Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26392 |
Resumo: | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
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Nunes, SaraSilva, Icaro BonyekAmpuero, Mariana RosaNoronha, Almério Libório Lopes deSouza, Lígia Correia Lima deCorreia, Thaizza CavalcanteCunha, Antonio Ricardo KhouriBoaventura, Viviane SampaioBarral, Aldina Maria PradoRamos, Pablo Ivan PereiraBrodskyn, Claudia IdaOliveira, Pablo Rafael SilveiraTavares, Natalia Machado2018-05-10T16:49:33Z2018-05-10T16:49:33Z2018NUNES, S. et al. Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Frontiers in Immunology, v. 9, abr. 2018.1664-3224https://www.arca.fiocruz.br/handle/icict/2639210.3389/fimmu.2018.00640engFrontiers MediaLeishmania braziliensismicroRNAPeleTranscriptomaTREM-1Leishmaniose humanaLeishmania braziliensismicroRNASkinTranscriptomeTREM-1Human leishmaniasisIntegrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilLaboratório de Anatomia Patológica. Feira de Santana, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centre for Data and Knowledge Integration for Health. Salvador, Ba, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centre for Data and Knowledge Integration for Health. Salvador, Ba, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilLocalized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and can be implicated in the pathogenesis of LCL. We investigated the involvement of miRNAs and their targets genes in human LCL using publicly available transcriptome data sets followed by ex vivo validation. Initial analysis highlighted that miRNA expression is altered during LCL, as patients clustered separately from controls. Joint analysis identified eight high confidence miRNAs that had altered expression (-1.5 ≤ fold change ≥ 1.5; p < 0.05) between cutaneous ulcers and uninfected skin. We found that the expression of miR-193b and miR-671 are greatly associated with their target genes, CD40 and TNFR, indicating the important role of these miRNAs in the expression of genes related to the inflammatory response observed in LCL. In addition, network analysis revealed that miR-193b, miR-671, and TREM1 correlate only in patients who show faster wound healing (up to 59 days) and not in patients who require longer cure times (more than 60 days). Given that these miRNAs are associated with control of inflammation and healing time, our findings reveal that they might influence the pathogenesis and prognosis of LCL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26392/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNunes S Integrated Analysis Reveals That miR-193b....pdfNunes S Integrated Analysis Reveals That miR-193b....pdfapplication/pdf4103629https://www.arca.fiocruz.br/bitstream/icict/26392/2/Nunes%20S%20Integrated%20Analysis%20Reveals%20That%20miR-193b....pdf8447bfa7915208ba900d14c3effa54e5MD52TEXTNunes S Integrated Analysis Reveals That miR-193b....pdf.txtNunes S Integrated Analysis Reveals That miR-193b....pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| title |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| spellingShingle |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis Nunes, Sara Leishmania braziliensis microRNA Pele Transcriptoma TREM-1 Leishmaniose humana Leishmania braziliensis microRNA Skin Transcriptome TREM-1 Human leishmaniasis |
| title_short |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| title_full |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| title_fullStr |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| title_full_unstemmed |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| title_sort |
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis |
| author |
Nunes, Sara |
| author_facet |
Nunes, Sara Silva, Icaro Bonyek Ampuero, Mariana Rosa Noronha, Almério Libório Lopes de Souza, Lígia Correia Lima de Correia, Thaizza Cavalcante Cunha, Antonio Ricardo Khouri Boaventura, Viviane Sampaio Barral, Aldina Maria Prado Ramos, Pablo Ivan Pereira Brodskyn, Claudia Ida Oliveira, Pablo Rafael Silveira Tavares, Natalia Machado |
| author_role |
author |
| author2 |
Silva, Icaro Bonyek Ampuero, Mariana Rosa Noronha, Almério Libório Lopes de Souza, Lígia Correia Lima de Correia, Thaizza Cavalcante Cunha, Antonio Ricardo Khouri Boaventura, Viviane Sampaio Barral, Aldina Maria Prado Ramos, Pablo Ivan Pereira Brodskyn, Claudia Ida Oliveira, Pablo Rafael Silveira Tavares, Natalia Machado |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nunes, Sara Silva, Icaro Bonyek Ampuero, Mariana Rosa Noronha, Almério Libório Lopes de Souza, Lígia Correia Lima de Correia, Thaizza Cavalcante Cunha, Antonio Ricardo Khouri Boaventura, Viviane Sampaio Barral, Aldina Maria Prado Ramos, Pablo Ivan Pereira Brodskyn, Claudia Ida Oliveira, Pablo Rafael Silveira Tavares, Natalia Machado |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania braziliensis microRNA Pele Transcriptoma TREM-1 Leishmaniose humana |
| topic |
Leishmania braziliensis microRNA Pele Transcriptoma TREM-1 Leishmaniose humana Leishmania braziliensis microRNA Skin Transcriptome TREM-1 Human leishmaniasis |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania braziliensis microRNA Skin Transcriptome TREM-1 Human leishmaniasis |
| description |
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
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2018 |
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2018-05-10T16:49:33Z |
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2018-05-10T16:49:33Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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NUNES, S. et al. Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Frontiers in Immunology, v. 9, abr. 2018. |
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https://www.arca.fiocruz.br/handle/icict/26392 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2018.00640 |
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NUNES, S. et al. Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Frontiers in Immunology, v. 9, abr. 2018. 1664-3224 10.3389/fimmu.2018.00640 |
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