Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
DOI: | 10.1111/j.0300-9475.2004.01409.x |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32988 |
Resumo: | Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Carvalho, L. J. M.Oliveira, S. G.Theisen, M.Alves, F. A.Andrade, M. C. R.Zanini, G. M.Brígido, M. C. O.Oeuvray, C.Póvoa, M. M.Muniz, J. A. P. C.Druilhe, P.Daniel-Ribeiro, C. T.2019-05-08T12:45:18Z2019-05-08T12:45:18Z2004CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, 2004.0300-9475https://www.arca.fiocruz.br/handle/icict/3298810.1111/j.0300-9475.2004.01409.x1365-3083Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-05-08Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Belém, PA, Brasil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brasil.Statens Serum Institut. Clinical Biochemistr. Copenhagen, Denmark.National Primate Center. Belém, PA, Brazil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brazil.Fundação Oswaldo Cruz. Centro de Criação de Animais de Laboratório. Departamento de Primatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.National Primate Center. Belém, PA, Brazil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brazil.Institut Pasteur. Biomedical Parasitology. Paris, France.Instituto Evandro Chagas. Belém, PA, Brasil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brasil.National Primate Center. Belém, PA, Brazil / Fundação Nacional de Saúde Superintendência Estadual do Pará. Belém, PA, Brazil.Institut Pasteur. Biomedical Parasitology. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S. sciureus monkeys immunized with MSP-3(212-380)-AS02 or GLURP(27-500)-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens.engWileyImmunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePlasmodium falciparumSaimiri sciureus monkeysImmunizationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
title |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
spellingShingle |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels Carvalho, L. J. M. Plasmodium falciparum Saimiri sciureus monkeys Immunization |
title_short |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
title_full |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
title_fullStr |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
title_full_unstemmed |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
title_sort |
Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels |
author |
Carvalho, L. J. M. |
author_facet |
Carvalho, L. J. M. Oliveira, S. G. Theisen, M. Alves, F. A. Andrade, M. C. R. Zanini, G. M. Brígido, M. C. O. Oeuvray, C. Póvoa, M. M. Muniz, J. A. P. C. Druilhe, P. Daniel-Ribeiro, C. T. |
author_role |
author |
author2 |
Oliveira, S. G. Theisen, M. Alves, F. A. Andrade, M. C. R. Zanini, G. M. Brígido, M. C. O. Oeuvray, C. Póvoa, M. M. Muniz, J. A. P. C. Druilhe, P. Daniel-Ribeiro, C. T. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, L. J. M. Oliveira, S. G. Theisen, M. Alves, F. A. Andrade, M. C. R. Zanini, G. M. Brígido, M. C. O. Oeuvray, C. Póvoa, M. M. Muniz, J. A. P. C. Druilhe, P. Daniel-Ribeiro, C. T. |
dc.subject.en.pt_BR.fl_str_mv |
Plasmodium falciparum Saimiri sciureus monkeys Immunization |
topic |
Plasmodium falciparum Saimiri sciureus monkeys Immunization |
description |
Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2019-05-08T12:45:18Z |
dc.date.available.fl_str_mv |
2019-05-08T12:45:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, 2004. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/32988 |
dc.identifier.issn.pt_BR.fl_str_mv |
0300-9475 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.0300-9475.2004.01409.x |
dc.identifier.eissn.none.fl_str_mv |
1365-3083 |
identifier_str_mv |
CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, 2004. 0300-9475 10.1111/j.0300-9475.2004.01409.x 1365-3083 |
url |
https://www.arca.fiocruz.br/handle/icict/32988 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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