Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/53123 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. |
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Godoy, Raquel Soares MaiaFelix, Luiza Dos SantosOrfanó, Alessandra da SilvaChaves, Bárbara AparecidaNogueira, Paula MonalisaCosta, Breno Dos AnjosSoares, Aline SilvaOliveira, Cinthia Catharina AzevedoPimenta, Rafael NacifSilva, Breno MelloDuarte, Ana PaulaLacerda, Marcus Vinicius Guimarães deMonteiro, Wuelton MarceloSecundino, Nágila Francinete CostaPimenta, Paulo Filemon Paolucci2022-06-08T17:19:54Z2022-06-08T17:19:54Z2021GODOY, Raquel Soares Maia et al. Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city. PLoS Negl Trop Dis., v. 15, n. 11, e0009839, 2021. doi: 10.1371/journal.pntd.0009839.1935-2735https://www.arca.fiocruz.br/handle/icict/5312310.1371/journal.pntd.0009839engPublic Library of ScienceDengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic cityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil./Universidade Federal de Minas Gerais Programa de Pós-Graduação em Biologia Celular. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais Programa de Pós-Graduação em Biologia Celular. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Departamento de Ciências Biológicas. Ouro Preto, MG, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, BrazilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais Programa de Pós-Graduação em Biologia Celular. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/ Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Dengue virus (DENV) and Zika virus (ZIKV) belong to the same viral family, the Flaviviridae. They cause recurring threats to the public health systems of tropical countries such as Brazil. The primary Brazilian vector of both viruses is the mosquito Aedes aegypti. After the mosquito ingests a blood meal from an infected person, the viruses infect and replicate in the midgut, disseminate to secondary tissues and reach the salivary gland (SG), where they are ready to be transmitted to a vertebrate host. It is thought that the intrinsic discrepancies among mosquitoes could affect their ability to deal with viral infections. This study confirms that the DENV and ZIKV infection patterns of nine Ae. aegypti field populations found in geographically separate health districts of an endemic Brazilian city vary. We analyzed the infection rate, disseminated infection, vector competence, and viral load through quantitative PCR. Mosquitoes were challenged using the membrane-feeding assay technique and were tested seven and fourteen days post-infection (early and late infection phases, respectively). The infection responses varied among the Ae. aegypti populations for both flaviviruses in the two infection phases. There was no similarity between DENV and ZIKV vector competencies or viral loads. According to the results of our study, the risk of viral transmission overtime after infection either increases or remains unaltered in ZIKV infected vectors. However, the risk may increase, decrease, or remain unaltered in DENV-infected vectors depending on the mosquito population. For both flaviviruses, the viral load persisted in the body even until the late infection phase. In contrast to DENV, the ZIKV accumulated in the SG over time in all the mosquito populations. These findings are novel and may help direct the development of control strategies to fight dengue and Zika outbreaks in endemic regions, and provide a warning about the importance of understanding mosquito responses to arboviral infectionsDengue virusZika virusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/53123/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city.pdfDengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic 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| dc.title.pt_BR.fl_str_mv |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| title |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| spellingShingle |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city Godoy, Raquel Soares Maia Dengue virus Zika virus |
| title_short |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| title_full |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| title_fullStr |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| title_full_unstemmed |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| title_sort |
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city |
| author |
Godoy, Raquel Soares Maia |
| author_facet |
Godoy, Raquel Soares Maia Felix, Luiza Dos Santos Orfanó, Alessandra da Silva Chaves, Bárbara Aparecida Nogueira, Paula Monalisa Costa, Breno Dos Anjos Soares, Aline Silva Oliveira, Cinthia Catharina Azevedo Pimenta, Rafael Nacif Silva, Breno Mello Duarte, Ana Paula Lacerda, Marcus Vinicius Guimarães de Monteiro, Wuelton Marcelo Secundino, Nágila Francinete Costa Pimenta, Paulo Filemon Paolucci |
| author_role |
author |
| author2 |
Felix, Luiza Dos Santos Orfanó, Alessandra da Silva Chaves, Bárbara Aparecida Nogueira, Paula Monalisa Costa, Breno Dos Anjos Soares, Aline Silva Oliveira, Cinthia Catharina Azevedo Pimenta, Rafael Nacif Silva, Breno Mello Duarte, Ana Paula Lacerda, Marcus Vinicius Guimarães de Monteiro, Wuelton Marcelo Secundino, Nágila Francinete Costa Pimenta, Paulo Filemon Paolucci |
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author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Godoy, Raquel Soares Maia Felix, Luiza Dos Santos Orfanó, Alessandra da Silva Chaves, Bárbara Aparecida Nogueira, Paula Monalisa Costa, Breno Dos Anjos Soares, Aline Silva Oliveira, Cinthia Catharina Azevedo Pimenta, Rafael Nacif Silva, Breno Mello Duarte, Ana Paula Lacerda, Marcus Vinicius Guimarães de Monteiro, Wuelton Marcelo Secundino, Nágila Francinete Costa Pimenta, Paulo Filemon Paolucci |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue virus Zika virus |
| topic |
Dengue virus Zika virus |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. |
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2021 |
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2021 |
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2022-06-08T17:19:54Z |
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2022-06-08T17:19:54Z |
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GODOY, Raquel Soares Maia et al. Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city. PLoS Negl Trop Dis., v. 15, n. 11, e0009839, 2021. doi: 10.1371/journal.pntd.0009839. |
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https://www.arca.fiocruz.br/handle/icict/53123 |
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1935-2735 |
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10.1371/journal.pntd.0009839 |
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GODOY, Raquel Soares Maia et al. Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city. PLoS Negl Trop Dis., v. 15, n. 11, e0009839, 2021. doi: 10.1371/journal.pntd.0009839. 1935-2735 10.1371/journal.pntd.0009839 |
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