Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis

Detalhes bibliográficos
Autor(a) principal: Albuquerque, Cassiano Felippe Gonçalves de
Data de Publicação: 2016
Outros Autores: Moraes, Isabel Matos Medeiros de, Oliveira, Flora Magno de Jesus, Burth, Patrícia, Bozza, Patricia Torres, Faria, Mauro Velho Castro, Silva, Adriana Ribeiro, Faria Neto, Hugo Caire de Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14518
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Albuquerque, Cassiano Felippe Gonçalves deMoraes, Isabel Matos Medeiros deOliveira, Flora Magno de JesusBurth, PatríciaBozza, Patricia TorresFaria, Mauro Velho CastroSilva, Adriana RibeiroFaria Neto, Hugo Caire de Castro2016-06-19T22:20:25Z2016-07-08T12:22:05Z2016-06-19T22:20:25Z2016-07-08T12:22:05Z2016ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis. Plos One, v.11, n,4, e0153607, 18p, Apr. 20161932-6203https://www.arca.fiocruz.br/handle/icict/1451810.1371/journal. pone.0153607engPublic Library of ScienceSepseOmega-9Ácidos graxosDietaDiminuição da função orgãnicaSepsisOmega-9Fatty Acid OxidationDietsDecreases Organ DysfunctionOmega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Ciências Médicas. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Estácio de Sá. Programa de Produtividade Científica. Rio de Janeiro, RJ, Brasil .Sepsis is characterized by inflammatory and metabolic alterations, which lead to massive cytokine production, oxidative stress and organ dysfunction. In severe systemic inflammatory response syndrome, plasma non-esterified fatty acids (NEFA) are increased. Several NEFA are deleterious to cells, activate Toll-like receptors and inhibit Na+/K+-ATPase, causing lung injury. A Mediterranean diet rich in olive oil is beneficial. Themain component of olive oil is omega-9 oleic acid (OA), a monounsaturated fatty acid (MUFA).We analyzed the effect of OA supplementation on sepsis. OA ameliorated clinical symptoms, increased the survival rate, prevented liver and kidney injury and decreased NEFA plasma levels inmice subjected to cecal ligation and puncture (CLP). OA did not alter food intake and weight gain but diminished reactive oxygen species (ROS) production and NEFA plasma levels. Carnitine palmitoyltransferase IA (CPT1A) mRNA levels were increased, while uncoupling protein 2 (UCP2) liver expression was enhanced in mice treated with OA. OA also inhibited the decrease in 5' AMPactivated protein kinase (AMPK) expression and increased the enzyme expression in the liver of OA-treated mice compared to septic animals.We showed that OA pretreatment decreased NEFA concentration and increased CPT1A and UCP2 and AMPK levels, decreasing ROS production.We suggest that OA has a beneficial role in sepsis by decreasing metabolic dysfunction, supporting the benefits of diets high inmonounsaturated fatty acids (MUFA).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTflora_oliveira_etal_IOC_2016.PDF.txtflora_oliveira_etal_IOC_2016.PDF.txtExtracted 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dc.title.pt_BR.fl_str_mv Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
title Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
spellingShingle Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
Albuquerque, Cassiano Felippe Gonçalves de
Sepse
Omega-9
Ácidos graxos
Dieta
Diminuição da função orgãnica
Sepsis
Omega-9
Fatty Acid Oxidation
Diets
Decreases Organ Dysfunction
title_short Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
title_full Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
title_fullStr Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
title_full_unstemmed Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
title_sort Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis
author Albuquerque, Cassiano Felippe Gonçalves de
author_facet Albuquerque, Cassiano Felippe Gonçalves de
Moraes, Isabel Matos Medeiros de
Oliveira, Flora Magno de Jesus
Burth, Patrícia
Bozza, Patricia Torres
Faria, Mauro Velho Castro
Silva, Adriana Ribeiro
Faria Neto, Hugo Caire de Castro
author_role author
author2 Moraes, Isabel Matos Medeiros de
Oliveira, Flora Magno de Jesus
Burth, Patrícia
Bozza, Patricia Torres
Faria, Mauro Velho Castro
Silva, Adriana Ribeiro
Faria Neto, Hugo Caire de Castro
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Albuquerque, Cassiano Felippe Gonçalves de
Moraes, Isabel Matos Medeiros de
Oliveira, Flora Magno de Jesus
Burth, Patrícia
Bozza, Patricia Torres
Faria, Mauro Velho Castro
Silva, Adriana Ribeiro
Faria Neto, Hugo Caire de Castro
dc.subject.other.pt_BR.fl_str_mv Sepse
Omega-9
Ácidos graxos
Dieta
Diminuição da função orgãnica
topic Sepse
Omega-9
Ácidos graxos
Dieta
Diminuição da função orgãnica
Sepsis
Omega-9
Fatty Acid Oxidation
Diets
Decreases Organ Dysfunction
dc.subject.en.pt_BR.fl_str_mv Sepsis
Omega-9
Fatty Acid Oxidation
Diets
Decreases Organ Dysfunction
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-06-19T22:20:25Z
2016-07-08T12:22:05Z
dc.date.available.fl_str_mv 2016-06-19T22:20:25Z
2016-07-08T12:22:05Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis. Plos One, v.11, n,4, e0153607, 18p, Apr. 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14518
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal. pone.0153607
identifier_str_mv ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis. Plos One, v.11, n,4, e0153607, 18p, Apr. 2016
1932-6203
10.1371/journal. pone.0153607
url https://www.arca.fiocruz.br/handle/icict/14518
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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