Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study

Detalhes bibliográficos
Autor(a) principal: Araujo, Nelia Cláudia Neri
Data de Publicação: 2020
Outros Autores: Cruz, Constança Margarida Sampaio, Arriaga Gutiérrez, María Belen, Cubillos-Angulo, Juan Manuel, Rocha, Michael Santos, Mattos, Paulo Sérgio de Morais da Silveira, Matos, Gisela M., Marques, Izabella M. B., Espírito Santo, Isa Carolina Paim do, Almeida, Luiza L., Andrade, Caroline M., Souza, Leonardo A., Martins Netto, Eduardo, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40672
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). The funders had no role in study design, data extraction and analysis, the decision to publish, or the preparation of the manuscript.
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spelling Araujo, Nelia Cláudia NeriCruz, Constança Margarida SampaioArriaga Gutiérrez, María BelenCubillos-Angulo, Juan ManuelRocha, Michael SantosMattos, Paulo Sérgio de Morais da SilveiraMatos, Gisela M.Marques, Izabella M. B.Espírito Santo, Isa Carolina Paim doAlmeida, Luiza L.Andrade, Caroline M.Souza, Leonardo A.Martins Netto, EduardoAndrade, Bruno de Bezerril2020-04-07T18:03:57Z2020-04-07T18:03:57Z2020ARAUJO, Nelia Cláudia Neri et al. Determinants losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, p. 1-23, Feb. 2020.1201-9712https://www.arca.fiocruz.br/handle/icict/4067210.1016/j.ijid.2020.02.015Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). The funders had no role in study design, data extraction and analysis, the decision to publish, or the preparation of the manuscript.Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Obras Sociais Irmã Dulce. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil.The present study evaluated factors associated with losses in the latent tuberculosis infection (LTBI) cascade of care in contacts of tuberculosis (TB) patients, in a referral center from a highly endemic region in Brazil. Methods: Contacts of 1,672 TB patients were retrospectively studied between 2009 and 2014. Data on TB screening by clinical investigation, radiographic examination and tuberculin skin test (TST) were extracted from medical records. Losses in the cascade of care and TB incidence within 2-year follow-up were calculated. Results: From a total of 1,180 TB contacts initially identified, only 495 were examined (58% loss), and 20 were diagnosed with active TB at this stage. Furthermore, 435 persons returned for TST result interpretation and 351 (~81%) were TST positive. Among those with positive TST, 249 (73%) were treated with isoniazid for 6 months whereas 51 abandoned therapy early. Three individuals who did not receive LTBI treatment, one with incomplete treatment and another who completed treatment developed active TB. A logistic regression analysis revealed that increases in age were associated with losses in the LTBI cascade independent of other clinical and epidemiological characteristics. Conclusions: Major losses occur at initial stages and older patients are at higher risk of not completing the LTBI cascade of care.engElsevierTuberculoseInfecção latente por TBCscata LTBITratamento para TB latenteTuberculosisLatent TB infectionLTBI cascadeTreatment for latent TBDeterminants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40672/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAraujo, N.C.N. Determinants....pdfAraujo, N.C.N. Determinants....pdfapplication/pdf1976039https://www.arca.fiocruz.br/bitstream/icict/40672/2/Araujo%2c%20N.C.N.%20Determinants....pdfddf32d2f5cd1578d464d7953f3f141d4MD52TEXTAraujo, N.C.N. 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dc.title.pt_BR.fl_str_mv Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
title Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
spellingShingle Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
Araujo, Nelia Cláudia Neri
Tuberculose
Infecção latente por TB
Cscata LTBI
Tratamento para TB latente
Tuberculosis
Latent TB infection
LTBI cascade
Treatment for latent TB
title_short Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
title_full Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
title_fullStr Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
title_full_unstemmed Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
title_sort Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study
author Araujo, Nelia Cláudia Neri
author_facet Araujo, Nelia Cláudia Neri
Cruz, Constança Margarida Sampaio
Arriaga Gutiérrez, María Belen
Cubillos-Angulo, Juan Manuel
Rocha, Michael Santos
Mattos, Paulo Sérgio de Morais da Silveira
Matos, Gisela M.
Marques, Izabella M. B.
Espírito Santo, Isa Carolina Paim do
Almeida, Luiza L.
Andrade, Caroline M.
Souza, Leonardo A.
Martins Netto, Eduardo
Andrade, Bruno de Bezerril
author_role author
author2 Cruz, Constança Margarida Sampaio
Arriaga Gutiérrez, María Belen
Cubillos-Angulo, Juan Manuel
Rocha, Michael Santos
Mattos, Paulo Sérgio de Morais da Silveira
Matos, Gisela M.
Marques, Izabella M. B.
Espírito Santo, Isa Carolina Paim do
Almeida, Luiza L.
Andrade, Caroline M.
Souza, Leonardo A.
Martins Netto, Eduardo
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Nelia Cláudia Neri
Cruz, Constança Margarida Sampaio
Arriaga Gutiérrez, María Belen
Cubillos-Angulo, Juan Manuel
Rocha, Michael Santos
Mattos, Paulo Sérgio de Morais da Silveira
Matos, Gisela M.
Marques, Izabella M. B.
Espírito Santo, Isa Carolina Paim do
Almeida, Luiza L.
Andrade, Caroline M.
Souza, Leonardo A.
Martins Netto, Eduardo
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Tuberculose
Infecção latente por TB
Cscata LTBI
Tratamento para TB latente
topic Tuberculose
Infecção latente por TB
Cscata LTBI
Tratamento para TB latente
Tuberculosis
Latent TB infection
LTBI cascade
Treatment for latent TB
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Latent TB infection
LTBI cascade
Treatment for latent TB
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). The funders had no role in study design, data extraction and analysis, the decision to publish, or the preparation of the manuscript.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-04-07T18:03:57Z
dc.date.available.fl_str_mv 2020-04-07T18:03:57Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, Nelia Cláudia Neri et al. Determinants losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, p. 1-23, Feb. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40672
dc.identifier.issn.pt_BR.fl_str_mv 1201-9712
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.ijid.2020.02.015
identifier_str_mv ARAUJO, Nelia Cláudia Neri et al. Determinants losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, p. 1-23, Feb. 2020.
1201-9712
10.1016/j.ijid.2020.02.015
url https://www.arca.fiocruz.br/handle/icict/40672
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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