Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007 |
Resumo: | PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation. |
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Acta Cirúrgica Brasileira (Online) |
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Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticideEpidermisSolar RadiationSkin NeoplasmsOrganophosphatesRatsPURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007Acta Cirúrgica Brasileira v.29 n.1 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000100002info:eu-repo/semantics/openAccessFernandes,Tania Rita Moreno de OliveiraSantos,ItamarKorinsfky,Juliana PedrosaSilva,Benedyto Sávio Lima eCarvalho,Luis OtávioPlapler,Hélioeng2015-10-08T00:00:00Zoai:scielo:S0102-86502014000100007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
title |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
spellingShingle |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide Fernandes,Tania Rita Moreno de Oliveira Epidermis Solar Radiation Skin Neoplasms Organophosphates Rats |
title_short |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
title_full |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
title_fullStr |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
title_full_unstemmed |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
title_sort |
Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide |
author |
Fernandes,Tania Rita Moreno de Oliveira |
author_facet |
Fernandes,Tania Rita Moreno de Oliveira Santos,Itamar Korinsfky,Juliana Pedrosa Silva,Benedyto Sávio Lima e Carvalho,Luis Otávio Plapler,Hélio |
author_role |
author |
author2 |
Santos,Itamar Korinsfky,Juliana Pedrosa Silva,Benedyto Sávio Lima e Carvalho,Luis Otávio Plapler,Hélio |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes,Tania Rita Moreno de Oliveira Santos,Itamar Korinsfky,Juliana Pedrosa Silva,Benedyto Sávio Lima e Carvalho,Luis Otávio Plapler,Hélio |
dc.subject.por.fl_str_mv |
Epidermis Solar Radiation Skin Neoplasms Organophosphates Rats |
topic |
Epidermis Solar Radiation Skin Neoplasms Organophosphates Rats |
description |
PURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502014000100002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.29 n.1 2014 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442200629248 |