Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion

Detalhes bibliográficos
Autor(a) principal: Rabelo, Kíssila
Data de Publicação: 2018
Outros Autores: Souza, Luiz J., Salomão, Natália G., Oliveira, Edson R. A., Sentinelli, Lynna de Paula, Lacerda, Marcelle S., Saraquino, Pedro B., Rosman, Fernando C., Oliveira, Rodrigo Basílio de, Carvalho, Jorge J., Paes, Marciano V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29198
Resumo: Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.
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spelling Rabelo, KíssilaSouza, Luiz J.Salomão, Natália G.Oliveira, Edson R. A.Sentinelli, Lynna de PaulaLacerda, Marcelle S.Saraquino, Pedro B.Rosman, Fernando C.Oliveira, Rodrigo Basílio deCarvalho, Jorge J.Paes, Marciano V.2018-10-01T14:53:40Z2018-10-01T14:53:40Z2018RABELO, Kissila; et al. Placental inflammation and fetal injury in a rare Zila case associated with Guillain-Barré Syndrome and abortion. Front. Microbiol., v.9, Article 1018, 10p, May 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/2919810.3389/fmicb.2018.01018engFrontiers MediaZika virusResposta imuneSyndrome de Guillain-Barréinfecção fetalhistopatologiaZika virusimmune responseGuillain-Barré syndromefetal infectionhistopathologyPlacental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisiciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil.Hospital Municipal Jesus. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisiciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Zika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barré syndrome (GBS) or congenital disorders has raised a worldwide concern. In this work, we investigated a rare Zika case, which was associated with GBS and spontaneous retained abortion. Using specific anti-ZIKV staining, the virus was identified in placenta (mainly in Hofbauer cells) and in several fetal tissues, such as brain, lungs, kidneys, skin and liver. Histological analyses of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema and necrosis in placenta, as well as tissue disorganization in the fetus. Increased cellularity (Hofbauer cells and TCD8+ lymphocytes), expression of local pro-inflammatory cytokines such as IFN-γ and TNF-α, and other markers, such as RANTES/CCL5 and VEGFR2, supported placental inflammation and dysfunction. The commitment of the maternal-fetal link in association with fetal damage gave rise to a discussion regarding the influence of the maternal immunity toward the fetal development. Findings presented in this work may help understanding the ZIKV immunopathogenesis under the rare contexts of spontaneous abortions in association with GBS.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29198/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnatalia_salomao_etal_IOC_2018.pdfnatalia_salomao_etal_IOC_2018.pdfapplication/pdf5387871https://www.arca.fiocruz.br/bitstream/icict/29198/2/natalia_salomao_etal_IOC_2018.pdfaf70373ca955c8e5399beb0fb6cffc90MD52TEXTnatalia_salomao_etal_IOC_2018.pdf.txtnatalia_salomao_etal_IOC_2018.pdf.txtExtracted texttext/plain42721https://www.arca.fiocruz.br/bitstream/icict/29198/3/natalia_salomao_etal_IOC_2018.pdf.txtf4c466d72f4fcc949c70739dcf1cf0a2MD53icict/291982018-10-02 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dc.title.pt_BR.fl_str_mv Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
title Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
spellingShingle Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
Rabelo, Kíssila
Zika virus
Resposta imune
Syndrome de Guillain-Barré
infecção fetal
histopatologia
Zika virus
immune response
Guillain-Barré syndrome
fetal infection
histopathology
title_short Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
title_full Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
title_fullStr Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
title_full_unstemmed Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
title_sort Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion
author Rabelo, Kíssila
author_facet Rabelo, Kíssila
Souza, Luiz J.
Salomão, Natália G.
Oliveira, Edson R. A.
Sentinelli, Lynna de Paula
Lacerda, Marcelle S.
Saraquino, Pedro B.
Rosman, Fernando C.
Oliveira, Rodrigo Basílio de
Carvalho, Jorge J.
Paes, Marciano V.
author_role author
author2 Souza, Luiz J.
Salomão, Natália G.
Oliveira, Edson R. A.
Sentinelli, Lynna de Paula
Lacerda, Marcelle S.
Saraquino, Pedro B.
Rosman, Fernando C.
Oliveira, Rodrigo Basílio de
Carvalho, Jorge J.
Paes, Marciano V.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rabelo, Kíssila
Souza, Luiz J.
Salomão, Natália G.
Oliveira, Edson R. A.
Sentinelli, Lynna de Paula
Lacerda, Marcelle S.
Saraquino, Pedro B.
Rosman, Fernando C.
Oliveira, Rodrigo Basílio de
Carvalho, Jorge J.
Paes, Marciano V.
dc.subject.other.pt_BR.fl_str_mv Zika virus
Resposta imune
Syndrome de Guillain-Barré
infecção fetal
histopatologia
topic Zika virus
Resposta imune
Syndrome de Guillain-Barré
infecção fetal
histopatologia
Zika virus
immune response
Guillain-Barré syndrome
fetal infection
histopathology
dc.subject.en.pt_BR.fl_str_mv Zika virus
immune response
Guillain-Barré syndrome
fetal infection
histopathology
description Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-01T14:53:40Z
dc.date.available.fl_str_mv 2018-10-01T14:53:40Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RABELO, Kissila; et al. Placental inflammation and fetal injury in a rare Zila case associated with Guillain-Barré Syndrome and abortion. Front. Microbiol., v.9, Article 1018, 10p, May 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29198
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2018.01018
identifier_str_mv RABELO, Kissila; et al. Placental inflammation and fetal injury in a rare Zila case associated with Guillain-Barré Syndrome and abortion. Front. Microbiol., v.9, Article 1018, 10p, May 2018.
1664-302X
10.3389/fmicb.2018.01018
url https://www.arca.fiocruz.br/handle/icict/29198
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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