Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum

Detalhes bibliográficos
Autor(a) principal: Gaitán-Albarracín, Felipe
Data de Publicação: 2021
Outros Autores: Losada-Barragán, Monica, Pinho, Nathalia, Azevedo, Renata, Durães, Jonathan, Arcila-Barrera, Juan Sebástian, Menezes, Rodrigo C., Morgado, Fernanda N., Carvalho, Vinicius de Frias, Umaña-Pérez, Adriana, Cuervo, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47890
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.
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spelling Gaitán-Albarracín, FelipeLosada-Barragán, MonicaPinho, NathaliaAzevedo, RenataDurães, JonathanArcila-Barrera, Juan SebástianMenezes, Rodrigo C.Morgado, Fernanda N.Carvalho, Vinicius de FriasUmaña-Pérez, AdrianaCuervo, Patricia2021-06-28T12:28:43Z2021-06-28T12:28:43Z2021GAITÁN-ALBARRACIN, Felipe et al. Malnutrition Aggravates Alterations Observed in the Gut Structure and Immune Response of Mice Infected with Leishmania infantum. Microorganims, v. 9, p. 1-19, June 2021.2076-2607https://www.arca.fiocruz.br/handle/icict/4789010.3390/microorganisms9061270engMDPILeishmania infantumLeishmaniose visceralMá nutriçãoDuodenoInflamaçãoIgAAbsorção GastrointestinalLeishmania infantumVisceral leishmaniasisMalnutrutionGutDuodenumInflammationIgAAbsorção GastrointestinalMalnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.Universidad Antonio Nariño. Grupo de Investigación en Biología Celular y Funcional e Ingeniería de Biomoléculas. Bogotá, Colombia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil.Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. Rio de Janeiro, RJ, Brasil.Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil.Malnutrition is a risk factor for developing visceral leishmaniasis and its severe forms. Our group demonstrated that malnourished animals infected with Leishmania infantum had severe atrophies in lymphoid organs and T cell subpopulations as well as altered levels of thymic and splenic chemotactic factors, all of which resulted in dysfunctional lymphoid microenvironments that promoted parasite proliferation. Here, we hypothesize that malnutrition preceding parasite infection leads to structural and immunological changes in the gut mucosae, resulting in a failure in the immune response sensed in the intestine. To evaluate this, we analyzed the immunopathological events resulting from protein malnutrition in the guts of BALB/c mice infected with L. infantum. We observed lymphocytic/lymphoplasmacytic inflammatory infiltrates and lymphoid hyperplasia in the duodenum of well-nourished-infected mice; such alterations were worsened when malnutrition pre ceded infection. Parasite infection induced a significant increase of duodenal immunoglobulin A (IgA) of well-nourished animals, but those levels were significantly decreased in malnourished-infected mice. In addition, increased levels of Th17-related cytokines in duodenums of malnourished animals supported local inflammation. Together, our results suggest that the gut plays a potential role in re sponses to L. infantum infection—and that such responses are impaired in malnourished individual.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47890/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFelipeGAlbarracin_PatriciaCuervo_etal_IOC_2021.pdfFelipeGAlbarracin_PatriciaCuervo_etal_IOC_2021.pdfapplication/pdf4341603https://www.arca.fiocruz.br/bitstream/icict/47890/2/FelipeGAlbarracin_PatriciaCuervo_etal_IOC_2021.pdf82776f8b177db3f600122d30b42c28c3MD52TEXTFelipeGAlbarracin_PatriciaCuervo_etal_IOC_2021.pdf.txtFelipeGAlbarracin_PatriciaCuervo_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
title Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
spellingShingle Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
Gaitán-Albarracín, Felipe
Leishmania infantum
Leishmaniose visceral
Má nutrição
Duodeno
Inflamação
IgA
Absorção Gastrointestinal
Leishmania infantum
Visceral leishmaniasis
Malnutrution
Gut
Duodenum
Inflammation
IgA
Absorção Gastrointestinal
title_short Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
title_full Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
title_fullStr Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
title_full_unstemmed Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
title_sort Malnutrition aggravates alterations observed in the gut structure and immune response of mice infected with Leishmania infantum
author Gaitán-Albarracín, Felipe
author_facet Gaitán-Albarracín, Felipe
Losada-Barragán, Monica
Pinho, Nathalia
Azevedo, Renata
Durães, Jonathan
Arcila-Barrera, Juan Sebástian
Menezes, Rodrigo C.
Morgado, Fernanda N.
Carvalho, Vinicius de Frias
Umaña-Pérez, Adriana
Cuervo, Patricia
author_role author
author2 Losada-Barragán, Monica
Pinho, Nathalia
Azevedo, Renata
Durães, Jonathan
Arcila-Barrera, Juan Sebástian
Menezes, Rodrigo C.
Morgado, Fernanda N.
Carvalho, Vinicius de Frias
Umaña-Pérez, Adriana
Cuervo, Patricia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gaitán-Albarracín, Felipe
Losada-Barragán, Monica
Pinho, Nathalia
Azevedo, Renata
Durães, Jonathan
Arcila-Barrera, Juan Sebástian
Menezes, Rodrigo C.
Morgado, Fernanda N.
Carvalho, Vinicius de Frias
Umaña-Pérez, Adriana
Cuervo, Patricia
dc.subject.other.pt_BR.fl_str_mv Leishmania infantum
Leishmaniose visceral
Má nutrição
Duodeno
Inflamação
IgA
Absorção Gastrointestinal
topic Leishmania infantum
Leishmaniose visceral
Má nutrição
Duodeno
Inflamação
IgA
Absorção Gastrointestinal
Leishmania infantum
Visceral leishmaniasis
Malnutrution
Gut
Duodenum
Inflammation
IgA
Absorção Gastrointestinal
dc.subject.en.pt_BR.fl_str_mv Leishmania infantum
Visceral leishmaniasis
Malnutrution
Gut
Duodenum
Inflammation
IgA
dc.subject.decs.pt_BR.fl_str_mv Absorção Gastrointestinal
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidad Nacional de Colombia. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-28T12:28:43Z
dc.date.available.fl_str_mv 2021-06-28T12:28:43Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GAITÁN-ALBARRACIN, Felipe et al. Malnutrition Aggravates Alterations Observed in the Gut Structure and Immune Response of Mice Infected with Leishmania infantum. Microorganims, v. 9, p. 1-19, June 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47890
dc.identifier.issn.pt_BR.fl_str_mv 2076-2607
dc.identifier.doi.none.fl_str_mv 10.3390/microorganisms9061270
identifier_str_mv GAITÁN-ALBARRACIN, Felipe et al. Malnutrition Aggravates Alterations Observed in the Gut Structure and Immune Response of Mice Infected with Leishmania infantum. Microorganims, v. 9, p. 1-19, June 2021.
2076-2607
10.3390/microorganisms9061270
url https://www.arca.fiocruz.br/handle/icict/47890
dc.language.iso.fl_str_mv eng
language eng
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