Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36827 |
Resumo: | AR and JRC received funding for this project from New York University School of Medicine Internal Funds. |
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Correa, Juan RiveraSiqueira, Isadora Cristina deMota, SabrinaRosário, Mateus Santana doJesus, Pedro Antônio Pereira deAlcantara, Luiz Carlos JuniorErnst, Joel D.Rodriguez, Ana2019-11-04T13:11:27Z2019-11-04T13:11:27Z2019CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3682710.1371/journal.pntd.0007695AR and JRC received funding for this project from New York University School of Medicine Internal Funds.2020-01-06New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America.Hospital Santa Izabel. Salvador, BA, Brasil.Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America / University of California. Division of Experimental Medicine. San Francisco, CA, United States of America.New York University School of Medicine. Departament of Microbiology. New York, NY, USA.Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes. Using a high-throughput ELISA, we have analyzed the anti-glycolipid antibody profile, including gangliosides, of plasma samples from patients with Zika infections associated or not with GBS in Salvador, Brazil. We have observed that Zika patients that develop GBS present higher levels of anti-ganglioside antibodies when compared to Zika patients without GBS. We also observed that a broad repertoire of gangliosides was targeted by both IgM and IgG anti-self antibodies in these patients. Since Zika virus infects neurons, which contain membrane gangliosides, antigen presentation of these infected cells may trigger the observed autoimmune anti-ganglioside antibodies suggesting direct infection-induced autoantibodies as a cause leading to GBS development. Collectively, our results establish a link between anti-ganglioside antibodies and Zika-associated GBS in patients.engPublic Library of ScienceVirus zikaSíndrome de Guillain-BarréGangliosídeosBrasilZika virusGuillain-Barre SyndromeGangliosidesBrazilAnti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36827/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCorrea, R. J Anti-ganglioside.pdfCorrea, R. J Anti-ganglioside.pdfapplication/pdf1720894https://www.arca.fiocruz.br/bitstream/icict/36827/2/Correa%2c%20R.%20J%20Anti-ganglioside.pdf28c5131ba8039feee02b2c633562f927MD52TEXTCorrea, R. J Anti-ganglioside.pdf.txtCorrea, R. 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dc.title.pt_BR.fl_str_mv |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
title |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
spellingShingle |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil Correa, Juan Rivera Virus zika Síndrome de Guillain-Barré Gangliosídeos Brasil Zika virus Guillain-Barre Syndrome Gangliosides Brazil |
title_short |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
title_full |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
title_fullStr |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
title_full_unstemmed |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
title_sort |
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil |
author |
Correa, Juan Rivera |
author_facet |
Correa, Juan Rivera Siqueira, Isadora Cristina de Mota, Sabrina Rosário, Mateus Santana do Jesus, Pedro Antônio Pereira de Alcantara, Luiz Carlos Junior Ernst, Joel D. Rodriguez, Ana |
author_role |
author |
author2 |
Siqueira, Isadora Cristina de Mota, Sabrina Rosário, Mateus Santana do Jesus, Pedro Antônio Pereira de Alcantara, Luiz Carlos Junior Ernst, Joel D. Rodriguez, Ana |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Correa, Juan Rivera Siqueira, Isadora Cristina de Mota, Sabrina Rosário, Mateus Santana do Jesus, Pedro Antônio Pereira de Alcantara, Luiz Carlos Junior Ernst, Joel D. Rodriguez, Ana |
dc.subject.other.pt_BR.fl_str_mv |
Virus zika Síndrome de Guillain-Barré Gangliosídeos Brasil |
topic |
Virus zika Síndrome de Guillain-Barré Gangliosídeos Brasil Zika virus Guillain-Barre Syndrome Gangliosides Brazil |
dc.subject.en.pt_BR.fl_str_mv |
Zika virus Guillain-Barre Syndrome Gangliosides Brazil |
description |
AR and JRC received funding for this project from New York University School of Medicine Internal Funds. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-11-04T13:11:27Z |
dc.date.available.fl_str_mv |
2019-11-04T13:11:27Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36827 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0007695 |
identifier_str_mv |
CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019. 1935-2727 10.1371/journal.pntd.0007695 |
url |
https://www.arca.fiocruz.br/handle/icict/36827 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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