Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints

Detalhes bibliográficos
Autor(a) principal: Shigunov, Patrícia
Data de Publicação: 2014
Outros Autores: Dallagiovanna, Bruno, Holetz, Fabíola Barbieri
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16103
Resumo: Ministério da Saúde, Fundação Araucária, FIOCRUZ
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spelling Shigunov, PatríciaDallagiovanna, BrunoHoletz, Fabíola Barbieri2016-10-05T18:22:43Z2016-10-05T18:22:43Z2014SHIGUNOV, Patrícia; DALLAGIOVANNA, Bruno; HOLETZ, Fabíola. Stem Cells and the translational control of differentiation: following the ribosome footprints. J Mol. Genet. Med., v.8, n.111, p. 1-5, 2014.1747-0862https://www.arca.fiocruz.br/handle/icict/1610310.4172/1747-0862.1000111Ministério da Saúde, Fundação Araucária, FIOCRUZFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Stem cells have been proposed as a promising source for cell therapy. Understanding the biological processes that commit stem cells to differentiate into a particular cell type is essential for the successful repair of injured tissue, and even for whole organogenesis. Cellular differentiation can be modeled as a network of regulatory circuits that direct various steps of gene expression and mediate the spatiotemporal control of a cell’s proteome. In this minireview, we discuss the current aspects of posttranscriptional regulation of gene expression in stem cells, with an emphasis on translational regulation. Several data supports the idea that a significant percentage of genes have their expression controlled at the translational level during stem cell commitment and differentiation. We focus on strategies using polysome and ribosome profiling to measure translational rates and to unravel the dynamics of this process.engSusumu MinamisawaStem Cells and the Translational Control of Differentiation: Following the Ribosome Footprintsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleStem cellsTranslationDifferentiationPolysome profilingRibosome profilingCélulas-TroncoBiossíntese de ProteínasDiferenciação CelularPolirribossomosRibossomosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/16103/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALStem Cells and the Translational Control of Differentiation.pdfStem Cells and the Translational Control of 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dc.title.pt_BR.fl_str_mv Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
title Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
spellingShingle Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
Shigunov, Patrícia
Stem cells
Translation
Differentiation
Polysome profiling
Ribosome profiling
Células-Tronco
Biossíntese de Proteínas
Diferenciação Celular
Polirribossomos
Ribossomos
title_short Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
title_full Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
title_fullStr Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
title_full_unstemmed Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
title_sort Stem Cells and the Translational Control of Differentiation: Following the Ribosome Footprints
author Shigunov, Patrícia
author_facet Shigunov, Patrícia
Dallagiovanna, Bruno
Holetz, Fabíola Barbieri
author_role author
author2 Dallagiovanna, Bruno
Holetz, Fabíola Barbieri
author2_role author
author
dc.contributor.author.fl_str_mv Shigunov, Patrícia
Dallagiovanna, Bruno
Holetz, Fabíola Barbieri
dc.subject.en.pt_BR.fl_str_mv Stem cells
Translation
Differentiation
Polysome profiling
Ribosome profiling
topic Stem cells
Translation
Differentiation
Polysome profiling
Ribosome profiling
Células-Tronco
Biossíntese de Proteínas
Diferenciação Celular
Polirribossomos
Ribossomos
dc.subject.decs.pt_BR.fl_str_mv Células-Tronco
Biossíntese de Proteínas
Diferenciação Celular
Polirribossomos
Ribossomos
description Ministério da Saúde, Fundação Araucária, FIOCRUZ
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2016-10-05T18:22:43Z
dc.date.available.fl_str_mv 2016-10-05T18:22:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SHIGUNOV, Patrícia; DALLAGIOVANNA, Bruno; HOLETZ, Fabíola. Stem Cells and the translational control of differentiation: following the ribosome footprints. J Mol. Genet. Med., v.8, n.111, p. 1-5, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16103
dc.identifier.issn.pt_BR.fl_str_mv 1747-0862
dc.identifier.doi.pt_BR.fl_str_mv 10.4172/1747-0862.1000111
identifier_str_mv SHIGUNOV, Patrícia; DALLAGIOVANNA, Bruno; HOLETZ, Fabíola. Stem Cells and the translational control of differentiation: following the ribosome footprints. J Mol. Genet. Med., v.8, n.111, p. 1-5, 2014.
1747-0862
10.4172/1747-0862.1000111
url https://www.arca.fiocruz.br/handle/icict/16103
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Susumu Minamisawa
publisher.none.fl_str_mv Susumu Minamisawa
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16103/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/16103/3/Stem%20Cells%20and%20the%20Translational%20Control%20of%20Differentiation.pdf.txt
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