Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2015
Outros Autores: Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13677
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Mendonça, Vitor Rosa Ramos deBarral Netto, Manoel2016-04-11T19:18:40Z2016-04-11T19:18:40Z2015MENDONÇA, V. R.; BARRAL-NETTO, M. Immunoregulation in human malaria: the challenge of understanding asymptomatic infection. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 945-955, 2015.1678-806010.1590/0074-02760150241https://www.arca.fiocruz.br/handle/icict/13677engInstituto Oswaldo CruzImmunoregulation in human malaria: the challenge of understanding asymptomatic infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAsymptomatic Plasmodium infection carriers represent a major threat to malaria control worldwide as they are silent natural reservoirs and do not seek medical care. There are no standard criteria for asymptomaticPlasmodium infection; therefore, its diagnosis relies on the presence of the parasite during a specific period of symptomless infection. The antiparasitic immune response can result in reducedPlasmodium sp. load with control of disease manifestations, which leads to asymptomatic infection. Both the innate and adaptive immune responses seem to play major roles in asymptomatic Plasmodiuminfection; T regulatory cell activity (through the production of interleukin-10 and transforming growth factor-ß) and B-cells (with a broad antibody response) both play prominent roles. Furthermore, molecules involved in the haem detoxification pathway (such as haptoglobin and haeme oxygenase-1) and iron metabolism (ferritin and activated c-Jun N-terminal kinase) have emerged in recent years as potential biomarkers and thus are helping to unravel the immune response underlying asymptomatic Plasmodium infection. The acquisition of large data sets and the use of robust statistical tools, including network analysis, associated with well-designed malaria studies will likely help elucidate the immune mechanisms responsible for asymptomatic infection.Asymptomatic infectionImmune responseBiomarkersNetworksinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMendonça, VR Immunoregulation in human.....pdfMendonça, VR Immunoregulation in human.....pdfapplication/pdf437541https://www.arca.fiocruz.br/bitstream/icict/13677/2/Mendon%c3%a7a%2c%20VR%20%20Immunoregulation%20in%20human.....pdf6727d65773174dfcd9e0bdddbf4b6db1MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13677/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTMendonça, VR Immunoregulation in human.....pdf.txtMendonça, VR Immunoregulation in human.....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
title Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
spellingShingle Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
Mendonça, Vitor Rosa Ramos de
Asymptomatic infection
Immune response
Biomarkers
Networks
title_short Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
title_full Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
title_fullStr Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
title_full_unstemmed Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
title_sort Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Barral Netto, Manoel
author_role author
author2 Barral Netto, Manoel
author2_role author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Asymptomatic infection
Immune response
Biomarkers
Networks
topic Asymptomatic infection
Immune response
Biomarkers
Networks
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-11T19:18:40Z
dc.date.available.fl_str_mv 2016-04-11T19:18:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, V. R.; BARRAL-NETTO, M. Immunoregulation in human malaria: the challenge of understanding asymptomatic infection. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 945-955, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13677
dc.identifier.issn.none.fl_str_mv 1678-8060
10.1590/0074-02760150241
identifier_str_mv MENDONÇA, V. R.; BARRAL-NETTO, M. Immunoregulation in human malaria: the challenge of understanding asymptomatic infection. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 945-955, 2015.
1678-8060
10.1590/0074-02760150241
url https://www.arca.fiocruz.br/handle/icict/13677
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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