Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.

Detalhes bibliográficos
Autor(a) principal: Vidal, Maura R. F. S
Data de Publicação: 1993
Outros Autores: Barbosa Junior, Aryon de Almeida, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5744
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Vidal, Maura R. F. SBarbosa Junior, Aryon de AlmeidaAndrade, Zilton de Araújo2012-10-30T20:32:24Z2012-10-30T20:32:24Z1993VIDAL, M. R. S.; BARBOSA JÚNIOR, A. A.; ANDRADE, Z. A. Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas. Revista do Instituto de Medicina Tropical de São Paulo, v. 35, n. 5, p. 423-9, sep.-oct. 1993.0036-4665https://www.arca.fiocruz.br/handle/icict/5744engExperimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNumerous pulmonary schistosome egg granulomas were present in mice submitted to partial portal vein ligation (Warren's model). The granulomas were characterized by cellular aggregations formed within alveolar tissue. Main cellular types were macrophages (epithelioid cells), eosinophils, plasma cells and lymphocytes. These cells were supported by scanty fibrous stroma and exhibited close membrane contact points amongst themselves, but without forming specialized adhesion apparatus. When granulomas involved arterial structures, proliferation of endothelial and smooth muscle cells occurred and fibrosis associated with angiogenesis became more evident. Granulomas formed around mature eggs in the pulmonary alveolar tissue presented approximately the same size and morphology regardless of the time of infection, the latter being 10, 18 and 25 weeks after cercarial exposure. This persistence of morphological appearance suggests that pulmonary granulomas do not undergo immunological modulation, as is the case with the granulomas in the liver and, to a lesser extent, in the intestines. Probably, besides general immunological factors, local (stromal) factors play an important role in schistosomal granuloma modulation.Experimental schistosomiasisPulmonary schistosomiasisPeriovular granulomaImmunological modulationGranuloma/patologiaPneumopatias Parasitárias/patologiaEsquistossomose/patologiaAnimaisGranuloma/parasitologiaPulmão/parasitologiaPulmão/ultraestruturaMasculinoCamundongosÓvulo/parasitologiaVeia Porta/cirurgiaFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVidal MRFS Experimental pulmonary....pdfVidal MRFS Experimental pulmonary....pdfapplication/pdf905950https://www.arca.fiocruz.br/bitstream/icict/5744/1/Vidal%20MRFS%20Experimental%20pulmonary....pdfc4d4997ba5dd01dfdc3dd8aea6950bb6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5744/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTVidal MRFS Experimental pulmonary....pdf.txtVidal MRFS Experimental pulmonary....pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/5744/5/Vidal%20MRFS%20Experimental%20pulmonary....pdf.txt212b0306580d4f0044d18f9a3edcc832MD55THUMBNAILVidal MRFS Experimental pulmonary....pdf.jpgVidal MRFS Experimental pulmonary....pdf.jpgGenerated Thumbnailimage/jpeg1481https://www.arca.fiocruz.br/bitstream/icict/5744/4/Vidal%20MRFS%20Experimental%20pulmonary....pdf.jpg3614af49162c5143d135c603c10ec621MD54icict/57442023-03-15 14:33:14.592oai:www.arca.fiocruz.br:icict/5744TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
title Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
spellingShingle Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
Vidal, Maura R. F. S
Experimental schistosomiasis
Pulmonary schistosomiasis
Periovular granuloma
Immunological modulation
Granuloma/patologia
Pneumopatias Parasitárias/patologia
Esquistossomose/patologia
Animais
Granuloma/parasitologia
Pulmão/parasitologia
Pulmão/ultraestrutura
Masculino
Camundongos
Óvulo/parasitologia
Veia Porta/cirurgia
Fatores de Tempo
title_short Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
title_full Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
title_fullStr Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
title_full_unstemmed Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
title_sort Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
author Vidal, Maura R. F. S
author_facet Vidal, Maura R. F. S
Barbosa Junior, Aryon de Almeida
Andrade, Zilton de Araújo
author_role author
author2 Barbosa Junior, Aryon de Almeida
Andrade, Zilton de Araújo
author2_role author
author
dc.contributor.author.fl_str_mv Vidal, Maura R. F. S
Barbosa Junior, Aryon de Almeida
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Experimental schistosomiasis
Pulmonary schistosomiasis
Periovular granuloma
Immunological modulation
topic Experimental schistosomiasis
Pulmonary schistosomiasis
Periovular granuloma
Immunological modulation
Granuloma/patologia
Pneumopatias Parasitárias/patologia
Esquistossomose/patologia
Animais
Granuloma/parasitologia
Pulmão/parasitologia
Pulmão/ultraestrutura
Masculino
Camundongos
Óvulo/parasitologia
Veia Porta/cirurgia
Fatores de Tempo
dc.subject.decs.pt_BR.fl_str_mv Granuloma/patologia
Pneumopatias Parasitárias/patologia
Esquistossomose/patologia
Animais
Granuloma/parasitologia
Pulmão/parasitologia
Pulmão/ultraestrutura
Masculino
Camundongos
Óvulo/parasitologia
Veia Porta/cirurgia
Fatores de Tempo
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1993
dc.date.issued.fl_str_mv 1993
dc.date.accessioned.fl_str_mv 2012-10-30T20:32:24Z
dc.date.available.fl_str_mv 2012-10-30T20:32:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VIDAL, M. R. S.; BARBOSA JÚNIOR, A. A.; ANDRADE, Z. A. Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas. Revista do Instituto de Medicina Tropical de São Paulo, v. 35, n. 5, p. 423-9, sep.-oct. 1993.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5744
dc.identifier.issn.none.fl_str_mv 0036-4665
identifier_str_mv VIDAL, M. R. S.; BARBOSA JÚNIOR, A. A.; ANDRADE, Z. A. Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas. Revista do Instituto de Medicina Tropical de São Paulo, v. 35, n. 5, p. 423-9, sep.-oct. 1993.
0036-4665
url https://www.arca.fiocruz.br/handle/icict/5744
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