A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16564 |
Resumo: | AUXPE. CAPES. FAPESB 2072/2013/PROCESSO#23038.006718/2013-19 and Fundação Oswaldo Cruz |
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Santos, Silvana OrnelasFontes, Jonathan Luís MagalhãesLaranjeira, Daniela FariasVassallo, JoséMelo, Stella Maria BarrouindosSantos, Washington Luis Conrado2016-12-26T19:23:47Z2016-12-26T19:23:47Z2016SANTOS, S. O. et al. A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection. Comparative Immunology, Microbiology and Infectious Diseases, v. 48, p. 87–92, 2016.0147-9571https://www.arca.fiocruz.br/handle/icict/1656410.1016/j.cimid.2016.08.007AUXPE. CAPES. FAPESB 2072/2013/PROCESSO#23038.006718/2013-19 and Fundação Oswaldo CruzFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital de Medicina Veterinária. Laboratório de Infectologia Veterinária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital de Medicina Veterinária. Laboratório de Infectologia Veterinária. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Departmento de Anatomia, Patologia and Clínicas. Salvador, BA, BrasilUNICAMP. Faculdade de Ciências Médicas. Campinas, SP, BrasilUniversidade Federal da Bahia. Hospital de Medicina Veterinária. Laboratório de Infectologia Veterinária. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Departmento de Anatomia, Patologia and Clínicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSevere forms of zoonotic visceral leishmaniosis (ZVL) are associated with disruption of the spleen structure. However, the study of spleen histology requires splenectomy or necropsy. In this work, we present a minimally invasive cell-block technique for studying spleen tissue histology in dogs with ZVL. We examined 13 dogs with and seven dogs without Leishmania infantum infection. The dogs with Leishmania infection had a lower frequency of lymphoid follicles (2/13, Fisher's test, P<0.02) and a higher density of plasma cells (score 3, Fisher's test, P<0.02) than uninfected dogs (5/7 exhibiting lymphoid follicles and a plasma cell score of 1). The dogs with Leishmania infection also presented with granulomas (8/13) and infected macrophages (5/13). These differences in the histological presentations of spleen tissue from infected and uninfected dogs corresponded to changes observed in conventional histology. Hence, the cell-block technique described here may be used in the follow-up care and study of dogs with ZVL and other diseases in both clinical practice and research.engElsevierLeishmania infantumCãoLeishmaniose visceral caninaBaçoBloco celularBiopsia com agulha finaHistopatologiaLeishmania infantumDogCanine visceral leishmaniasisSpleenCell blockFine-needle biopsyMinimally invasive histopathologyaA minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16564/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos SO A minimally invasive....pdfSantos SO A minimally 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| dc.title.pt_BR.fl_str_mv |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| title |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| spellingShingle |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection Santos, Silvana Ornelas Leishmania infantum Cão Leishmaniose visceral canina Baço Bloco celular Biopsia com agulha fina Histopatologia Leishmania infantum Dog Canine visceral leishmaniasis Spleen Cell block Fine-needle biopsy Minimally invasive histopathologya |
| title_short |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| title_full |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| title_fullStr |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| title_full_unstemmed |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| title_sort |
A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection |
| author |
Santos, Silvana Ornelas |
| author_facet |
Santos, Silvana Ornelas Fontes, Jonathan Luís Magalhães Laranjeira, Daniela Farias Vassallo, José Melo, Stella Maria Barrouin dosSantos, Washington Luis Conrado |
| author_role |
author |
| author2 |
Fontes, Jonathan Luís Magalhães Laranjeira, Daniela Farias Vassallo, José Melo, Stella Maria Barrouin dosSantos, Washington Luis Conrado |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Silvana Ornelas Fontes, Jonathan Luís Magalhães Laranjeira, Daniela Farias Vassallo, José Melo, Stella Maria Barrouin dosSantos, Washington Luis Conrado |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania infantum Cão Leishmaniose visceral canina Baço Bloco celular Biopsia com agulha fina Histopatologia |
| topic |
Leishmania infantum Cão Leishmaniose visceral canina Baço Bloco celular Biopsia com agulha fina Histopatologia Leishmania infantum Dog Canine visceral leishmaniasis Spleen Cell block Fine-needle biopsy Minimally invasive histopathologya |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania infantum Dog Canine visceral leishmaniasis Spleen Cell block Fine-needle biopsy Minimally invasive histopathologya |
| description |
AUXPE. CAPES. FAPESB 2072/2013/PROCESSO#23038.006718/2013-19 and Fundação Oswaldo Cruz |
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2016 |
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2016-12-26T19:23:47Z |
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2016-12-26T19:23:47Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
SANTOS, S. O. et al. A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection. Comparative Immunology, Microbiology and Infectious Diseases, v. 48, p. 87–92, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16564 |
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0147-9571 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.cimid.2016.08.007 |
| identifier_str_mv |
SANTOS, S. O. et al. A minimally invasive approach to spleen histopathology in dogs: A new method for follow-up studies of spleen changes in the course of Leishmania infantum infection. Comparative Immunology, Microbiology and Infectious Diseases, v. 48, p. 87–92, 2016. 0147-9571 10.1016/j.cimid.2016.08.007 |
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