Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection

Detalhes bibliográficos
Autor(a) principal: Oliveira, Joanna Reis Santos
Data de Publicação: 2012
Outros Autores: Cruz, Alda Maria da
Tipo de documento: Artigo
Idioma: spa
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18854
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
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spelling Oliveira, Joanna Reis SantosCruz, Alda Maria da2017-05-16T11:47:31Z2017-05-16T11:47:31Z2012OLIVEIRA, Joanna Reis Santos; CRUZ, Alda Maria da. Lipopolysaccharide-Induced Cellular ActivationMay Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. International Journal of Microbiology, Volume 2012, Article ID 364534, 4p, 2012.1687-918Xhttps://www.arca.fiocruz.br/handle/icict/1885410.1155/2012/3645341687-9198spaHindawi Publishing CorporationLeishmaniose visceralSaúde PúblicaAtivação Celular Induzida por LipopolissacarídeoImunopatogêneseCo-infecção pelo HIVVisceral Leishmaniasispublic healthneglected tropical diseasesImmunopathogenesisHIV CoinfectionLipopolysaccharide-Induced Cellular ActivationLipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil.Visceral Leishmaniasis (VL) is an infectious disease which constitutes a serious public health problem, integrating the list of neglected tropical diseases. The disease is characterized by a Leishmania-specific immune suppression T-cell depletion and a decrease of other hematopoietic cells. In parallel, an immunostimulatory response also occurs, represented by polyclonal B lymphocytes, T-cell activation, and systemic proinflammatory responses. Parasite antigens were believed to mediate both suppression and activation mechanisms, but these concepts are constantly being revised. Similar to reports on HIV/AIDS, we have proposed that gut parasitation by amastigotes and lymphocyte depletion could also affect gut-associated lymphoid tissue, leading to mucosal barrier breach and predisposing to microbial translocation. An increment of plasmatic lipopolysaccharide (LPS) levels observed in Brazilian VL patients was implicated in the reduced blood CD4(+) and CD8(+) T cell counts, systemic T-cell activation, pro-inflammatory cytokines and MIF plasma levels, suggesting that a bacterial molecule not associated with Leishmania infection can exert deleterious effects on immune system. Recent results also pointed that the proinflammatory response was potentiated in VL/HIV-AIDS coinfected patients. The LPS-mediated cell activation adds another concept to the immunopathogenesis of VL and can bring a rational for new therapeutic interventions that could ameliorate the management of these patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18854/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjoana_oliveira_etal_IOC_2012.pdfjoana_oliveira_etal_IOC_2012.pdfapplication/pdf1103413https://www.arca.fiocruz.br/bitstream/icict/18854/2/joana_oliveira_etal_IOC_2012.pdf8a9133a18f2fcf85fa62dda46fb74527MD52TEXTjoana_oliveira_etal_IOC_2012.pdf.txtjoana_oliveira_etal_IOC_2012.pdf.txtExtracted texttext/plain22277https://www.arca.fiocruz.br/bitstream/icict/18854/3/joana_oliveira_etal_IOC_2012.pdf.txte2fff63ad25584bbd92ea17a239cc085MD53icict/188542018-08-15 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dc.title.pt_BR.fl_str_mv Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
title Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
spellingShingle Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
Oliveira, Joanna Reis Santos
Leishmaniose visceral
Saúde Pública
Ativação Celular Induzida por Lipopolissacarídeo
Imunopatogênese
Co-infecção pelo HIV
Visceral Leishmaniasis
public health
neglected tropical diseases
Immunopathogenesis
HIV Coinfection
Lipopolysaccharide-Induced Cellular Activation
title_short Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
title_full Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
title_fullStr Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
title_full_unstemmed Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
title_sort Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection
author Oliveira, Joanna Reis Santos
author_facet Oliveira, Joanna Reis Santos
Cruz, Alda Maria da
author_role author
author2 Cruz, Alda Maria da
author2_role author
dc.contributor.author.fl_str_mv Oliveira, Joanna Reis Santos
Cruz, Alda Maria da
dc.subject.other.pt_BR.fl_str_mv Leishmaniose visceral
Saúde Pública
Ativação Celular Induzida por Lipopolissacarídeo
Imunopatogênese
Co-infecção pelo HIV
topic Leishmaniose visceral
Saúde Pública
Ativação Celular Induzida por Lipopolissacarídeo
Imunopatogênese
Co-infecção pelo HIV
Visceral Leishmaniasis
public health
neglected tropical diseases
Immunopathogenesis
HIV Coinfection
Lipopolysaccharide-Induced Cellular Activation
dc.subject.en.pt_BR.fl_str_mv Visceral Leishmaniasis
public health
neglected tropical diseases
Immunopathogenesis
HIV Coinfection
Lipopolysaccharide-Induced Cellular Activation
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-05-16T11:47:31Z
dc.date.available.fl_str_mv 2017-05-16T11:47:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Joanna Reis Santos; CRUZ, Alda Maria da. Lipopolysaccharide-Induced Cellular ActivationMay Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. International Journal of Microbiology, Volume 2012, Article ID 364534, 4p, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18854
dc.identifier.issn.pt_BR.fl_str_mv 1687-918X
dc.identifier.doi.none.fl_str_mv 10.1155/2012/364534
dc.identifier.eissn.none.fl_str_mv 1687-9198
identifier_str_mv OLIVEIRA, Joanna Reis Santos; CRUZ, Alda Maria da. Lipopolysaccharide-Induced Cellular ActivationMay Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. International Journal of Microbiology, Volume 2012, Article ID 364534, 4p, 2012.
1687-918X
10.1155/2012/364534
1687-9198
url https://www.arca.fiocruz.br/handle/icict/18854
dc.language.iso.fl_str_mv spa
language spa
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/18854/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/18854/2/joana_oliveira_etal_IOC_2012.pdf
https://www.arca.fiocruz.br/bitstream/icict/18854/3/joana_oliveira_etal_IOC_2012.pdf.txt
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