Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study

Detalhes bibliográficos
Autor(a) principal: Carmo, Thomas A
Data de Publicação: 2022
Outros Autores: Ferreira, Isabella B B, Menezes, Rodrigo C, Pina, Márcio L T, Oliveira, Roberto S, Telles, Gabriel P, Machado, Antônio F A, Aguiar, Tércio C, Caldas, Juliana R, Arriaga, María B, Akrami, Kevan M, Filgueiras Filho, Nivaldo M, Andrade, Bruno B
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54856
Resumo: Intramural Research Programa da Fundação Oswaldo Cruz, Brasil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fogarty International Center and National Institute of Child Health and Human Development of the National Institutes of Health. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
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spelling Carmo, Thomas AFerreira, Isabella B BMenezes, Rodrigo CPina, Márcio L TOliveira, Roberto STelles, Gabriel PMachado, Antônio F AAguiar, Tércio CCaldas, Juliana RArriaga, María BAkrami, Kevan MFilgueiras Filho, Nivaldo MAndrade, Bruno B2022-09-23T17:44:41Z2022-09-23T17:44:41Z2022CARMO, Thomas A. et al. Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study. Frontiers in Medicine, n. 9, p. 1-8, 2022.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/5485610.3389/fmed.2022.958291Intramural Research Programa da Fundação Oswaldo Cruz, Brasil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fogarty International Center and National Institute of Child Health and Human Development of the National Institutes of Health. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Universidade Salvador. Salvador, BA, Brasil / Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Faculdade de Medicina da Bahia, Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Salvador. Salvador, BA, Brasil.Universidade Salvador. Salvador, BA, Brasil.Hospital São Rafael. Rede Dor. Salvador, BA, Brasil.Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica. Salvador, BA, Brasil / Faculdade de Medicina da Bahia, Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica. Salvador, BA, Brasil / Faculdade de Medicina da Bahia, Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / University of California. Department of Medicine. Divisions of Infectious Diseases and Pulmonary, Critical Care and Sleep Medicine. San Diego, CA, United States.Universidade Salvador. Salvador, BA, Brasil / Hospital de Cidade. Núcleo de Pesquisa, Ensino e Comunicação. Salvador, BA, Brasil.Universidade Salvador. Salvador, BA, Brasil / Rede de Organizações Multinacionais Patrocinando Iniciativa de Pesquisa Translacional e Epidemiológica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Background: Prognostic tools developed to stratify critically ill patients in Intensive Care Units (ICUs), are critical to predict those with higher risk of mortality in the first hours of admission. This study aims to evaluate the performance of the pShock score in critically ill patients admitted to the ICU with SARS-CoV-2 infection. Methods: Prospective observational analytical cohort study conducted between January 2020 and March 2021 in four general ICUs in Salvador, Brazil. Descriptive statistics were used to characterize the cohort and a logistic regression, followed by cross-validation, were performed to calibrate the score. A ROC curve analysis was used to assess accuracy of the models analyzed. Results: Six hundred five adult ICU patients were included in the study. The median age was 63 (IQR: 49-74) years with a mortality rate of 33.2% (201 patients). The calibrated pShock-CoV score performed well in prediction of ICU mortality (AUC of 0.80 [95% Confidence Interval (CI): 0.77-0.83; p-value < 0.0001]). Conclusions: The pShock-CoV score demonstrated robust discriminatory capacity and may assist in targeting scarce ICU resources during the COVID-19 pandemic to those critically ill patients most likely to benefit.engFrontiers MediaCritical CarePrognosisCOVID-19MortalityRisk factorsCuidados intensivosPrognósticoCOVID-19Fatores de riscoMortalidadeFatores de riscoCritical carePrognosisCOVID-19MortalityRisk factorsCuidados CríticosPrognósticoCOVID-19MortalidadeFatores de RiscoCalibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54856/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarmo, Thomas A - Calibration and validation of the.pdfCarmo, Thomas A - Calibration and validation of the.pdfapplication/pdf3826463https://www.arca.fiocruz.br/bitstream/icict/54856/2/Carmo%2c%20Thomas%20%20A%20-%20Calibration%20and%20validation%20of%20the.pdfcaef357b6925776eeeea4ac2c019071cMD52icict/548562023-03-15 14:32:52.182oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:52Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
spellingShingle Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
Carmo, Thomas A
Critical Care
Prognosis
COVID-19
Mortality
Risk factors
Cuidados intensivos
Prognóstico
COVID-19
Fatores de risco
Mortalidade
Fatores de risco
Critical care
Prognosis
COVID-19
Mortality
Risk factors
Cuidados Críticos
Prognóstico
COVID-19
Mortalidade
Fatores de Risco
title_short Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_full Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_fullStr Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_full_unstemmed Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
title_sort Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
author Carmo, Thomas A
author_facet Carmo, Thomas A
Ferreira, Isabella B B
Menezes, Rodrigo C
Pina, Márcio L T
Oliveira, Roberto S
Telles, Gabriel P
Machado, Antônio F A
Aguiar, Tércio C
Caldas, Juliana R
Arriaga, María B
Akrami, Kevan M
Filgueiras Filho, Nivaldo M
Andrade, Bruno B
author_role author
author2 Ferreira, Isabella B B
Menezes, Rodrigo C
Pina, Márcio L T
Oliveira, Roberto S
Telles, Gabriel P
Machado, Antônio F A
Aguiar, Tércio C
Caldas, Juliana R
Arriaga, María B
Akrami, Kevan M
Filgueiras Filho, Nivaldo M
Andrade, Bruno B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carmo, Thomas A
Ferreira, Isabella B B
Menezes, Rodrigo C
Pina, Márcio L T
Oliveira, Roberto S
Telles, Gabriel P
Machado, Antônio F A
Aguiar, Tércio C
Caldas, Juliana R
Arriaga, María B
Akrami, Kevan M
Filgueiras Filho, Nivaldo M
Andrade, Bruno B
dc.subject.mesh.en_US.fl_str_mv Critical Care
Prognosis
COVID-19
Mortality
Risk factors
topic Critical Care
Prognosis
COVID-19
Mortality
Risk factors
Cuidados intensivos
Prognóstico
COVID-19
Fatores de risco
Mortalidade
Fatores de risco
Critical care
Prognosis
COVID-19
Mortality
Risk factors
Cuidados Críticos
Prognóstico
COVID-19
Mortalidade
Fatores de Risco
dc.subject.other.en_US.fl_str_mv Cuidados intensivos
Prognóstico
COVID-19
Fatores de risco
Mortalidade
Fatores de risco
dc.subject.en.en_US.fl_str_mv Critical care
Prognosis
COVID-19
Mortality
Risk factors
dc.subject.decs.en_US.fl_str_mv Cuidados Críticos
Prognóstico
COVID-19
Mortalidade
Fatores de Risco
description Intramural Research Programa da Fundação Oswaldo Cruz, Brasil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fogarty International Center and National Institute of Child Health and Human Development of the National Institutes of Health. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-23T17:44:41Z
dc.date.available.fl_str_mv 2022-09-23T17:44:41Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARMO, Thomas A. et al. Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study. Frontiers in Medicine, n. 9, p. 1-8, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54856
dc.identifier.issn.en_US.fl_str_mv 2296-858X
dc.identifier.doi.none.fl_str_mv 10.3389/fmed.2022.958291
identifier_str_mv CARMO, Thomas A. et al. Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study. Frontiers in Medicine, n. 9, p. 1-8, 2022.
2296-858X
10.3389/fmed.2022.958291
url https://www.arca.fiocruz.br/handle/icict/54856
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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