Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis

Detalhes bibliográficos
Autor(a) principal: Costa, Diego Luis
Data de Publicação: 2015
Outros Autores: Cardoso, Thiago Marconi de Souza, Queiroz, Adriano, Milanezi, Cristiane Maria, Bacellar, Maria Olívia Amado Ramos, Carvalho Filho, Edgar Marcelino, Silva, João Santana da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25061
Resumo: Carvalho Filho, Edgar Marcelino. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Costa, Diego LuisCardoso, Thiago Marconi de SouzaQueiroz, AdrianoMilanezi, Cristiane MariaBacellar, Maria Olívia Amado RamosCarvalho Filho, Edgar MarcelinoSilva, João Santana da2018-03-05T18:07:33Z2018-03-05T18:07:33Z2015COSTA, D. L. et al. Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis. The Journal of Infectious Diseases, v. 211, p. 708–718, 2015.0022-1899https://www.arca.fiocruz.br/handle/icict/2506110.1093/infdis/jiu406Carvalho Filho, Edgar Marcelino. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institutes of Health (grant AI30639-020) and the Fundação de Apoio à Pesquisa do Estado de São Paulo (grants 2008/05982-8 and 2007/53940-0).University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, BrazilFederal University of Bahia. University Hospital Professor Edgar Santos. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology in Tropical Diseases. Salvador, BA, BrasilFederal University of Bahia. University Hospital Professor Edgar Santos. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology in Tropical Diseases. Salvador, BA, BrasilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, BrazilFederal University of Bahia. University Hospital Professor Edgar Santos. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology in Tropical Diseases. Salvador, BA, BrasilFederal University of Bahia. University Hospital Professor Edgar Santos. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology in Tropical Diseases. Salvador, BA, BrasilUniversity of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, BrazilCD4(+)CD25(+)FOXP3(+) regulatory T cells have long been shown to mediate susceptibility to Leishmania infection, mainly via interleukin 10 production. In this work, we showed that the main sources of interleukin 10 in peripheral blood mononuclear cells (PBMCs) from patients with cutaneous leishmaniasis due to Leishmania braziliensis are CD4(+)CD25(-)CD127(-/low)FOXP3(-) cells. Compared with uninfected controls, patients with CL had increased frequencies of circulating interleukin 10-producing CD4(+)CD25(-)CD127(-/low) cells, which efficiently suppressed tumor necrosis factor α production by the total PBMC population. Also, in CL lesions, interleukin 10 was mainly produced by CD4(+)CD25(-) cells, and interleukin 10 messenger RNA expression was associated with interleukin 27, interleukin 21, and interferon γ expression, rather than with FOXP3 or transforming growth factor β expressions. Active production of both interleukin 27 and interleukin 21, together with production of interferon γ and interleukin 10, was also detected in the lesions. Since these cytokines are associated with the differentiation and activity of Tr-1 cells, our results suggest that this cell population may play an important role in the immunomodulation of CL. Therefore, development of treatments that interfere with this pathway may lead to faster parasite elimination.engOxford University PressL. braziliensisleishmaniose tegumentarCélulas Tr-1IL-10L. braziliensisTegumentary leishmaniasisTr-1 cellsIL-10Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25061/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta DL Tr-1-Like CD4+CD25-CD127-lowFOXP3....pdfCosta DL Tr-1-Like 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dc.title.pt_BR.fl_str_mv Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
title Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
spellingShingle Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
Costa, Diego Luis
L. braziliensis
leishmaniose tegumentar
Células Tr-1
IL-10
L. braziliensis
Tegumentary leishmaniasis
Tr-1 cells
IL-10
title_short Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
title_full Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
title_fullStr Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
title_full_unstemmed Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
title_sort Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis
author Costa, Diego Luis
author_facet Costa, Diego Luis
Cardoso, Thiago Marconi de Souza
Queiroz, Adriano
Milanezi, Cristiane Maria
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino
Silva, João Santana da
author_role author
author2 Cardoso, Thiago Marconi de Souza
Queiroz, Adriano
Milanezi, Cristiane Maria
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino
Silva, João Santana da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Diego Luis
Cardoso, Thiago Marconi de Souza
Queiroz, Adriano
Milanezi, Cristiane Maria
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino
Silva, João Santana da
dc.subject.other.pt_BR.fl_str_mv L. braziliensis
leishmaniose tegumentar
Células Tr-1
IL-10
topic L. braziliensis
leishmaniose tegumentar
Células Tr-1
IL-10
L. braziliensis
Tegumentary leishmaniasis
Tr-1 cells
IL-10
dc.subject.en.pt_BR.fl_str_mv L. braziliensis
Tegumentary leishmaniasis
Tr-1 cells
IL-10
description Carvalho Filho, Edgar Marcelino. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-03-05T18:07:33Z
dc.date.available.fl_str_mv 2018-03-05T18:07:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, D. L. et al. Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis. The Journal of Infectious Diseases, v. 211, p. 708–718, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25061
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jiu406
identifier_str_mv COSTA, D. L. et al. Tr-1-like CD4+CD25-CD127-/lowFOXP3- cells are the main source of interleukin 10 in patients with cutaneous leishmaniasis due to Leishmania braziliensis. The Journal of Infectious Diseases, v. 211, p. 708–718, 2015.
0022-1899
10.1093/infdis/jiu406
url https://www.arca.fiocruz.br/handle/icict/25061
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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