Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56404 |
Resumo: | Fundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil. |
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Oliveira, Gabriella S.Silva‐Flannery, LucianaSilva, Juliana F.Siza, CharleneEsteves, Roberto J.Marston, Barbara J.Morgan, JuliettePlucinski, MateuszRoca, Tárcio P.Silva, Ana M. P.Pereira, Soraya S.Salcedo, Juan M. V.Pereira, Dhelio B.Naveca, Felipe G.Dall'Acqua, Deusilene S. VieiraBrazil Investigation Team2023-01-09T17:54:28Z2023-01-09T17:54:28Z2022OLIVEIRA, Gabriella S. et al. Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon. Journal of Medical Virology, v. 94, p. 3410-3415, Feb. 2022.1096-9071https://www.arca.fiocruz.br/handle/icict/5640410.1002/jmv.27686engWileySARS‐CoV‐2Amazônia BrasileiraVigilância ativaMu varianteActive surveillanceBrazilian AmazonMu variantSARS‐CoV‐2Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil.COVID‐19 Response ‐ Internation Task Force, Centers for Diseases Control and Prevention (CDC). Atlanta, Georgia, USA.COVID‐19 Response ‐ Internation Task Force, Centers for Diseases Control and Prevention (CDC). Atlanta, Georgia, USA.COVID‐19 Response ‐ Internation Task Force, Centers for Diseases Control and Prevention (CDC). Atlanta, Georgia, USA.South America Regional Office, Centers for Diseases Control and Prevention (CDC). Brasília, DF, Brasil.COVID‐19 Response ‐ Internation Task Force, Centers for Diseases Control and Prevention (CDC). Atlanta, Georgia, USA.South America Regional Office, Centers for Diseases Control and Prevention (CDC). Brasília, DF, Brasil.COVID‐19 Response ‐ Internation Task Force, Centers for Diseases Control and Prevention (CDC). Atlanta, Georgia, USA.Fundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil.Fundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil.Fundação Oswaldo Cruz. Laboratório de Engenharia de Anticorpos. Rondônia, Brasil.Fundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil / CEPEM. Centro de Pesquisa em Medicina Tropical. Porto Velho, Rondônia, Brasil.CEPEM. Centro de Pesquisa em Medicina Tropical. Porto Velho, Rondônia, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil / Fundação Oswaldo Cruz. Laboratório de Engenharia de Anticorpos. Rondônia, Brasil.Through active surveillance and contact tracing from outpatients, we aimed to identify and characterize SARS‐CoV‐2 variants circulating in Porto Velho‐Rondônia, a city in the Brazilian Amazon. As part of a prospective cohort, we gathered information from 2,506 individuals among COVID‐19 patients and household contacts. Epidemiological data, nasopharyngeal swabs, and blood samples were collected from all participants. Nasopharyngeal swabs were tested for antigen rapid diagnostic test and reverse transcription‐polymerase chain reaction (RT‐PCR) followed by genomic sequencing. Blood samples underwent ELISA testing for IgA, IgG, and IgM antibody levels. From 757 specimens sequenced, three were identified as Mu variant, none of the individuals carrying this variant had a travel history in the previous 15 days before diagnosis. One case was asymptomatic and two presented mild symptoms. Two infected individuals from different households caring viruses with additional amino acid substitutions ORF7a P45L and ORF1a T1055A compared to the Mu virus reference sequence. One patient presented IgG levels. Our results highlight that genomic surveillance for SARS‐CoV‐2 variants can assist in detecting the emergency of SARS‐CoV‐2 variants in the community, before its identification in other parts of the country.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56404/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGabriellaOliveira_TarcioRoca_etal_IOC_2022.pdfGabriellaOliveira_TarcioRoca_etal_IOC_2022.pdfapplication/pdf969178https://www.arca.fiocruz.br/bitstream/icict/56404/2/GabriellaOliveira_TarcioRoca_etal_IOC_2022.pdf7b72ebe47a3c6b8798809a1f206119edMD52icict/564042023-09-04 11:10:49.174oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:10:49Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.en_US.fl_str_mv |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| title |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| spellingShingle |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon Oliveira, Gabriella S. SARS‐CoV‐2 Amazônia Brasileira Vigilância ativa Mu variante Active surveillance Brazilian Amazon Mu variant SARS‐CoV‐2 |
| title_short |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| title_full |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| title_fullStr |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| title_full_unstemmed |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| title_sort |
Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon |
| author |
Oliveira, Gabriella S. |
| author_facet |
Oliveira, Gabriella S. Silva‐Flannery, Luciana Silva, Juliana F. Siza, Charlene Esteves, Roberto J. Marston, Barbara J. Morgan, Juliette Plucinski, Mateusz Roca, Tárcio P. Silva, Ana M. P. Pereira, Soraya S. Salcedo, Juan M. V. Pereira, Dhelio B. Naveca, Felipe G. Dall'Acqua, Deusilene S. Vieira Brazil Investigation Team |
| author_role |
author |
| author2 |
Silva‐Flannery, Luciana Silva, Juliana F. Siza, Charlene Esteves, Roberto J. Marston, Barbara J. Morgan, Juliette Plucinski, Mateusz Roca, Tárcio P. Silva, Ana M. P. Pereira, Soraya S. Salcedo, Juan M. V. Pereira, Dhelio B. Naveca, Felipe G. Dall'Acqua, Deusilene S. Vieira Brazil Investigation Team |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Gabriella S. Silva‐Flannery, Luciana Silva, Juliana F. Siza, Charlene Esteves, Roberto J. Marston, Barbara J. Morgan, Juliette Plucinski, Mateusz Roca, Tárcio P. Silva, Ana M. P. Pereira, Soraya S. Salcedo, Juan M. V. Pereira, Dhelio B. Naveca, Felipe G. Dall'Acqua, Deusilene S. Vieira Brazil Investigation Team |
| dc.subject.other.en_US.fl_str_mv |
SARS‐CoV‐2 Amazônia Brasileira Vigilância ativa Mu variante |
| topic |
SARS‐CoV‐2 Amazônia Brasileira Vigilância ativa Mu variante Active surveillance Brazilian Amazon Mu variant SARS‐CoV‐2 |
| dc.subject.en.en_US.fl_str_mv |
Active surveillance Brazilian Amazon Mu variant SARS‐CoV‐2 |
| description |
Fundação Oswaldo Cruz. Laboratório de Virologia Molecular. Rondônia, Brasil. |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-01-09T17:54:28Z |
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2023-01-09T17:54:28Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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OLIVEIRA, Gabriella S. et al. Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon. Journal of Medical Virology, v. 94, p. 3410-3415, Feb. 2022. |
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https://www.arca.fiocruz.br/handle/icict/56404 |
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1096-9071 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/jmv.27686 |
| identifier_str_mv |
OLIVEIRA, Gabriella S. et al. Active surveillance and early detection of community transmission of SARS‐CoV‐2Mu variant (B.1.621) in the Brazilian Amazon. Journal of Medical Virology, v. 94, p. 3410-3415, Feb. 2022. 1096-9071 10.1002/jmv.27686 |
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https://www.arca.fiocruz.br/handle/icict/56404 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Wiley |
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Wiley |
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