Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil

Detalhes bibliográficos
Autor(a) principal: Correa, Juan Rivera
Data de Publicação: 2019
Outros Autores: Siqueira, Isadora Cristina de, Mota, Sabrina, Rosário, Mateus Santana do, Jesus, Pedro Antônio Pereira de, Alcantara, Luiz Carlos Junior, Ernst, Joel D., Rodriguez, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36827
Resumo: AR and JRC received funding for this project from New York University School of Medicine Internal Funds.
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spelling Correa, Juan RiveraSiqueira, Isadora Cristina deMota, SabrinaRosário, Mateus Santana doJesus, Pedro Antônio Pereira deAlcantara, Luiz Carlos JuniorErnst, Joel D.Rodriguez, Ana2019-11-04T13:11:27Z2019-11-04T13:11:27Z2019CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3682710.1371/journal.pntd.0007695AR and JRC received funding for this project from New York University School of Medicine Internal Funds.2020-01-06New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America.Hospital Santa Izabel. Salvador, BA, Brasil.Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America / University of California. Division of Experimental Medicine. San Francisco, CA, United States of America.New York University School of Medicine. Departament of Microbiology. New York, NY, USA.Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes. Using a high-throughput ELISA, we have analyzed the anti-glycolipid antibody profile, including gangliosides, of plasma samples from patients with Zika infections associated or not with GBS in Salvador, Brazil. We have observed that Zika patients that develop GBS present higher levels of anti-ganglioside antibodies when compared to Zika patients without GBS. We also observed that a broad repertoire of gangliosides was targeted by both IgM and IgG anti-self antibodies in these patients. Since Zika virus infects neurons, which contain membrane gangliosides, antigen presentation of these infected cells may trigger the observed autoimmune anti-ganglioside antibodies suggesting direct infection-induced autoantibodies as a cause leading to GBS development. Collectively, our results establish a link between anti-ganglioside antibodies and Zika-associated GBS in patients.engPublic Library of ScienceVirus zikaSíndrome de Guillain-BarréGangliosídeosBrasilZika virusGuillain-Barre SyndromeGangliosidesBrazilAnti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36827/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCorrea, R. J Anti-ganglioside.pdfCorrea, R. J Anti-ganglioside.pdfapplication/pdf1720894https://www.arca.fiocruz.br/bitstream/icict/36827/2/Correa%2c%20R.%20J%20Anti-ganglioside.pdf28c5131ba8039feee02b2c633562f927MD52TEXTCorrea, R. J Anti-ganglioside.pdf.txtCorrea, R. 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dc.title.pt_BR.fl_str_mv Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
title Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
spellingShingle Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
Correa, Juan Rivera
Virus zika
Síndrome de Guillain-Barré
Gangliosídeos
Brasil
Zika virus
Guillain-Barre Syndrome
Gangliosides
Brazil
title_short Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
title_full Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
title_fullStr Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
title_full_unstemmed Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
title_sort Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil
author Correa, Juan Rivera
author_facet Correa, Juan Rivera
Siqueira, Isadora Cristina de
Mota, Sabrina
Rosário, Mateus Santana do
Jesus, Pedro Antônio Pereira de
Alcantara, Luiz Carlos Junior
Ernst, Joel D.
Rodriguez, Ana
author_role author
author2 Siqueira, Isadora Cristina de
Mota, Sabrina
Rosário, Mateus Santana do
Jesus, Pedro Antônio Pereira de
Alcantara, Luiz Carlos Junior
Ernst, Joel D.
Rodriguez, Ana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Correa, Juan Rivera
Siqueira, Isadora Cristina de
Mota, Sabrina
Rosário, Mateus Santana do
Jesus, Pedro Antônio Pereira de
Alcantara, Luiz Carlos Junior
Ernst, Joel D.
Rodriguez, Ana
dc.subject.other.pt_BR.fl_str_mv Virus zika
Síndrome de Guillain-Barré
Gangliosídeos
Brasil
topic Virus zika
Síndrome de Guillain-Barré
Gangliosídeos
Brasil
Zika virus
Guillain-Barre Syndrome
Gangliosides
Brazil
dc.subject.en.pt_BR.fl_str_mv Zika virus
Guillain-Barre Syndrome
Gangliosides
Brazil
description AR and JRC received funding for this project from New York University School of Medicine Internal Funds.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-11-04T13:11:27Z
dc.date.available.fl_str_mv 2019-11-04T13:11:27Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36827
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007695
identifier_str_mv CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019.
1935-2727
10.1371/journal.pntd.0007695
url https://www.arca.fiocruz.br/handle/icict/36827
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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