.2011.02.014engElsevier B.VTGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHeart Institute (InCor) HC- FMUSP. Laboratory of Immunology. São Paulo, SP, BrasilUniversity of São Paulo. Central Institute. General Hospital. School of Medicine. Laboratory of Medicine Laboratorial. São Paulo, SP, BrasilUniversity Federal of Piauí. Teresina, PI, BrasilUniversity Federal of Piauí. Teresina, PI, BrasilUniversity Federal of Maranhão. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute for Investigation in Immunology (iii)–INCT-CNPq – Brasil. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute for Investigation in Immunology (iii)–INCT-CNPq – Brasil. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Albert Einstein Institute for Education and Research. São Paulo, SP, Brasil / Institute for Investigation in Immunology (iii)–INCT-CNPq – Brasil. BrasilHeart Institute (InCor) HC- FMUSP. Laboratory of Immunology. São Paulo, SP, Brasil / Institute for Investigation in Immunology (iii) – INCT-CNPq – Brasil. BrasilAlbert Einstein Institute for Education and Research. São Paulo, SP, Brasil / Institute for Investigation in Immunology (iii) – INCT-CNPq – Brasil. BrasilVisceral leishmaniasis (VL) or Kala-azar is a serious protozoan infectious disease caused by an obligate intracellular parasite. Cytokines have a major role in determining progression and severity of clinical manifestations in VL. We investigated polymorphisms in the TGFB1and IL8 genes, which are cytokines known to have a role in onset and severity of the disease. Polymorphisms at TGFB1 -509 C/T and +869 T/C, and IL8 -251 A/T were analyzed by a PCR-RFLP technique, in 198 patients with VL, 98 individuals with asymptomatic infection positive for a delayed-type hypersensitivity test (DTH+) and in 101 individuals with no evidence of infection (DTH-). The presence of the T allele in position -509 of the TGFB1 gene conferred a two-fold risk to develop infection both when including those with clinical symptoms (DTH+ and VL, grouped) or when considering DTH+ only, respectively p = 0.007, OR = 1.9 [1.19-3.02] and p = 0.012, OR = 2.01 [1.17-3.79], when compared with DTH- individuals. In addition, occurrence of hemorrhage was associated with TGFB1 -509 T allele. We suggest that the -509 T allele of the TGFB1 gene, a cytokine with a biologically relevant role in the natural history of the disease, may contribute to overall susceptibility to infection by Leishmania and to severity of the clinical disease.Visceral leishmaniasisCytokinesGene polymorphismsDisease susceptibilityPredisposição Genética para DoençaInterleucina-8/genéticaLeishmaniose Visceral/genéticaFator de Crescimento Transformador beta1/genéticaAdolescenteIdosoAdultoAlelosCriançaPré-EscolarFemininoGenótipoHumanosLactenteMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFrade A F TGFB1 and IL8 gene polymorphisms....pdfFrade A F TGFB1 and IL8 gene polymorphisms....pdfapplication/pdf146574https://www.arca.fiocruz.br/bitstream/icict/7356/1/Frade%20A%20F%20TGFB1%20and%20IL8%20gene%20polymorphisms....pdfbddaea5afab32bb6d1d6d5b1ad675c8eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7356/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFrade A F TGFB1 and IL8 gene polymorphisms....pdf.txtFrade A F TGFB1 and IL8 gene polymorphisms....pdf.txtExtracted texttext/plain33652https://www.arca.fiocruz.br/bitstream/icict/7356/5/Frade%20A%20F%20TGFB1%20and%20IL8%20gene%20polymorphisms....pdf.txta4a6d3869132a060d3e07b5a4308dba1MD55THUMBNAILFrade A F TGFB1 and IL8 gene polymorphisms....pdf.jpgFrade A F TGFB1 and IL8 gene polymorphisms....pdf.jpgGenerated Thumbnailimage/jpeg2321https://www.arca.fiocruz.br/bitstream/icict/7356/4/Frade%20A%20F%20TGFB1%20and%20IL8%20gene%20polymorphisms....pdf.jpgf11e0755c159adcc407dccb01437f1e5MD54icict/73562023-03-15 14:32:55.562oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
title TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
spellingShingle TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
Frade, Amanda Farage
Visceral leishmaniasis
Cytokines
Gene polymorphisms
Disease susceptibility
Predisposição Genética para Doença
Interleucina-8/genética
Leishmaniose Visceral/genética
Fator de Crescimento Transformador beta1/genética
Adolescente
Idoso
Adulto
Alelos
Criança
Pré-Escolar
Feminino
Genótipo
Humanos
Lactente
Masculino
Meia-Idade
title_short TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
title_full TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
title_fullStr TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
title_full_unstemmed TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
title_sort TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
author Frade, Amanda Farage
author_facet Frade, Amanda Farage
Oliveira, Lea Campos de
Costa, Dorcas Lamounier
Costa, Carlos Henrique Nery
Aquino, Dorlene Maria Cardoso de
Van Weyenbergh, Johan Jozef Rosa Maria
Barral Netto, Manoel
Barral, Aldina Maria Prado
Kalil, Jorge
Goldberg, Anna Carla
author_role author
author2 Oliveira, Lea Campos de
Costa, Dorcas Lamounier
Costa, Carlos Henrique Nery
Aquino, Dorlene Maria Cardoso de
Van Weyenbergh, Johan Jozef Rosa Maria
Barral Netto, Manoel
Barral, Aldina Maria Prado
Kalil, Jorge
Goldberg, Anna Carla
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Frade, Amanda Farage
Oliveira, Lea Campos de
Costa, Dorcas Lamounier
Costa, Carlos Henrique Nery
Aquino, Dorlene Maria Cardoso de
Van Weyenbergh, Johan Jozef Rosa Maria
Barral Netto, Manoel
Barral, Aldina Maria Prado
Kalil, Jorge
Goldberg, Anna Carla
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Cytokines
Gene polymorphisms
Disease susceptibility
topic Visceral leishmaniasis
Cytokines
Gene polymorphisms
Disease susceptibility
Predisposição Genética para Doença
Interleucina-8/genética
Leishmaniose Visceral/genética
Fator de Crescimento Transformador beta1/genética
Adolescente
Idoso
Adulto
Alelos
Criança
Pré-Escolar
Feminino
Genótipo
Humanos
Lactente
Masculino
Meia-Idade
dc.subject.decs.pt_BR.fl_str_mv Predisposição Genética para Doença
Interleucina-8/genética
Leishmaniose Visceral/genética
Fator de Crescimento Transformador beta1/genética
Adolescente
Idoso
Adulto
Alelos
Criança
Pré-Escolar
Feminino
Genótipo
Humanos
Lactente
Masculino
Meia-Idade
description Heart Institute (InCor) HC- FMUSP. Laboratory of Immunology. São Paulo, SP, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-02-26T17:26:57Z
dc.date.available.fl_str_mv 2014-02-26T17:26:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FRADE, A. F. et al. TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis. Infection, Genetics and Evolution, v. 11, p. 912–916, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7356
dc.identifier.issn.none.fl_str_mv 1567-7257
dc.identifier.doi.none.fl_str_mv 10.1016/j.meegid.2011.02.014
identifier_str_mv FRADE, A. F. et al. TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis. Infection, Genetics and Evolution, v. 11, p. 912–916, 2011.
1567-7257
10.1016/j.meegid.2011.02.014
url https://www.arca.fiocruz.br/handle/icict/7356
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier B.V
publisher.none.fl_str_mv Elsevier B.V
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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