Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.

Detalhes bibliográficos
Autor(a) principal: Titus, Richard G
Data de Publicação: 2001
Outros Autores: Dekrey, Gregory K, Morris, Robin V, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9911
Resumo: College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
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spelling Titus, Richard GDekrey, Gregory KMorris, Robin VSoares, Milena Botelho Pereira2015-04-07T17:24:36Z2015-04-07T17:24:36Z2001TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.0104-5695https://www.arca.fiocruz.br/handle/icict/991110.1128/IAI.69.8.5189–5192.2001engAmerican Society for MicrobiologyInterleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCollege of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USACollege of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USACollege of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSince interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.Citocinas/genéticaRegulação da Expressão GênicaInterleucina-6/imunologiaLeishmania major/imunologiaLeishmaniose Cutânea/imunologiaAnimaisSuscetibilidade a Doenças/imunologiaRegulação para BaixoInterleucina-6/genéticaLeishmaniose Cutânea/genéticaLeishmaniose Cutânea/fisiopatologiaCamundongosCamundongos Endogâmicos BALB CCamundongos KnockoutCélulas Th1/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9911/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALTitus RG Interleukin-6 Deficiency influences.......pdfTitus RG Interleukin-6 Deficiency influences.......pdfapplication/pdf71902https://www.arca.fiocruz.br/bitstream/icict/9911/2/Titus%20RG%20Interleukin-6%20Deficiency%20influences.......pdfcf45120ee1593ce25a60168fb6405960MD52TEXTTitus RG Interleukin-6 Deficiency influences.......pdf.txtTitus RG Interleukin-6 Deficiency influences.......pdf.txtExtracted texttext/plain18399https://www.arca.fiocruz.br/bitstream/icict/9911/3/Titus%20RG%20Interleukin-6%20Deficiency%20influences.......pdf.txtec70c383a11fcdb3946e1bcfeba9c091MD53icict/99112023-03-15 14:33:09.149oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
title Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
spellingShingle Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
Titus, Richard G
Citocinas/genética
Regulação da Expressão Gênica
Interleucina-6/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Suscetibilidade a Doenças/imunologia
Regulação para Baixo
Interleucina-6/genética
Leishmaniose Cutânea/genética
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Células Th1/imunologia
title_short Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
title_full Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
title_fullStr Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
title_full_unstemmed Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
title_sort Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.
author Titus, Richard G
author_facet Titus, Richard G
Dekrey, Gregory K
Morris, Robin V
Soares, Milena Botelho Pereira
author_role author
author2 Dekrey, Gregory K
Morris, Robin V
Soares, Milena Botelho Pereira
author2_role author
author
author
dc.contributor.author.fl_str_mv Titus, Richard G
Dekrey, Gregory K
Morris, Robin V
Soares, Milena Botelho Pereira
dc.subject.decs.pt_BR.fl_str_mv Citocinas/genética
Regulação da Expressão Gênica
Interleucina-6/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Suscetibilidade a Doenças/imunologia
Regulação para Baixo
Interleucina-6/genética
Leishmaniose Cutânea/genética
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Células Th1/imunologia
topic Citocinas/genética
Regulação da Expressão Gênica
Interleucina-6/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Suscetibilidade a Doenças/imunologia
Regulação para Baixo
Interleucina-6/genética
Leishmaniose Cutânea/genética
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Células Th1/imunologia
description College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2015-04-07T17:24:36Z
dc.date.available.fl_str_mv 2015-04-07T17:24:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9911
dc.identifier.issn.none.fl_str_mv 0104-5695
dc.identifier.doi.none.fl_str_mv 10.1128/IAI.69.8.5189–5192.2001
identifier_str_mv TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.
0104-5695
10.1128/IAI.69.8.5189–5192.2001
url https://www.arca.fiocruz.br/handle/icict/9911
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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