Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis

Detalhes bibliográficos
Autor(a) principal: Moraes, Isabel Matos Medeiros de
Data de Publicação: 2018
Outros Autores: Albuquerque, Cassiano Felippe Gonçalves de, Kurz, Angela R .M., Oliveira, Flora Magno de Jesus, Abreu, Victor Hugo Pereira de, Torres, Rafael Carvalho, Carvalho, Vinícius Frias, Estato, Vanessa, Bozza, Patrícia Torres, Sperandio, Markus, Faria Neto, Hugo Caire, Silva, Adriana Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31636
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
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spelling Moraes, Isabel Matos Medeiros deAlbuquerque, Cassiano Felippe Gonçalves deKurz, Angela R .M.Oliveira, Flora Magno de JesusAbreu, Victor Hugo Pereira deTorres, Rafael CarvalhoCarvalho, Vinícius FriasEstato, VanessaBozza, Patrícia TorresSperandio, MarkusFaria Neto, Hugo CaireSilva, Adriana Ribeiro2019-02-14T12:36:34Z2019-02-14T12:36:34Z2018MORAES, Isabel Matos Medeiros de; et al. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 6053492, 13p, 2018.1942-0900https://www.arca.fiocruz.br/handle/icict/3163610.1155/2018/60534921942-0994engHindawi Publishing CorporationÁcido Oleico Omega-9AzeiteInflamaçãoSepse ExperimentalOmega-9 Oleic AcidOlive OilInflamamationExperimental sepsisOmega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto Biomédico. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Ludwig Maximilians University München. Walter Brendel Centre. Klinikum der Universität, Germany / The Centenary Institute. Camperdown, New South Wales, Australia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Estado do Rio de Janeiro. Instituto Biomédico. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Ludwig Maximilians University München. Walter Brendel Centre. Klinikum der Universität, Germany / German Center for Cardiovascular Research (DZHK) Partner Site. Munich Heart Alliance. Munich, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Estácio de Sá, Programa de Produtividade Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Sepsis is initiated by the host response to infection with organ damage, increased plasma free fatty acids, high levels of cortisol, massive cytokine production, leukocyte activation, and endothelial dysfunction. We aimed to analyze the effect of omega-9 supplementation on corticosteroid unbalance, inflammation, bacterial elimination, and peroxisome proliferator-activated receptor (PPAR) gamma expression, an omega-9 receptor and inflammatory modulator. We treated mice for 14 days with omega-9 and induced sepsis by cecal ligation and puncture (CLP). We measured systemic corticosterone levels, cytokine production, leukocyte and bacterial counts in the peritoneum, and the expression of PPAR gamma in both liver and adipose tissues during experimental sepsis. We further studied omega-9 effects on leukocyte rolling in mouse cremaster muscle-inflamed postcapillary venules and in the cerebral microcirculation of septic mice. Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-α and IL-1β in peritoneal lavage fluid of mice with sepsis. Omega-9 treatment also decreased systemic corticosterone levels. Neutrophil migration from circulation to the peritoneal cavity and leukocyte rolling on the endothelium were decreased by omega-9 treatment. Omega-9 also decreased bacterial load in the peritoneal lavage and restored liver and adipose tissue PPAR gamma expression in septic animals. Our data suggest a beneficial anti-inflammatory role of omega-9 in sepsis, mitigating leukocyte rolling and leukocyte influx, balancing cytokine production, and controlling bacterial growth possibly through a PPAR gamma expression-dependent mechanism. The significant reduction of inflammation detected after omega-9 enteral injection can further contribute to the already known beneficial properties facilitated by unsaturated fatty acid-enriched diets.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31636/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALisabelmatos_moraes_etal_IOC_2018.pdfisabelmatos_moraes_etal_IOC_2018.pdfapplication/pdf5971935https://www.arca.fiocruz.br/bitstream/icict/31636/2/isabelmatos_moraes_etal_IOC_2018.pdf4aae197cb597d01098aa3ff6b3598436MD52TEXTisabelmatos_moraes_etal_IOC_2018.pdf.txtisabelmatos_moraes_etal_IOC_2018.pdf.txtExtracted texttext/plain63283https://www.arca.fiocruz.br/bitstream/icict/31636/3/isabelmatos_moraes_etal_IOC_2018.pdf.txtb3a7b734a6bfe5c29d1516814d63bfbeMD53icict/316362019-02-15 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dc.title.pt_BR.fl_str_mv Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
title Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
spellingShingle Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
Moraes, Isabel Matos Medeiros de
Ácido Oleico Omega-9
Azeite
Inflamação
Sepse Experimental
Omega-9 Oleic Acid
Olive Oil
Inflamamation
Experimental sepsis
title_short Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
title_full Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
title_fullStr Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
title_full_unstemmed Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
title_sort Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
author Moraes, Isabel Matos Medeiros de
author_facet Moraes, Isabel Matos Medeiros de
Albuquerque, Cassiano Felippe Gonçalves de
Kurz, Angela R .M.
Oliveira, Flora Magno de Jesus
Abreu, Victor Hugo Pereira de
Torres, Rafael Carvalho
Carvalho, Vinícius Frias
Estato, Vanessa
Bozza, Patrícia Torres
Sperandio, Markus
Faria Neto, Hugo Caire
Silva, Adriana Ribeiro
author_role author
author2 Albuquerque, Cassiano Felippe Gonçalves de
Kurz, Angela R .M.
Oliveira, Flora Magno de Jesus
Abreu, Victor Hugo Pereira de
Torres, Rafael Carvalho
Carvalho, Vinícius Frias
Estato, Vanessa
Bozza, Patrícia Torres
Sperandio, Markus
Faria Neto, Hugo Caire
Silva, Adriana Ribeiro
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moraes, Isabel Matos Medeiros de
Albuquerque, Cassiano Felippe Gonçalves de
Kurz, Angela R .M.
Oliveira, Flora Magno de Jesus
Abreu, Victor Hugo Pereira de
Torres, Rafael Carvalho
Carvalho, Vinícius Frias
Estato, Vanessa
Bozza, Patrícia Torres
Sperandio, Markus
Faria Neto, Hugo Caire
Silva, Adriana Ribeiro
dc.subject.other.pt_BR.fl_str_mv Ácido Oleico Omega-9
Azeite
Inflamação
Sepse Experimental
topic Ácido Oleico Omega-9
Azeite
Inflamação
Sepse Experimental
Omega-9 Oleic Acid
Olive Oil
Inflamamation
Experimental sepsis
dc.subject.en.pt_BR.fl_str_mv Omega-9 Oleic Acid
Olive Oil
Inflamamation
Experimental sepsis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-14T12:36:34Z
dc.date.available.fl_str_mv 2019-02-14T12:36:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORAES, Isabel Matos Medeiros de; et al. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 6053492, 13p, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31636
dc.identifier.issn.pt_BR.fl_str_mv 1942-0900
dc.identifier.doi.none.fl_str_mv 10.1155/2018/6053492
dc.identifier.eissn.none.fl_str_mv 1942-0994
identifier_str_mv MORAES, Isabel Matos Medeiros de; et al. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Medicine and Cellular Longevity, Volume 2018, Article ID 6053492, 13p, 2018.
1942-0900
10.1155/2018/6053492
1942-0994
url https://www.arca.fiocruz.br/handle/icict/31636
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/31636/2/isabelmatos_moraes_etal_IOC_2018.pdf
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