Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide

Detalhes bibliográficos
Autor(a) principal: Fernandes,Tania Rita Moreno de Oliveira
Data de Publicação: 2014
Outros Autores: Santos,Itamar, Korinsfky,Juliana Pedrosa, Silva,Benedyto Sávio Lima e, Carvalho,Luis Otávio, Plapler,Hélio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007
Resumo: PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.
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spelling Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticideEpidermisSolar RadiationSkin NeoplasmsOrganophosphatesRatsPURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007Acta Cirúrgica Brasileira v.29 n.1 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000100002info:eu-repo/semantics/openAccessFernandes,Tania Rita Moreno de OliveiraSantos,ItamarKorinsfky,Juliana PedrosaSilva,Benedyto Sávio Lima eCarvalho,Luis OtávioPlapler,Hélioeng2015-10-08T00:00:00Zoai:scielo:S0102-86502014000100007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
spellingShingle Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Fernandes,Tania Rita Moreno de Oliveira
Epidermis
Solar Radiation
Skin Neoplasms
Organophosphates
Rats
title_short Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_full Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_fullStr Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_full_unstemmed Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
title_sort Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
author Fernandes,Tania Rita Moreno de Oliveira
author_facet Fernandes,Tania Rita Moreno de Oliveira
Santos,Itamar
Korinsfky,Juliana Pedrosa
Silva,Benedyto Sávio Lima e
Carvalho,Luis Otávio
Plapler,Hélio
author_role author
author2 Santos,Itamar
Korinsfky,Juliana Pedrosa
Silva,Benedyto Sávio Lima e
Carvalho,Luis Otávio
Plapler,Hélio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes,Tania Rita Moreno de Oliveira
Santos,Itamar
Korinsfky,Juliana Pedrosa
Silva,Benedyto Sávio Lima e
Carvalho,Luis Otávio
Plapler,Hélio
dc.subject.por.fl_str_mv Epidermis
Solar Radiation
Skin Neoplasms
Organophosphates
Rats
topic Epidermis
Solar Radiation
Skin Neoplasms
Organophosphates
Rats
description PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502014000100002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.29 n.1 2014
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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