Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.

Sabino, Ester Cerdeira; Shpaer, Eugene G; Morgado, Mariza Gonçalves; Korber, Bette T. M; Diaz, Ricardo Sobhie; Bongertz, Vera; Cavalcante, Solange; Castro Filho, Bernardo Galvão; Mullins, James I; Mayer, Allen

Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.

Detalhes bibliográficos
Autor(a) principal:	Sabino, Ester Cerdeira
Data de Publicação:	1994
Outros Autores:	Shpaer, Eugene G, Morgado, Mariza Gonçalves, Korber, Bette T. M, Diaz, Ricardo Sobhie, Bongertz, Vera, Cavalcante, Solange, Castro Filho, Bernardo Galvão, Mullins, James I, Mayer, Allen
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/8214
Resumo:	Irwin Memorial Blood Centers. San Francisco, California / Instituto Adolfo Lutz. Laboratorio de Retrovirus. São Paulo, SP, Brasil

Metadados do item

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spelling	Sabino, Ester CerdeiraShpaer, Eugene GMorgado, Mariza GonçalvesKorber, Bette T. MDiaz, Ricardo SobhieBongertz, VeraCavalcante, SolangeCastro Filho, Bernardo GalvãoMullins, James IMayer, Allen2014-08-20T17:47:57Z2014-08-20T17:47:57Z1994SABINO, E. C. et al. Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil. Journal of Virology, v. 68, n. 10, p. 6340-6346, 1994.0022-538Xhttps://www.arca.fiocruz.br/handle/icict/8214engAmerican Society for MicrobiologyIdentification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIrwin Memorial Blood Centers. San Francisco, California / Instituto Adolfo Lutz. Laboratorio de Retrovirus. São Paulo, SP, BrasilUniversity School of Medicine. Department of Microbiology and Immunology. Stanford, CaliforniaIrwin Memorial Blood Centers. San Francisco, California / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, BrasilLos Alamos National Laboratory. Los Alamos, New Mexico / Santa Fe Institute. Santa Fe, New MexicoIrwin Memorial Blood Centers. San Francisco, California / Escola Paulista de Medicina. DIPA. Sao Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, BrasilUniversity School of Medicine. Department of Microbiology and Immunology. Stanford, CaliforniaIrwin Memorial Blood Centers. San Francisco, CaliforniaSequence analysis of a human immunodeficiency virus type 1 env gene PCR amplified from a Brazilian woman's peripheral blood mononuclear cell DNA (sample RJIO1) showed that it was likely to have been derived from a double recombination event between human immunodeficiency virus type 1 subtypes B and F. The major portion of the gp120 coding sequence belonged to the B lineage, but a segment of the C2 to V3 region (approximately 135 nucleotides) clearly associated with sequences of the F lineage. The subtype F-like segment had 15 noncontiguous signature nucleotides in common with Brazilian subtype F sequences that were not found, or were rare, in subtype B sequences. In contrast, this same segment had only 3 signature nucleotides shared with subtype B sequences and not present in the Brazilian subtype F sequences. Phylogenetic analysis, amino acid signature pattern analysis, and the pattern of synonymous mutations all supported the hypothesis of a recombinational origin of the RJIO1 sequence. Related recombinant genes were also detected in peripheral blood mononuclear cell DNA obtained from the woman's recent sexual partner, indicating that the recombination event probably occurred at some previous time in the chain of virus transmission. Divergent viral sequences in the V3 region were found in the male sexual partner, while a relatively homogeneous viral population was detected in the woman, consistent with her recent infectionSíndrome de Imunodeficiência Adquirida/microbiologiaProdutos do Gene env/genéticaGenes envProteína gp120 do Envelope de HIV/genéticaHIV-1/genéticaFilogeniaRecombinação GenéticaSíndrome de Imunodeficiência Adquirida/epidemiologiaSequência de AminoácidosSequência de BasesBrasil/epidemiologiaPrimers do DNAFemininoProdutos do Gene env/químicaHIV-1/classificaçãoHumanosDados de Sequência MolecularReação em Cadeia da Polimerase/métodosHomologia de Sequência de Aminoácidosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSabino E Identification of Human....pdfSabino E Identification of Human....pdfapplication/pdf1488382https://www.arca.fiocruz.br/bitstream/icict/8214/1/Sabino%20E%20Identification%20of%20Human....pdf1f98b7af2d43bf209d86069bf6d016f4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8214/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSabino E Identification of Human....pdf.txtSabino E Identification of Human....pdf.txtExtracted texttext/plain43330https://www.arca.fiocruz.br/bitstream/icict/8214/3/Sabino%20E%20Identification%20of%20Human....pdf.txtebd5ebb505ab4cf40659e92c4f2c6bbfMD53icict/82142023-03-15 14:33:21.106oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
