Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.

Detalhes bibliográficos
Autor(a) principal: Hirako, Isabella Cristina
Data de Publicação: 2016
Outros Autores: Silva, Marco Antônio Ataíde, Faustino, Lucas, Assis, Patricia Aparecida de, Sorensen, Elizabeth W., Ueta, Hisashi, Araujo, Natalia Martinez de, Menezes, Gustavo Batista, Luster, Andrew D, Gazzinelli, Ricardo Tostes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18350
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Harvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USA
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spelling Hirako, Isabella CristinaSilva, Marco Antônio AtaídeFaustino, LucasAssis, Patricia Aparecida deSorensen, Elizabeth W.Ueta, HisashiAraujo, Natalia Martinez deMenezes, Gustavo BatistaLuster, Andrew DGazzinelli, Ricardo Tostes2017-04-10T18:54:24Z2017-04-10T18:54:24Z2016HIRAKO, Isabella Cristina et al. Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria. Nature Communications 7, Art. 13277, 20162041-1723https://www.arca.fiocruz.br/handle/icict/1835010.1038/ncomms13277engNatureresposta antimicrobianaAntimicrobial responsesParasite host responseSplenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Harvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Morfologia. Departamento de Bioquímica e Imunologia e Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilHarvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilHarvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USAHarvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Morfologia. Departamento de Bioquímica e Imunologia e Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Morfologia. Departamento de Bioquímica e Imunologia e Centro de Biologia Gastrointestinal. Belo Horizonte, MG, BrazilHarvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Morfologia. Departamento de Bioquímica e Imunologia e Centro de Biologia Gastrointestinal. Belo Horizonte, MG, Brazil/ Harvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USADendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5+CXCL9/10+ MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8+ T lymphocytes, leading to a lethal neuropathological syndrome.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/18350/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Hirako_Isabella_Splenic differentiation_CPqRR_2016.pdfve_Hirako_Isabella_Splenic differentiation_CPqRR_2016.pdfapplication/pdf3951445https://www.arca.fiocruz.br/bitstream/icict/18350/2/ve_Hirako_Isabella_Splenic%20differentiation_CPqRR_2016.pdf7b68a99da4fad0b8cef0052c57724ddeMD52TEXTve_Hirako_Isabella_Splenic differentiation_CPqRR_2016.pdf.txtve_Hirako_Isabella_Splenic differentiation_CPqRR_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
title Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
spellingShingle Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
Hirako, Isabella Cristina
resposta antimicrobiana
Antimicrobial responses
Parasite host response
title_short Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
title_full Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
title_fullStr Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
title_full_unstemmed Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
title_sort Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria.
author Hirako, Isabella Cristina
author_facet Hirako, Isabella Cristina
Silva, Marco Antônio Ataíde
Faustino, Lucas
Assis, Patricia Aparecida de
Sorensen, Elizabeth W.
Ueta, Hisashi
Araujo, Natalia Martinez de
Menezes, Gustavo Batista
Luster, Andrew D
Gazzinelli, Ricardo Tostes
author_role author
author2 Silva, Marco Antônio Ataíde
Faustino, Lucas
Assis, Patricia Aparecida de
Sorensen, Elizabeth W.
Ueta, Hisashi
Araujo, Natalia Martinez de
Menezes, Gustavo Batista
Luster, Andrew D
Gazzinelli, Ricardo Tostes
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hirako, Isabella Cristina
Silva, Marco Antônio Ataíde
Faustino, Lucas
Assis, Patricia Aparecida de
Sorensen, Elizabeth W.
Ueta, Hisashi
Araujo, Natalia Martinez de
Menezes, Gustavo Batista
Luster, Andrew D
Gazzinelli, Ricardo Tostes
dc.subject.other.pt_BR.fl_str_mv resposta antimicrobiana
topic resposta antimicrobiana
Antimicrobial responses
Parasite host response
dc.subject.en.pt_BR.fl_str_mv Antimicrobial responses
Parasite host response
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Harvard Medical School. Massachusetts General Hospital. Division of Rheumatology, Allergy and Immunology. Charlestown, MA, USA
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-04-10T18:54:24Z
dc.date.available.fl_str_mv 2017-04-10T18:54:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HIRAKO, Isabella Cristina et al. Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria. Nature Communications 7, Art. 13277, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18350
dc.identifier.issn.pt_BR.fl_str_mv 2041-1723
dc.identifier.doi.none.fl_str_mv 10.1038/ncomms13277
identifier_str_mv HIRAKO, Isabella Cristina et al. Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria. Nature Communications 7, Art. 13277, 2016
2041-1723
10.1038/ncomms13277
url https://www.arca.fiocruz.br/handle/icict/18350
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/18350/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/18350/2/ve_Hirako_Isabella_Splenic%20differentiation_CPqRR_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/18350/3/ve_Hirako_Isabella_Splenic%20differentiation_CPqRR_2016.pdf.txt
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