Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide

Detalhes bibliográficos
Autor(a) principal: Fernandes, Tania Rita Moreno de Oliveira
Data de Publicação: 2014
Outros Autores: Santos, Itamar, Korinsfky, Juliana Pedrosa, Silva, Benedyto Sávio Lima e, Carvalho, Luis Otávio, Plaper, Hélio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10568
Resumo: Universidade Federal do Vale do São Francisco. Departamento de Medicina. Petrolina, PE, Brasil.
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spelling Fernandes, Tania Rita Moreno de OliveiraSantos, ItamarKorinsfky, Juliana PedrosaSilva, Benedyto Sávio Lima eCarvalho, Luis OtávioPlaper, Hélio2015-05-27T13:39:55Z2015-05-27T13:39:55Z2014FERNANDES, Tania Rita Moreno de Oliveira et al. Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide. Acta Cirúrgica Brasileira, v.29, n.1, p.7-17, 2014.1678-2674https://www.arca.fiocruz.br/handle/icict/10568engSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaCutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticideinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Vale do São Francisco. Departamento de Medicina. Petrolina, PE, Brasil.Universidade Federal do Vale do São Francisco. Departamento de Medicina. Petrolina, PE, Brasil.Universidade Federal do Vale do São Francisco. Departamento de Enfermagem. Petrolina, PE, Brasil.Universidade Federal do Vale do São Francisco. Departamento de Medicina. Petrolina, PE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Divisão de Histologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de São Paulo (UNIFESP). Escola Paulista de Medicina. Departamento de Cirurgia. São Paulo, SP, Brasil.ABSTRACTPURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher’s and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.EpidermisSolar radiationSkin NeoplasmsOrganophosphatesRatsOrganofosfatosNeoplasias CutâneasRadiação solarRatosEpidermeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10568/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALluis_carvalhoetal_IOC_2014.pdfapplication/pdf1070360https://www.arca.fiocruz.br/bitstream/icict/10568/2/luis_carvalhoetal_IOC_2014.pdff0f9be522a1ee361b4210cdf4fe0ee97MD52TEXTluis_carvalhoetal_IOC_2014.pdf.txtluis_carvalhoetal_IOC_2014.pdf.txtExtracted texttext/plain28831https://www.arca.fiocruz.br/bitstream/icict/10568/3/luis_carvalhoetal_IOC_2014.pdf.txtb4cb05ab7f968d869e1d7e8019b1cd19MD53icict/105682022-06-24 13:03:00.419oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
spellingShingle Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Fernandes, Tania Rita Moreno de Oliveira
Epidermis
Solar radiation
Skin Neoplasms
Organophosphates
Rats
Organofosfatos
Neoplasias Cutâneas
Radiação solar
Ratos
Epiderme
title_short Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_full Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_fullStr Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_full_unstemmed Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_sort Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
author Fernandes, Tania Rita Moreno de Oliveira
author_facet Fernandes, Tania Rita Moreno de Oliveira
Santos, Itamar
Korinsfky, Juliana Pedrosa
Silva, Benedyto Sávio Lima e
Carvalho, Luis Otávio
Plaper, Hélio
author_role author
author2 Santos, Itamar
Korinsfky, Juliana Pedrosa
Silva, Benedyto Sávio Lima e
Carvalho, Luis Otávio
Plaper, Hélio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Tania Rita Moreno de Oliveira
Santos, Itamar
Korinsfky, Juliana Pedrosa
Silva, Benedyto Sávio Lima e
Carvalho, Luis Otávio
Plaper, Hélio
dc.subject.en.pt_BR.fl_str_mv Epidermis
Solar radiation
Skin Neoplasms
Organophosphates
Rats
topic Epidermis
Solar radiation
Skin Neoplasms
Organophosphates
Rats
Organofosfatos
Neoplasias Cutâneas
Radiação solar
Ratos
Epiderme
dc.subject.decs.pt_BR.fl_str_mv Organofosfatos
Neoplasias Cutâneas
Radiação solar
Ratos
Epiderme
description Universidade Federal do Vale do São Francisco. Departamento de Medicina. Petrolina, PE, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-27T13:39:55Z
dc.date.available.fl_str_mv 2015-05-27T13:39:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, Tania Rita Moreno de Oliveira et al. Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide. Acta Cirúrgica Brasileira, v.29, n.1, p.7-17, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10568
dc.identifier.issn.pt_BR.fl_str_mv 1678-2674
identifier_str_mv FERNANDES, Tania Rita Moreno de Oliveira et al. Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide. Acta Cirúrgica Brasileira, v.29, n.1, p.7-17, 2014.
1678-2674
url https://www.arca.fiocruz.br/handle/icict/10568
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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