Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels

Detalhes bibliográficos
Autor(a) principal: Carvalho, L. J. M.
Data de Publicação: 2004
Outros Autores: Oliveira, S. G., Theisen, M., Alves, F. A., Andrade, M. C. R., Zanini, G. M., Brígido, M. C. O., Oeuvray, C., Póvoa, M. M., Muniz, J. A. P. C., Druilhe, P., Daniel-Ribeiro, C. T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/j.0300-9475.2004.01409.x
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32988
Resumo: Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Carvalho, L. J. M.Oliveira, S. G.Theisen, M.Alves, F. A.Andrade, M. C. R.Zanini, G. M.Brígido, M. C. O.Oeuvray, C.Póvoa, M. M.Muniz, J. A. P. C.Druilhe, P.Daniel-Ribeiro, C. T.2019-05-08T12:45:18Z2019-05-08T12:45:18Z2004CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, 2004.0300-9475https://www.arca.fiocruz.br/handle/icict/3298810.1111/j.0300-9475.2004.01409.x1365-3083Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-05-08Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Belém, PA, Brasil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brasil.Statens Serum Institut. Clinical Biochemistr. Copenhagen, Denmark.National Primate Center. Belém, PA, Brazil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brazil.Fundação Oswaldo Cruz. Centro de Criação de Animais de Laboratório. Departamento de Primatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.National Primate Center. Belém, PA, Brazil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brazil.Institut Pasteur. Biomedical Parasitology. Paris, France.Instituto Evandro Chagas. Belém, PA, Brasil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brasil.National Primate Center. Belém, PA, Brazil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brazil.Institut Pasteur. Biomedical Parasitology. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S. sciureus monkeys immunized with MSP-3(212-380)-AS02 or GLURP(27-500)-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens.engWileyImmunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePlasmodium falciparumSaimiri sciureus monkeysImmunizationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
spellingShingle Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
Carvalho, L. J. M.
Plasmodium falciparum
Saimiri sciureus monkeys
Immunization
title_short Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_full Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_fullStr Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_full_unstemmed Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_sort Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
author Carvalho, L. J. M.
author_facet Carvalho, L. J. M.
Oliveira, S. G.
Theisen, M.
Alves, F. A.
Andrade, M. C. R.
Zanini, G. M.
Brígido, M. C. O.
Oeuvray, C.
Póvoa, M. M.
Muniz, J. A. P. C.
Druilhe, P.
Daniel-Ribeiro, C. T.
author_role author
author2 Oliveira, S. G.
Theisen, M.
Alves, F. A.
Andrade, M. C. R.
Zanini, G. M.
Brígido, M. C. O.
Oeuvray, C.
Póvoa, M. M.
Muniz, J. A. P. C.
Druilhe, P.
Daniel-Ribeiro, C. T.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, L. J. M.
Oliveira, S. G.
Theisen, M.
Alves, F. A.
Andrade, M. C. R.
Zanini, G. M.
Brígido, M. C. O.
Oeuvray, C.
Póvoa, M. M.
Muniz, J. A. P. C.
Druilhe, P.
Daniel-Ribeiro, C. T.
dc.subject.en.pt_BR.fl_str_mv Plasmodium falciparum
Saimiri sciureus monkeys
Immunization
topic Plasmodium falciparum
Saimiri sciureus monkeys
Immunization
description Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2019-05-08T12:45:18Z
dc.date.available.fl_str_mv 2019-05-08T12:45:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32988
dc.identifier.issn.pt_BR.fl_str_mv 0300-9475
dc.identifier.doi.none.fl_str_mv 10.1111/j.0300-9475.2004.01409.x
dc.identifier.eissn.none.fl_str_mv 1365-3083
identifier_str_mv CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, 2004.
0300-9475
10.1111/j.0300-9475.2004.01409.x
1365-3083
url https://www.arca.fiocruz.br/handle/icict/32988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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