Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56819 |
Resumo: | Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil. |
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Dualib, Patricia MedicTaddei, Carla RFernandes, GabrielCarvalho, Camila R SSparvoli, Luiz GustavoSilva, Isis TMattar, RosianeFerreira, Sandra R GDib, Sergio AtalaAlmeida-Pititto, Bianca de2023-02-01T17:26:30Z2023-02-01T17:26:30Z2022DUALIB, Patricia Medici et al. Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis. Metabolites, v. 12, n 9, 796, 2022. doi: 10.3390/metabo12090796.2218-1989https://www.arca.fiocruz.br/handle/icict/56819engMDPIGut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil.Universidade de São Paulo. Ciências e Humanidades. Departamento de Clinica e Análises Toxicológicas e Obstetricia. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Informática e Genômica DepaBiosystems. Belo Horizonte, MG, Brazil.Universidade Federal de São Paulo. Programa de Pós-Graduação em Endocrinologia e Metabologia. São Paulo, SP, Brazil.Universidade de São Paulo. Ciências e Humanidades. Departamento de Clinica e Análises Toxicológicas e Obstetricia. São Paulo, SP, Brazil.Centro Universitário Estácio de Sá. Curso de Nutrição. Belo Horizonte, MG, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina Departamento de Obstetricia. São Paulo, SP, Brazil.Universidade de São Paulo. Escola de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina Preventiva. São Paulo, SP, Brazil.The prevalence of gestational diabetes mellitus (GDM) is a global public health concern. The mechanism that leads to glucose tolerance beyond normal physiological levels to pathogenic conditions remains incompletely understood, and it is speculated that the maternal microbiome may play an important role. This study analyzes the gut microbiota composition in each trimester of weight-matched women with and without GDM and examines possible bacterial genera associations with GDM. This study followed 56 pregnant women with GDM and 59 without admitted to the outpatient clinic during their first/second or third trimester of gestation. They were submitted to a standardized questionnaire, dietary recalls, clinical examination, biological sample collection, and molecular profiling of fecal microbiota. Women with GDM were older and had a higher number of pregnancies than normal-tolerant ones. There was no difference in alpha diversity, and the groups did not differ regarding the overall microbiota structure. A higher abundance of Bacteroides in the GDM group was found. A positive correlation between Christensenellaceae and Intestinobacter abundances with one-hour post-challenge plasma glucose and a negative correlation between Enterococcus and two-hour plasma glucose levels were observed. Bifidobacterium and Peptococcus abundances were increased in the third gestational trimester for both groups. The gut microbiota composition was not dependent on the presence of GDM weight-matched women throughout gestation. However, some genera abundances showed associations with glucose metabolism. Our findings may therefore encourage a deeper understanding of physiological and pathophysiological changes in the microbiota throughout pregnancy, which could have further implications for diseases prevention.gestational diabetes mellitusgut microbiotaobesitypregnancyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56819/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGut Microbiota across Normal Gestation and Gestational Diabetes Mellitus.pdfGut Microbiota across Normal Gestation and Gestational Diabetes Mellitus.pdfapplication/pdf5014151https://www.arca.fiocruz.br/bitstream/icict/56819/2/Gut%20Microbiota%20across%20Normal%20Gestation%20and%20Gestational%20Diabetes%20Mellitus.pdf59fab6ac1d464d43b92e6e75dd114bf1MD52icict/568192023-02-01 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dc.title.en_US.fl_str_mv |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
title |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
spellingShingle |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis Dualib, Patricia Medic gestational diabetes mellitus gut microbiota obesity pregnancy |
title_short |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
title_full |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
title_fullStr |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
title_full_unstemmed |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
title_sort |
Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis |
author |
Dualib, Patricia Medic |
author_facet |
Dualib, Patricia Medic Taddei, Carla R Fernandes, Gabriel Carvalho, Camila R S Sparvoli, Luiz Gustavo Silva, Isis T Mattar, Rosiane Ferreira, Sandra R G Dib, Sergio Atala Almeida-Pititto, Bianca de |
author_role |
author |
author2 |
Taddei, Carla R Fernandes, Gabriel Carvalho, Camila R S Sparvoli, Luiz Gustavo Silva, Isis T Mattar, Rosiane Ferreira, Sandra R G Dib, Sergio Atala Almeida-Pititto, Bianca de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dualib, Patricia Medic Taddei, Carla R Fernandes, Gabriel Carvalho, Camila R S Sparvoli, Luiz Gustavo Silva, Isis T Mattar, Rosiane Ferreira, Sandra R G Dib, Sergio Atala Almeida-Pititto, Bianca de |
dc.subject.en.en_US.fl_str_mv |
gestational diabetes mellitus gut microbiota obesity pregnancy |
topic |
gestational diabetes mellitus gut microbiota obesity pregnancy |
description |
Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Medicina. São Paulo, SP, Brazil. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-02-01T17:26:30Z |
dc.date.available.fl_str_mv |
2023-02-01T17:26:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DUALIB, Patricia Medici et al. Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis. Metabolites, v. 12, n 9, 796, 2022. doi: 10.3390/metabo12090796. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/56819 |
dc.identifier.issn.en_US.fl_str_mv |
2218-1989 |
identifier_str_mv |
DUALIB, Patricia Medici et al. Gut Microbiota across Normal Gestation and Gestational Diabetes Mellitus: A Cohort Analysis. Metabolites, v. 12, n 9, 796, 2022. doi: 10.3390/metabo12090796. 2218-1989 |
url |
https://www.arca.fiocruz.br/handle/icict/56819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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