Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production

Detalhes bibliográficos
Autor(a) principal: Lagrota-Candido, Jussara
Data de Publicação: 2002
Outros Autores: Vasconcellos, Rita, Cavalcanti, Marta, Bozza, Marcelo, Savino, Wilson, Quirico-Santos, Thereza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33896
Resumo: Universidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil.
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spelling Lagrota-Candido, JussaraVasconcellos, RitaCavalcanti, MartaBozza, MarceloSavino, WilsonQuirico-Santos, Thereza2019-07-09T10:51:17Z2019-07-09T10:51:17Z2002LAGROTA-CANDIDO, Jussara et al. Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production. Int. J. Exp. Path., v. 83, p. 121-132, 2002.1365-2613https://www.arca.fiocruz.br/handle/icict/3389610.1046/j.1365-2613.2002.00221.xengWileyInflamaçãoSistema ImunitárioDistrofia muscularImmune systemInflammationMdxMuscular distrophyResolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y productioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Medicina Preventiva. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil / Hospital Necker. Paris, France.Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.Mdx mouse, the animal model of Duchenne muscular dystrophy, develops an X-linked recessive inflammatory myopathy with an apparent sustained capacity for muscle regeneration. We analysed whether changes in the skeletal muscle during myonecrosis and regeneration would correlate with functional alterations in peripheral lymphoid tissues. Here we show that during the height of myonecrosis, mdx mice display marked atrophy of peripheral lymph nodes and extensive muscle inflammation. In contrast, enlargement of draining lymph nodes with accumulation of CD4+ CD44+, CD4+ CD25+, CD8+ CD44+ T lymphocytes and type-2 B cells was consistently observed during amelioration of the muscle lesion. In addition, regeneration of the muscular tissue was accompanied by concomitant increase of immunoglobulin-secreting cells in regional lymph nodes and bone marrow. Double immunolabelling analysis revealed intense B cell proliferation and formation of germinal centre in the follicles of dystrophic regional lymph nodes. Furthermore, lymph node cells produced large amounts of IFN-gamma but not IL-4, IL-6 or IL-10 after in vitro mitogen stimulation with Concanavalin A. As these alterations occurred mainly during the recovery period, we suggested that local activation of the immune system could be an influence which mitigates the myonecrosis of muscular tissue in the mdx dystrophic mouse.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33896/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_MarceloBozza_etal_IOC_2002.pdfWilsonSavino_MarceloBozza_etal_IOC_2002.pdfapplication/pdf2604365https://www.arca.fiocruz.br/bitstream/icict/33896/2/WilsonSavino_MarceloBozza_etal_IOC_2002.pdf4259b4a7048938f1eaf10d06008d88b4MD52TEXTWilsonSavino_MarceloBozza_etal_IOC_2002.pdf.txtWilsonSavino_MarceloBozza_etal_IOC_2002.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
title Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
spellingShingle Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
Lagrota-Candido, Jussara
Inflamação
Sistema Imunitário
Distrofia muscular
Immune system
Inflammation
Mdx
Muscular distrophy
title_short Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
title_full Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
title_fullStr Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
title_full_unstemmed Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
title_sort Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production
author Lagrota-Candido, Jussara
author_facet Lagrota-Candido, Jussara
Vasconcellos, Rita
Cavalcanti, Marta
Bozza, Marcelo
Savino, Wilson
Quirico-Santos, Thereza
author_role author
author2 Vasconcellos, Rita
Cavalcanti, Marta
Bozza, Marcelo
Savino, Wilson
Quirico-Santos, Thereza
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lagrota-Candido, Jussara
Vasconcellos, Rita
Cavalcanti, Marta
Bozza, Marcelo
Savino, Wilson
Quirico-Santos, Thereza
dc.subject.other.pt_BR.fl_str_mv Inflamação
Sistema Imunitário
Distrofia muscular
topic Inflamação
Sistema Imunitário
Distrofia muscular
Immune system
Inflammation
Mdx
Muscular distrophy
dc.subject.en.pt_BR.fl_str_mv Immune system
Inflammation
Mdx
Muscular distrophy
description Universidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil.
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2019-07-09T10:51:17Z
dc.date.available.fl_str_mv 2019-07-09T10:51:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAGROTA-CANDIDO, Jussara et al. Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production. Int. J. Exp. Path., v. 83, p. 121-132, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33896
dc.identifier.issn.pt_BR.fl_str_mv 1365-2613
dc.identifier.doi.pt_BR.fl_str_mv 10.1046/j.1365-2613.2002.00221.x
identifier_str_mv LAGROTA-CANDIDO, Jussara et al. Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-y production. Int. J. Exp. Path., v. 83, p. 121-132, 2002.
1365-2613
10.1046/j.1365-2613.2002.00221.x
url https://www.arca.fiocruz.br/handle/icict/33896
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/33896/3/WilsonSavino_MarceloBozza_etal_IOC_2002.pdf.txt
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