Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis

Detalhes bibliográficos
Autor(a) principal: Dualib, Patricia Medic
Data de Publicação: 2022
Outros Autores: Taddei, Carla R, Fernandes, Gabriel, Carvalho, Camila R S, Sparvoli, Luiz Gustavo, Silva, Isis T, Mattar, Rosiane, Ferreira, Sandra R G, Dib, Sergio Atala, Almeida-Pititto, Bianca de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56819
Resumo: Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil.
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spelling Dualib, Patricia MedicTaddei, Carla RFernandes, GabrielCarvalho, Camila R SSparvoli, Luiz GustavoSilva, Isis TMattar, RosianeFerreira, Sandra R GDib, Sergio AtalaAlmeida-Pititto, Bianca de2023-02-01T17:26:30Z2023-02-01T17:26:30Z2022DUALIB, Patricia Medici et al. Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis. Metabolites, v. 12, n 9, 796, 2022. doi: 10.3390/metabo12090796.2218-1989https://www.arca.fiocruz.br/handle/icict/56819engMDPIGut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil.Universidade de São Paulo. Ciências e Humanidades. Departamento de Clinica e Análises Toxicológicas e Obstetricia. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Informática e Genômica DepaBiosystems. Belo Horizonte, MG, Brazil.Universidade Federal de São Paulo. Programa de Pós-Graduação em Endocrinologia e Metabologia. São Paulo, SP, Brazil.Universidade de São Paulo. Ciências e Humanidades. Departamento de Clinica e Análises Toxicológicas e Obstetricia. São Paulo, SP, Brazil.Centro Universitário Estácio de Sá. Curso de Nutrição. Belo Horizonte, MG, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina Departamento de Obstetricia. São Paulo, SP, Brazil.Universidade de São Paulo. Escola de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina Preventiva. São Paulo, SP, Brazil.The prevalence of gestational diabetes mellitus (GDM) is a global public health concern. The mechanism that leads to glucose tolerance beyond normal physiological levels to pathogenic conditions remains incompletely understood, and it is speculated that the maternal microbiome may play an important role. This study analyzes the gut microbiota composition in each trimester of weight-matched women with and without GDM and examines possible bacterial genera associations with GDM. This study followed 56 pregnant women with GDM and 59 without admitted to the outpatient clinic during their first/second or third trimester of gestation. They were submitted to a standardized questionnaire, dietary recalls, clinical examination, biological sample collection, and molecular profiling of fecal microbiota. Women with GDM were older and had a higher number of pregnancies than normal-tolerant ones. There was no difference in alpha diversity, and the groups did not differ regarding the overall microbiota structure. A higher abundance of Bacteroides in the GDM group was found. A positive correlation between Christensenellaceae and Intestinobacter abundances with one-hour post-challenge plasma glucose and a negative correlation between Enterococcus and two-hour plasma glucose levels were observed. Bifidobacterium and Peptococcus abundances were increased in the third gestational trimester for both groups. The gut microbiota composition was not dependent on the presence of GDM weight-matched women throughout gestation. However, some genera abundances showed associations with glucose metabolism. Our findings may therefore encourage a deeper understanding of physiological and pathophysiological changes in the microbiota throughout pregnancy, which could have further implications for diseases prevention.gestational diabetes mellitusgut microbiotaobesitypregnancyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56819/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGut Microbiota across Normal Gestation and Gestational Diabetes Mellitus.pdfGut Microbiota across Normal Gestation and Gestational Diabetes Mellitus.pdfapplication/pdf5014151https://www.arca.fiocruz.br/bitstream/icict/56819/2/Gut%20Microbiota%20across%20Normal%20Gestation%20and%20Gestational%20Diabetes%20Mellitus.pdf59fab6ac1d464d43b92e6e75dd114bf1MD52icict/568192023-02-01 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dc.title.en_US.fl_str_mv Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
title Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
spellingShingle Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
Dualib, Patricia Medic
gestational diabetes mellitus
gut microbiota
obesity
pregnancy
title_short Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
title_full Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
title_fullStr Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
title_full_unstemmed Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
title_sort Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
author Dualib, Patricia Medic
author_facet Dualib, Patricia Medic
Taddei, Carla R
Fernandes, Gabriel
Carvalho, Camila R S
Sparvoli, Luiz Gustavo
Silva, Isis T
Mattar, Rosiane
Ferreira, Sandra R G
Dib, Sergio Atala
Almeida-Pititto, Bianca de
author_role author
author2 Taddei, Carla R
Fernandes, Gabriel
Carvalho, Camila R S
Sparvoli, Luiz Gustavo
Silva, Isis T
Mattar, Rosiane
Ferreira, Sandra R G
Dib, Sergio Atala
Almeida-Pititto, Bianca de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dualib, Patricia Medic
Taddei, Carla R
Fernandes, Gabriel
Carvalho, Camila R S
Sparvoli, Luiz Gustavo
Silva, Isis T
Mattar, Rosiane
Ferreira, Sandra R G
Dib, Sergio Atala
Almeida-Pititto, Bianca de
dc.subject.en.en_US.fl_str_mv gestational diabetes mellitus
gut microbiota
obesity
pregnancy
topic gestational diabetes mellitus
gut microbiota
obesity
pregnancy
description Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-02-01T17:26:30Z
dc.date.available.fl_str_mv 2023-02-01T17:26:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DUALIB, Patricia Medici et al. Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis. Metabolites, v. 12, n 9, 796, 2022. doi: 10.3390/metabo12090796.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56819
dc.identifier.issn.en_US.fl_str_mv 2218-1989
identifier_str_mv DUALIB, Patricia Medici et al. Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis. Metabolites, v. 12, n 9, 796, 2022. doi: 10.3390/metabo12090796.
2218-1989
url https://www.arca.fiocruz.br/handle/icict/56819
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56819/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56819/2/Gut%20Microbiota%20across%20Normal%20Gestation%20and%20Gestational%20Diabetes%20Mellitus.pdf
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