Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18446 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Gandini, MarianaReis, Sonia Regina Nogueira IgnacioCarvalho, Amanda TorrentesAzeredo, Elzinandes lealFreire, Marcos da SilvaGaller, RicardoKubelka, Claire Fernandes2017-04-15T13:59:26Z2017-04-15T13:59:26Z2011GANDINI, Mariana; et al. Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles. Mem Inst Oswaldo Cruz, v.106, n.5, p.594-605, Aug. 2011.1678-8080https://www.arca.fiocruz.br/handle/icict/18446engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.CitocinasVírus da dengueVacina da febre amarelaFlavivírusCélulas dendríticasFlaviviruscyrokinesdendritic cellsdengue virusyellow fever vaccineflavivirusDengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profilesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos.Departamento de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos.Departamento de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Flaviviruses cause severe acute febrile and haemorrhagic infections, including dengue and yellow fever and the pathogenesis of these infections is caused by an exacerbated immune response. Dendritic cells (DCs) are targets for dengue virus (DENV) and yellow fever virus (YF) replication and are the first cell population to interact with these viruses during a natural infection, which leads to an induction of protective immunity in humans. We studied the infectivity of DENV2 (strain 16681), a YF vaccine (YF17DD) and a chimeric YF17D/DENV2 vaccine in monocytederived DCs in vitro with regard to cell maturation, activation and cytokine production. Higher viral antigen positive cell frequencies were observed for DENV2 when compared with both vaccine viruses. Flavivirus-infected cultures exhibited dendritic cell activation and maturation molecules. CD38 expression on DCs was enhanced for both DENV2 and YF17DD, whereas OX40L expression was decreased as compared to mock-stimulated cells, suggesting that a T helper 1 profile is favoured. Tumor necrosis factor (TNF)-α production in cell cultures was significantly higher in DENV2-infected cultures than in cultures infected with YF17DD or YF17D/DENV. In contrast, the vaccines induced higher IFN-α levels than DENV2. The differential cytokine production indicates that DENV2 results in TNF induction, which discriminates it from vaccine viruses that preferentially stimulate interferon expression. These differential response profiles may influence the pathogenic infection outcomeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18446/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmariana2_gandini_etal_2011.pdfmariana2_gandini_etal_2011.pdfapplication/pdf1096001https://www.arca.fiocruz.br/bitstream/icict/18446/2/mariana2_gandini_etal_2011.pdfcf2b4f5e4aff659654ed08cd217a2601MD52TEXTmariana2_gandini_etal_2011.pdf.txtmariana2_gandini_etal_2011.pdf.txtExtracted texttext/plain62773https://www.arca.fiocruz.br/bitstream/icict/18446/3/mariana2_gandini_etal_2011.pdf.txtd32a6b280ee85b4827848490f425ab3fMD53icict/184462018-08-15 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| dc.title.pt_BR.fl_str_mv |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| title |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| spellingShingle |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles Gandini, Mariana Citocinas Vírus da dengue Vacina da febre amarela Flavivírus Células dendríticas Flavivirus cyrokines dendritic cells dengue virus yellow fever vaccine flavivirus |
| title_short |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| title_full |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| title_fullStr |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| title_full_unstemmed |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| title_sort |
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles |
| author |
Gandini, Mariana |
| author_facet |
Gandini, Mariana Reis, Sonia Regina Nogueira Ignacio Carvalho, Amanda Torrentes Azeredo, Elzinandes leal Freire, Marcos da Silva Galler, Ricardo Kubelka, Claire Fernandes |
| author_role |
author |
| author2 |
Reis, Sonia Regina Nogueira Ignacio Carvalho, Amanda Torrentes Azeredo, Elzinandes leal Freire, Marcos da Silva Galler, Ricardo Kubelka, Claire Fernandes |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Gandini, Mariana Reis, Sonia Regina Nogueira Ignacio Carvalho, Amanda Torrentes Azeredo, Elzinandes leal Freire, Marcos da Silva Galler, Ricardo Kubelka, Claire Fernandes |
| dc.subject.other.pt_BR.fl_str_mv |
Citocinas Vírus da dengue Vacina da febre amarela Flavivírus Células dendríticas Flavivirus |
| topic |
Citocinas Vírus da dengue Vacina da febre amarela Flavivírus Células dendríticas Flavivirus cyrokines dendritic cells dengue virus yellow fever vaccine flavivirus |
| dc.subject.en.pt_BR.fl_str_mv |
cyrokines dendritic cells dengue virus yellow fever vaccine flavivirus |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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2011 |
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2011 |
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2017-04-15T13:59:26Z |
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2017-04-15T13:59:26Z |
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info:eu-repo/semantics/article |
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article |
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GANDINI, Mariana; et al. Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles. Mem Inst Oswaldo Cruz, v.106, n.5, p.594-605, Aug. 2011. |
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https://www.arca.fiocruz.br/handle/icict/18446 |
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1678-8080 |
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GANDINI, Mariana; et al. Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles. Mem Inst Oswaldo Cruz, v.106, n.5, p.594-605, Aug. 2011. 1678-8080 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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