Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction

Detalhes bibliográficos
Autor(a) principal: Soares, Márcio
Data de Publicação: 2006
Outros Autores: Salluh, Jorge I. F., Carvalho, Marilia S., Darmon, Michael, Rocco, José R., Spector, Nelson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57416
Resumo: Instituto Nacional de Câncer. Intensive Care Unit. Rio de Janeiro, RJ, Brasil.
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spelling Soares, MárcioSalluh, Jorge I. F.Carvalho, Marilia S.Darmon, MichaelRocco, José R.Spector, Nelson2023-03-16T23:44:24Z2023-03-16T23:44:24Z2006SOARES, Márcio et al. Prognosis of Critically Ill Patients With Cancer and Acute Renal Dysfunction. Journal of Clinical Oncology, v. 24, n. 24. p. 4003-4010, 2006.0732-183Xhttps://www.arca.fiocruz.br/handle/icict/5741610.1200/JCO.2006.05.78691527-7755engAmerican Society of Clinical OncologyPrognosis of critically ill patients with Cancer and Acute Renal Dysfunctioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Câncer. Intensive Care Unit. Rio de Janeiro, RJ, Brasil.Hospital Barra D’Or. Intensive Care Unit. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Saint Louis University Hospital. Medical Intensive Care Unit. United States / Paris 7 University. France.Hôpitaux de Paris. Assistance Publique. Paris, France.Purpose: To evaluate the outcomes of critically ill patients with cancer and acute renal dysfunction. Patients and Methods: Prospective cohort study conducted at a 10-bed oncologic medical-surgical intensive care unit (ICU) over a 56-month period. Results: Of 975 patients, 309 (32%) had renal dysfunction and were studied. Their mean age was 60.9 ± 15.9 years; 233 patients (75%) had solid tumors and 76 (25%) had hematologic malignancies. During the ICU stay, 98 patients (32%) received dialysis. Renal dysfunction was multifactorial in 56% of the patients, and the main associated factors were shock/ischemia (72%) and sepsis (63%). Overall hospital and 6-month mortality rates were 64% and 73%, respectively. Among patients who required dialysis, mortality rates were lower in patients who received dialysis on the first day of ICU in comparison with those who required it thereafter. In a multivariable Cox model, age more than 60 years, uncontrolled cancer, impaired performance status, and more than two associated organ failures were associated with increased 6-month mortality. Renal function was completely re-established in 82% and partially re-established in 12%, and only 6% of survivors required chronic dialysis. Conclusion: Acute renal dysfunction is frequent in critically ill patients with cancer. Although mortality rates are high, selected patients can benefit from ICU care and advanced organ support. When evaluating prognosis and the appropriateness of dialysis in these patients, older age, functional capacity, cancer status and the severity of associated organ failures are important variables to take into consideration.CancerAcute Renal DysfunctionPrognosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57416/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALPrognosis.pdfapplication/pdf288039https://www.arca.fiocruz.br/bitstream/icict/57416/2/Prognosis.pdfcb9d174c9bccb9473485c2c7e0ed6ffaMD52icict/574162023-03-16 21:36:14.545oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-17T00:36:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
title Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
spellingShingle Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
Soares, Márcio
Cancer
Acute Renal Dysfunction
Prognosis
title_short Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
title_full Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
title_fullStr Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
title_full_unstemmed Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
title_sort Prognosis of critically ill patients with Cancer and Acute Renal Dysfunction
author Soares, Márcio
author_facet Soares, Márcio
Salluh, Jorge I. F.
Carvalho, Marilia S.
Darmon, Michael
Rocco, José R.
Spector, Nelson
author_role author
author2 Salluh, Jorge I. F.
Carvalho, Marilia S.
Darmon, Michael
Rocco, José R.
Spector, Nelson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Márcio
Salluh, Jorge I. F.
Carvalho, Marilia S.
Darmon, Michael
Rocco, José R.
Spector, Nelson
dc.subject.en.en_US.fl_str_mv Cancer
Acute Renal Dysfunction
Prognosis
topic Cancer
Acute Renal Dysfunction
Prognosis
description Instituto Nacional de Câncer. Intensive Care Unit. Rio de Janeiro, RJ, Brasil.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2023-03-16T23:44:24Z
dc.date.available.fl_str_mv 2023-03-16T23:44:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Márcio et al. Prognosis of Critically Ill Patients With Cancer and Acute Renal Dysfunction. Journal of Clinical Oncology, v. 24, n. 24. p. 4003-4010, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57416
dc.identifier.issn.en_US.fl_str_mv 0732-183X
dc.identifier.doi.none.fl_str_mv 10.1200/JCO.2006.05.7869
dc.identifier.eissn.none.fl_str_mv 1527-7755
identifier_str_mv SOARES, Márcio et al. Prognosis of Critically Ill Patients With Cancer and Acute Renal Dysfunction. Journal of Clinical Oncology, v. 24, n. 24. p. 4003-4010, 2006.
0732-183X
10.1200/JCO.2006.05.7869
1527-7755
url https://www.arca.fiocruz.br/handle/icict/57416
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Clinical Oncology
publisher.none.fl_str_mv American Society of Clinical Oncology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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https://www.arca.fiocruz.br/bitstream/icict/57416/2/Prognosis.pdf
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