Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology

Detalhes bibliográficos
Autor(a) principal: Novais, Fernanda Oliveira
Data de Publicação: 2015
Outros Autores: Carvalho, Lucas Pedreira de, Passos, Sara Timoteo, Roos, David S, Carvalho Filho, Edgar Marcelino, Scott, Phillip, Beiting, Daniel P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25495
Resumo: Carvalho Filho, Edgar Marcelino de; Carvalho, Lucas Pedreira de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
id CRUZ_a4b48c125ce7819d527e90b4c6c6891e
oai_identifier_str oai:www.arca.fiocruz.br:icict/25495
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Novais, Fernanda OliveiraCarvalho, Lucas Pedreira dePassos, Sara TimoteoRoos, David SCarvalho Filho, Edgar MarcelinoScott, PhillipBeiting, Daniel P2018-03-26T17:18:11Z2018-03-26T17:18:11Z2015Genomic profiling of humanNOVAIS, F. O. et al. Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology. Journal of Investigative Dermatology, v. 135, n. 1, p. 94–101, 2015.0022-202Xhttps://www.arca.fiocruz.br/handle/icict/2549510.1038/jid.2014.305Carvalho Filho, Edgar Marcelino de; Carvalho, Lucas Pedreira de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institutes of Health International Centers for Infectious Disease Research (U01-AUI 088650).University of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversity of Pennsylvania. Department of Biology. Philadelphia, PAUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversity of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAUniversity of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAThe host immune response has a critical role not only in protection from human leishmaniasis but also in promoting disease severity. Although candidate gene approaches in mouse models of leishmaniasis have been extremely informative, a global understanding of the immune pathways active in lesions from human patients is lacking. To address this issue, genome-wide transcriptional profiling of Leishmania braziliensis-infected cutaneous lesions and normal skin controls was carried out. A signature of the L. braziliensis skin lesion was defined, which includes over 2,000 differentially regulated genes. Pathway-level analysis of this transcriptional response revealed key biological pathways present in cutaneous lesions, generating a testable 'metapathway' model of immunopathology and providing new insights for treatment of human leishmaniasis.engNature Publishing GroupLeishmania braziliensisGenômicaPeleÚlcera da peleHumanosLeishmanioseLeishmania braziliensisGenomicsSkinSkin UlcerHumansLeishmaniasisGenomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25495/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNovais FO Genomic Profiling of Human Leishmania....pdfNovais FO Genomic Profiling of Human Leishmania....pdfapplication/pdf1021579https://www.arca.fiocruz.br/bitstream/icict/25495/2/Novais%20FO%20Genomic%20Profiling%20of%20Human%20Leishmania....pdf1f5614564be7b290c7ceaa513f731428MD52TEXTNovais FO Genomic Profiling of Human Leishmania....pdf.txtNovais FO Genomic Profiling of Human Leishmania....pdf.txtExtracted texttext/plain40894https://www.arca.fiocruz.br/bitstream/icict/25495/3/Novais%20FO%20Genomic%20Profiling%20of%20Human%20Leishmania....pdf.txt71960e7db5a4284ed8927bb9b6e06e78MD53icict/254952023-03-15 14:34:10.733oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
title Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
spellingShingle Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
Novais, Fernanda Oliveira
Leishmania braziliensis
Genômica
Pele
Úlcera da pele
Humanos
Leishmaniose
Leishmania braziliensis
Genomics
Skin
Skin Ulcer
Humans
Leishmaniasis
title_short Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
title_full Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
title_fullStr Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
title_full_unstemmed Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
title_sort Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
author Novais, Fernanda Oliveira
author_facet Novais, Fernanda Oliveira
Carvalho, Lucas Pedreira de
Passos, Sara Timoteo
Roos, David S
Carvalho Filho, Edgar Marcelino
Scott, Phillip
Beiting, Daniel P
author_role author
author2 Carvalho, Lucas Pedreira de
Passos, Sara Timoteo
Roos, David S
Carvalho Filho, Edgar Marcelino
Scott, Phillip
Beiting, Daniel P
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Novais, Fernanda Oliveira
Carvalho, Lucas Pedreira de
Passos, Sara Timoteo
Roos, David S
Carvalho Filho, Edgar Marcelino
Scott, Phillip
Beiting, Daniel P
dc.subject.other.pt_BR.fl_str_mv Leishmania braziliensis
Genômica
Pele
Úlcera da pele
Humanos
Leishmaniose
topic Leishmania braziliensis
Genômica
Pele
Úlcera da pele
Humanos
Leishmaniose
Leishmania braziliensis
Genomics
Skin
Skin Ulcer
Humans
Leishmaniasis
dc.subject.en.pt_BR.fl_str_mv Leishmania braziliensis
Genomics
Skin
Skin Ulcer
Humans
Leishmaniasis
description Carvalho Filho, Edgar Marcelino de; Carvalho, Lucas Pedreira de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-03-26T17:18:11Z
dc.date.available.fl_str_mv 2018-03-26T17:18:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Genomic profiling of humanNOVAIS, F. O. et al. Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology. Journal of Investigative Dermatology, v. 135, n. 1, p. 94–101, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25495
dc.identifier.issn.pt_BR.fl_str_mv 0022-202X
dc.identifier.doi.none.fl_str_mv 10.1038/jid.2014.305
identifier_str_mv Genomic profiling of humanNOVAIS, F. O. et al. Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology. Journal of Investigative Dermatology, v. 135, n. 1, p. 94–101, 2015.
0022-202X
10.1038/jid.2014.305
url https://www.arca.fiocruz.br/handle/icict/25495
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/25495/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/25495/2/Novais%20FO%20Genomic%20Profiling%20of%20Human%20Leishmania....pdf
https://www.arca.fiocruz.br/bitstream/icict/25495/3/Novais%20FO%20Genomic%20Profiling%20of%20Human%20Leishmania....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
1f5614564be7b290c7ceaa513f731428
71960e7db5a4284ed8927bb9b6e06e78
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009143714283520

Registros relacionados