The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies

Detalhes bibliográficos
Autor(a) principal: Dualib, Patricia Medici
Data de Publicação: 2022
Outros Autores: Fernandes, Gabriel, Taddei, Carla R, Carvalho, Camila R S, Sparvoli, Luiz Gustavo, Bittencourt, Célia, Silva, Isis T, Mattar, Rosiane, Ferreira, Sandra R G, Dib, Sergio A, Almeida-Pititto, Bianca de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56935
Resumo: Department of Medicine. Escola Paulista Medicina. Universidade Federal de São Paulo. São Paulo, SP, Brazil.
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spelling Dualib, Patricia MediciFernandes, GabrielTaddei, Carla RCarvalho, Camila R SSparvoli, Luiz GustavoBittencourt, CéliaSilva, Isis TMattar, RosianeFerreira, Sandra R GDib, Sergio AAlmeida-Pititto, Bianca de2023-02-07T18:06:24Z2023-02-07T18:06:24Z2022DUALIB, Patricia Medici et al. The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies. Diabetol Metab Syndr., v. 14, n. 1, 194, 2022. doi: 10.1186/s13098-022-00954-2.1758-5996https://www.arca.fiocruz.br/handle/icict/56935engBioMed CentralThe gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Medicine. Escola Paulista Medicina. Universidade Federal de São Paulo. São Paulo, SP, Brazil.DepaBiosystems Informatics and Genomics Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Department of Clinical and Toxicological Analysis. Universidade de São Paulo. São Paulo, SP, Brazil.Graduate Program in Endocrinology and Metabology. Universidade Federal de São Paulo. São Paulo, SP, Brazil.Department of Clinical and Toxicological Analysis. Universidade de São Paulo. São Paulo, SP, Brazil.Graduate Program in Endocrinology and Metabology. Universidade Federal de São Paulo. São Paulo, SP, Brazil.Nutrition Course. Centro Universitário Estácio de Sá. Belo Horizonte, MG, Brazil.Departament of Obstetrics. Escola Paulista de Medicina. Universidade Federal de São Paulo. São Paulo, SP, Brazil.Department of Epidemiology. School of Public Health. Universidade de São Paulo. São Paulo, SP, Brazil.Department of Medicine. Escola Paulista Medicina. Universidade Federal de São Paulo. São Paulo, SP, Brazil.Department of Preventive Medicine. Escola Paulista de Medicina. Universidade Federal de São Paulo. São Paulo, SP, Brazil.Background: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide, and has been associated with some changes in the gut microbiota. Studies have shown that the maternal gut microbiota pattern with hyperglycemia can be transmitted to the offspring. The study aimed to evaluate the gut microbiota of obese postpartum women with and without previous GDM and their offspring. Methods: We evaluated a total of 84 puerperal women who had (n = 40) or not GDM (n = 44), and their infants were also included. Stool samples were obtained 2-6 months after delivery. The molecular profile of the fecal microbiota was obtained by sequencing V4 region of 16S rRNA gene (Illumina® MiSeq). Results: We found that the gut microbiota structures of the puerperal women and their infants were similar. Stratifying according to the type of delivery, the relative abundance of Victivallis genus was higher in women who had natural delivery. Exposure to exclusive breastfeeding was associated with a greater abundance of Bacteroides and Staphylococcus. The differential abundance test showed correlations to clinical and laboratory parameters. This work showed no difference in the microbiota of obese puerperal women with and without GDM and their offspring. However, breastfeeding contributed to the ecological succession of the intestinal microbiota of the offspring. Conclusion: This work can contribute to understanding the potential effects of GDM and early life events on the gut microbiome of mothers and their offspring and its possible role in metabolism later in life.BreastfeedingEarly life eventsGestational diabetes mellitusGut microbiotaObesityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56935/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThe gut microbiome of obese postpartum women.pdfThe gut microbiome of obese postpartum women.pdfapplication/pdf1206225https://www.arca.fiocruz.br/bitstream/icict/56935/2/The%20gut%20microbiome%20of%20obese%20postpartum%20women.pdffd66dd014b1a0d060e4ed67d893e85a9MD52icict/569352023-02-07 15:06:25.825oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
title The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
spellingShingle The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
Dualib, Patricia Medici
Breastfeeding
Early life events
Gestational diabetes mellitus
Gut microbiota
Obesity
title_short The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
title_full The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
title_fullStr The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
title_full_unstemmed The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
title_sort The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies
author Dualib, Patricia Medici
author_facet Dualib, Patricia Medici
Fernandes, Gabriel
Taddei, Carla R
Carvalho, Camila R S
Sparvoli, Luiz Gustavo
Bittencourt, Célia
Silva, Isis T
Mattar, Rosiane
Ferreira, Sandra R G
Dib, Sergio A
Almeida-Pititto, Bianca de
author_role author
author2 Fernandes, Gabriel
Taddei, Carla R
Carvalho, Camila R S
Sparvoli, Luiz Gustavo
Bittencourt, Célia
Silva, Isis T
Mattar, Rosiane
Ferreira, Sandra R G
Dib, Sergio A
Almeida-Pititto, Bianca de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dualib, Patricia Medici
Fernandes, Gabriel
Taddei, Carla R
Carvalho, Camila R S
Sparvoli, Luiz Gustavo
Bittencourt, Célia
Silva, Isis T
Mattar, Rosiane
Ferreira, Sandra R G
Dib, Sergio A
Almeida-Pititto, Bianca de
dc.subject.en.en_US.fl_str_mv Breastfeeding
Early life events
Gestational diabetes mellitus
Gut microbiota
Obesity
topic Breastfeeding
Early life events
Gestational diabetes mellitus
Gut microbiota
Obesity
description Department of Medicine. Escola Paulista Medicina. Universidade Federal de São Paulo. São Paulo, SP, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-02-07T18:06:24Z
dc.date.available.fl_str_mv 2023-02-07T18:06:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DUALIB, Patricia Medici et al. The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies. Diabetol Metab Syndr., v. 14, n. 1, 194, 2022. doi: 10.1186/s13098-022-00954-2.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56935
dc.identifier.issn.en_US.fl_str_mv 1758-5996
identifier_str_mv DUALIB, Patricia Medici et al. The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies. Diabetol Metab Syndr., v. 14, n. 1, 194, 2022. doi: 10.1186/s13098-022-00954-2.
1758-5996
url https://www.arca.fiocruz.br/handle/icict/56935
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56935/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56935/2/The%20gut%20microbiome%20of%20obese%20postpartum%20women.pdf
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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