title	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
spellingShingle	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil. Sabino, Ester Cerdeira Síndrome de Imunodeficiência Adquirida/microbiologia Produtos do Gene env/genética Genes env Proteína gp120 do Envelope de HIV/genética HIV-1/genética Filogenia Recombinação Genética Síndrome de Imunodeficiência Adquirida/epidemiologia Sequência de Aminoácidos Sequência de Bases Brasil/epidemiologia Primers do DNA Feminino Produtos do Gene env/química HIV-1/classificação Humanos Dados de Sequência Molecular Reação em Cadeia da Polimerase/métodos Homologia de Sequência de Aminoácidos
title_short	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
title_full	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
title_fullStr	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
title_full_unstemmed	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
title_sort	Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.
author	Sabino, Ester Cerdeira
author_facet	Sabino, Ester Cerdeira Shpaer, Eugene G Morgado, Mariza Gonçalves Korber, Bette T. M Diaz, Ricardo Sobhie Bongertz, Vera Cavalcante, Solange Castro Filho, Bernardo Galvão Mullins, James I Mayer, Allen
author_role	author
author2	Shpaer, Eugene G Morgado, Mariza Gonçalves Korber, Bette T. M Diaz, Ricardo Sobhie Bongertz, Vera Cavalcante, Solange Castro Filho, Bernardo Galvão Mullins, James I Mayer, Allen
author2_role	author author author author author author author author author
dc.contributor.author.fl_str_mv	Sabino, Ester Cerdeira Shpaer, Eugene G Morgado, Mariza Gonçalves Korber, Bette T. M Diaz, Ricardo Sobhie Bongertz, Vera Cavalcante, Solange Castro Filho, Bernardo Galvão Mullins, James I Mayer, Allen
dc.subject.decs.pt_BR.fl_str_mv	Síndrome de Imunodeficiência Adquirida/microbiologia Produtos do Gene env/genética Genes env Proteína gp120 do Envelope de HIV/genética HIV-1/genética Filogenia Recombinação Genética Síndrome de Imunodeficiência Adquirida/epidemiologia Sequência de Aminoácidos Sequência de Bases Brasil/epidemiologia Primers do DNA Feminino Produtos do Gene env/química HIV-1/classificação Humanos Dados de Sequência Molecular Reação em Cadeia da Polimerase/métodos Homologia de Sequência de Aminoácidos
topic	Síndrome de Imunodeficiência Adquirida/microbiologia Produtos do Gene env/genética Genes env Proteína gp120 do Envelope de HIV/genética HIV-1/genética Filogenia Recombinação Genética Síndrome de Imunodeficiência Adquirida/epidemiologia Sequência de Aminoácidos Sequência de Bases Brasil/epidemiologia Primers do DNA Feminino Produtos do Gene env/química HIV-1/classificação Humanos Dados de Sequência Molecular Reação em Cadeia da Polimerase/métodos Homologia de Sequência de Aminoácidos
description	Irwin Memorial Blood Centers. San Francisco, California / Instituto Adolfo Lutz. Laboratorio de Retrovirus. São Paulo, SP, Brasil
publishDate	1994
dc.date.issued.fl_str_mv	1994
dc.date.accessioned.fl_str_mv	2014-08-20T17:47:57Z
dc.date.available.fl_str_mv	2014-08-20T17:47:57Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SABINO, E. C. et al. Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil. Journal of Virology, v. 68, n. 10, p. 6340-6346, 1994.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/8214
dc.identifier.issn.none.fl_str_mv	0022-538X
identifier_str_mv	SABINO, E. C. et al. Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil. Journal of Virology, v. 68, n. 10, p. 6340-6346, 1994. 0022-538X
url	https://www.arca.fiocruz.br/handle/icict/8214
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	American Society for Microbiology
publisher.none.fl_str_mv	American Society for Microbiology
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.

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